Here the authors demonstate that counter to expectation provided by the relevant standard reduction potentials, a chloroberyllate, [{SiNDipp}BeClLi]2, reacts with the group 1 elements (M = Na, K, Rb, Cs) to provide the respective heavier alkali metal analogues, [{SiNDipp}BeClM]2.

Peptide drug manufacturing commonly uses large amounts of hazardous solvents primarily due to multiple washings after each step. Here, the authors introduce the concept of a completely wash-free methodology that enables up to 95% waste reduction.

Contrary to photocatalysis, the use of photochemical energy solely to initiate reactions is underexplored. Here, the authors demonstrate light initiated synthesis of functionalized organosilanols, silanediols, and polymeric siloxanol under ambient reaction conditions.

One-dimensional materials have interesting physiochemical properties, but control over porosity is still a significant challenge. Here, the authors report a self-assembly method for the fabrication of 1D materials with an ordered mesostructure.

While heat modification is ubiquitous in biologic systems, it remains a significant challenge in artificial systems. Here the authors demonstrate thermal regulation of conversion between different rigid macrocycle atropisomers and related self-assemblies.

PREMA, the highly fusible Prevalent Mantle now found throughout the mantle, may have been generated soon after Earth’s accretion with minimal subsequent modification, according to a combination of composition data from Cenozoic sodic basalts and mantle convection simulations

This study introduce the Global Biojet Fuel Sustainability Index, a holistic 25-indicator sustainability index encompassing the four domains of energy-water-food nexus and governance, to measure the potential impact of RJF productions on 154 countries/territories through the oil-to-jet, alcohol-to-jet and gas-to-jet conversion methods.

A static tilt of some 0.17° between the rotation axes of the solid inner core and the mantle is inferred from the observed approximate 8.5 year periodic inner core wobble in both polar motion and length-of-day variations of the Earth’s rotation.

The coal chemical sector uses coal to produce chemicals and emits substantial greenhouse gases, which are hard to abate by electrification alone. Deploying green H₂ for China’s coal chemical plants can reduce ~50% of emissions at a low cost.

Deciphering the relationship between prolonged topographic growth and temporary earthquake uplift is challenging due to the mismatch in their deformation patterns. Zhang et al. introduce a novel model to address this highly hotly-debated discrepancy.

Accurately benchmarking small variant calling accuracy is critical for the continued improvement of human genome sequencing. Here, the authors show that current approaches are biased towards certain variant representations and develop a new approach to ensure consistent and accurate benchmarking, regardless of the original variant representations.

The bark is the outermost defense of trees against microbial attack, largely due to toxicity of extractive compounds. Here, Ristinmaa et al. study microbial community dynamics and chemical changes during degradation of spruce bark over six months, showing that the microbial degradation of extractive compounds, such as resin acids, has a major role in shaping the microbial community.

Cells in the body live in geometrically constrained microenvironments. Here, Feng at al report that these constraints induce collagen IV expression which is responsible for location dependent bacterial adhesion.

Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) arises from mutations in Angiotensin II sensing genes, but how they impact the kidney was unclear. This study reveals that delayed angiogenesis at a critical developmental window underlies AR-RTD.

The cryo-EM structures of an FCP trimer and a PSII-FCPII supercomplex from a diatom are revealed, providing detailed insights into the variety of FCPII and their regulatory roles in green light harvesting, energy transfer and dissipation.

The mode of action of the tuberculosis antibiotic pyrazinamide is poorly understood. Here, Krug et al show that pyrazinamide inhibits the immune regulator PARP1 and demonstrate PARP1 inhibition as a host-directed therapy.

Polyunsaturated fatty acid-derived bioactive lipids play critical roles as signalling molecules in metabolic processes. Here, the author show 13-HODE produced by senescent hepatocytes and macrophages activates SREBP1 by directly inhibiting CAT activity and promotes age-related steatosis.

Accurate diagnosis of Alzheimer’s disease in its earliest stage can prevent the disease and delay the symptoms. Here the authors identify a potential Alzheimer’s biomarker from tear fluid, and develop a nanoparticle-based immunoassay for its detection, demonstrating potential in Alzheimer’s diagnosis.

Mammalian circadian clocks align with feeding and light cues. Here, the authors reveal a role for astrocytic insulin-dopaminergic signaling in sex-specific circadian behavior and energy balance regulation.

NEIL2, a mammalian DNA repair enzyme, has been reported to suppress infection induced inflammation. Here, the authors characterize its role in modulating the severity of SARS-CoV-2 infection.

Accurately benchmarking small variant calling accuracy is critical for the continued improvement of human genome sequencing. Here, the authors show that current approaches are biased towards certain variant representations and develop a new approach to ensure consistent and accurate benchmarking, regardless of the original variant representations.

This study introduce the Global Biojet Fuel Sustainability Index, a holistic 25-indicator sustainability index encompassing the four domains of energy-water-food nexus and governance, to measure the potential impact of RJF productions on 154 countries/territories through the oil-to-jet, alcohol-to-jet and gas-to-jet conversion methods.

The emissions pathways of most publicly traded companies in high-emitting sectors are not aligned with the climate targets of the Paris Agreement. An extensive analysis of companies’ sustainability behaviour offers insights into why this is the case.

Most inhabited areas in the US have more mass in buildings and mobility networks than in plant biomass. Cities are comparably resource efficient, while high material intensity is found in rural areas. Migration reinforces this phenomenon as people leave while built structures remain.

Risk of isolation is expected to disproportionately affect racial minority populations in the U.S. as sea level rise increases. Communities with more renters, older adults, and lower-income populations will also be impacted.