Capillary breakup in multimaterial fibers is explored for the self-assembly of optoelectronic systems. However, its insights primarily stem from numerical simulations, qualitative at best. The authors formulate an analytical model of such breakup, obtaining a window in the governing parameters where the generally chaotic breakup becomes predictable and thus engineerable.

Spin defects in semiconductors are promising for quantum technologies but understanding of defect formation processes in experiment remains incomplete. Here the authors present a computational protocol to study the formation of spin defects at the atomic scale and apply it to the divacancy defect in SiC.

Near-ambient superconductivity and pressure-driven color changes were recently reported in nitrogen-doped lutetium hydride. Here, the authors synthesize LuH_2±xN_y and do not confirm the superconductivity. In addition, they find that the color changes likely stem from pressure-induced electron redistribution of nitrogen and vacancies.

How matter deform is a central question in mechanics of materials science. Here, the authors reveal a size-dependent deformation in amorphous metals changing at ~100 nanometer sample size from collective homogeneous flow to interface diffusion realized through individual atomic transport.

Since the discovery of proton radioactivity in ^53mCo, there has been no direct measurement of its branching ratio. Here the authors report the first measurement of the weak proton decay in ^53mCo by combining results from advanced detection systems.

Dixit et al. trace emissions from the extraction and transport of oil. They quantify emissions variability among crude blends and suggest how this variability could be used to further reduce emissions under scenarios for reduced future oil demand.

Enzymatic degradation of pollutants under mild conditions is promising for efficient degradation of environmental contaminants under facile operation conditions, but natural enzymes tend to lose enzymatic activity in environmental application scenarios. Here, the authors report a metal-organic frameworks-based artificial enzyme system to achieve high hydrolytic activity under mild conditions.

This study indicates that allowing up to 20% abated fossil fuel in China’s power generation system could reduce the power shortage rate by up to 9% in 2050, and increase system resilience during weather events relative to a zero fossil fuel system.

Connecting river basins using canals and reservoirs can improve water security but can also perturb land-atmosphere feedbacks. This paper analyzes India’s river-interlinking projects and finds that such projects can affect the monsoon rainfall.

The Indian and East Asian summer monsoons are found to be synchronized at the subseasonal timescale via a Rossby wave triggered by the Indian summer monsoon heating. The impact on East Asian precipitation varies with the subtropical jet structure.

Here, the authors analysed immune response to two consecutive coronavirus infections and observed that hamsters infected with seasonal coronaviruses were not protected from COVID-19 despite cross-reactive antibodies. Antiviral and germinal center B cell responses were suppressed but not during SARS-CoV-2 variant infections.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

IFNγ signalling has been described as a potential driver of resistance to immune checkpoint blockade (ICB) therapy. Here the authors report that PARP14 is upregulated in chronic IFNγ-treated cancer cell models and that its inhibition restores response to anti-PD-1 therapy in preclinical cancer models.

Deep learning-based models for tracking behavior are often constrained by manual annotation. Here, authors present GlowTrack, an approach using fluorescence to generate large and diverse training sets that improve model robustness and tracking coverage.

The regulation and intracellular transport of Ca²⁺ in immune cells involves Ca²⁺ release-activated Ca²⁺ (CRAC) channels. Here the authors show targeting CRAC components Orai1 and Orai2 modulates pulmonary ILC2 cells altering their metabolism, function and is linked to alleviation of immunopathology in a murine model of allergic airway disease.

The regulation and intracellular transport of Ca²⁺ in immune cells involves Ca²⁺ release-activated Ca²⁺ (CRAC) channels. Here the authors show targeting CRAC components Orai1 and Orai2 modulates pulmonary ILC2 cells altering their metabolism, function and is linked to alleviation of immunopathology in a murine model of allergic airway disease.

Induction of hypothermia during hibernation/torpor enables certain mammals to survive under extreme conditions. Here, the authors show that the natural product P57 induces hypothermia by targeting pyridoxal kinase and has a potential application in therapeutic hypothermia.

IFNγ signalling has been described as a potential driver of resistance to immune checkpoint blockade (ICB) therapy. Here the authors report that PARP14 is upregulated in chronic IFNγ-treated cancer cell models and that its inhibition restores response to anti-PD-1 therapy in preclinical cancer models.

Deep learning-based models for tracking behavior are often constrained by manual annotation. Here, authors present GlowTrack, an approach using fluorescence to generate large and diverse training sets that improve model robustness and tracking coverage.

Here, the authors apply the Activity-by-Contact (ABC) model to infer enhancer-gene regulation and the effect of associated variants across multiple cancer types, integrating genetic and multi-omics data. Then, they explore the mechanisms associated with ABC regulatory variants in colorectal cancer.

Dixit et al. trace emissions from the extraction and transport of oil. They quantify emissions variability among crude blends and suggest how this variability could be used to further reduce emissions under scenarios for reduced future oil demand.

This study indicates that allowing up to 20% abated fossil fuel in China’s power generation system could reduce the power shortage rate by up to 9% in 2050, and increase system resilience during weather events relative to a zero fossil fuel system.

Temporal causation models perform poorly in causal inference for variables with limited temporal variations. This paper establishes a causal inference model, which can reveal the nonlinear complex casual associations based on cross-sectional Earth System data.

Here the authors find economic damage from El Niño far greater than benefits from La Niña on the global economy, leading to an increased economic loss as ENSO variability intensifies under greenhouse warming.

U.S. federal climate policies can reduce air pollutant emissions and associated health impacts from fine particulate matter. However, near-term CO₂ reductions alone are insufficient to address racial/ethnic disparities in pollution exposure.