A person receiving sound therapy through headphones and electrical stimulation on their tongue

Combining sound with tongue stimulation for the treatment of tinnitus

Michael Boedts and colleagues report positive efficacy and safety results of a nonsurgical treatment for tinnitus, using a device that combines sound therapy with electrical tongue stimulation.

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  • European forest tree species experienced strong climatic fluctuations over Quaternary. In spite of these pronounced environmental changes, population genomic analyses reveal that major forest tree species managed to retain their evolutionary potential over the period.

    • Pascal Milesi
    • Chedly Kastally
    • Tanja Pyhäjärvi
    ArticleOpen Access
  • Low dose-radiation therapy (LDRT) can promote anti-tumor immune responses. Here the authors propose to combine the immunostimulatory properties of LDRT with the cell killing/shrinkage properties of high dose RT within the same tumor mass as a strategy to optimize RT-induced anti-tumor immune responses.

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    • Morgane Dos Santos
    • Michele Mondini
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  • Marine heatwaves can have severe impact on corals populations. This study demonstrates that selective breeding could quickly enhance coral tolerance to short-term heat stress by up to 1 °C. This has potential to mitigate some impacts of climate change, however urgent climate action is still needed.

    • Adriana Humanes
    • Liam Lachs
    • James R. Guest
    ArticleOpen Access

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  • Antimicrobial resistance is a One Health problem that impacts humans, animals, and the environment. In this Comment, the authors discuss evidence for antimicrobial resistance transmission to humans, highlighting contrasting pictures between high- and low/middle-income settings.

    • Patrick Musicha
    • Tracy Morse
    • Nicholas A. Feasey
    CommentOpen Access
  • The integrated and indivisible nature of the SDGs is facing implementation challenges due to the silo approaches. We present the three interconnected foci (SDG interactions, modeling, and tools) at the science-policy interface to address these challenges. Accounting for them will support accelerated SDG progress, operationalizing the integration and indivisibility principles.

    • Prajal Pradhan
    • Nina Weitz
    • Caroline Zimm
    CommentOpen Access
  • As multiple UN fora develop parallel rules for sharing benefits from digital sequence information, we urge better coordination. International policymakers should focus on harmonizing new benefit-sharing rules to ensure open access to data, database interoperability, and better benefit sharing outcomes.

    • Scarlett Sett
    • W. John Kress
    • Amber Hartman Scholz
    CommentOpen Access
  • Enhancing the clinical trial capabilities within Africa is essential to augment the continent’s pandemic prevention, preparedness and response efforts. Here, we describe the critical challenges of clinical trials in Africa and draw upon the lessons learnt from the Consortium for COVID-19 Vaccine Clinical Trials (CONCVACT) experience, such as the importance of regional collaboration, capacity building and establishing standardized protocols.

    • Nicaise Ndembi
    • Tadesse T. Mekonen
    • John Nkengasong
    CommentOpen Access
  • Human induced pluripotent stem cell-derived models are a well-established preclinical tool, with the ability to retain the genetics of the individual from which they are derived. Here we comment on the global representation and accessibility of such cellular tools from African population groups.

    • Tracey Hurrell
    • Jerolen Naidoo
    • Janine Scholefield
    CommentOpen Access
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