A lattice of protein tetramers

A self-assembling 2D lattice protects replication of a bacterial virus

Some bacterial viruses enclose their replicating DNA in a protein-based ‘phage nucleus’. Nieweglowska et al. show that the structure is a lattice of tetramers linked by flexible loops and tails.


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Latest Research articles

Subjects within Physical sciences

  • This study updates the floristic realms of the world by integrating global distributions and mega-phylogenies of 12,664 angiosperm genera. Eight realms and 16 sub-realms are identified, most of which have formed since the Paleogene, and their formation is dominated by geographic isolation induced by plate tectonics rather than current or historical climate.

    • Yunpeng Liu
    • Xiaoting Xu
    • Zhiheng Wang
    ArticleOpen Access

Subjects within Earth and environmental sciences

  • A major challenge in biotechnology and biomanufacturing is the identification of a set of biomarkers for perturbations and metabolites of interest. Here, the authors develop a data-driven, transcriptome-wide approach to rank perturbation-inducible genes from time-series RNA sequencing data for the discovery of analyte-responsive promoters.

    • Aqib Hasnain
    • Shara Balakrishnan
    • Enoch Yeung
    ArticleOpen Access
  • Currently, NADH oxidases, (NOXs) are the standard regeneration, systems for oxidized nicotinamides but their dependency on O2 limits, their application at industrial scale. Here, the authors established an O2-free system, based on [NiFe] hydrogenase that, regenerates oxidized nicotinamides.

    • Ammar Al-Shameri
    • Dominik L. Siebert
    • Volker Sieber
    ArticleOpen Access
  • Safe delivery of genes is needed for gene therapy. Here the authors build “artificial viral vectors” (AVVs) by engineering the well-characterised structural components of bacteriophage T4: the large capacity, all-in-one, multiplex, programmable, and phage-based AVV nanomaterials have potential for gene therapy.

    • Jingen Zhu
    • Himanshu Batra
    • Venigalla B. Rao
    ArticleOpen Access

Subjects within Biological sciences

Subjects within Health sciences

Subjects within Scientific community and society

  • The samples returned from near-Earth asteroid (162173) Ryugu provide a pristine record of the 4.6 billion years since the birth of the Solar System. The Hayabusa2 initial analysis team has integrated a range of analytical techniques to investigate Ryugu’s organic chemistry. Here, we highlight their latest findings, the potential questions which may be answered, and provide an overview of new prospects in the decade to come.

    • Yasuhiro Oba
    • Yoshinori Takano
    • Hiroshi Naraoka
    CommentOpen Access
  • Identifying topological defects in disordered materials has a profound effect on predicting when and where the material will break. Matteo Baggioli comments a recent publication in Nature Communications, which confirms the existence of defects in glasses and their crucial role for plasticity.

    • Matteo Baggioli
    CommentOpen Access
  • Early detection of immunotherapy-induced tumor response is of major benefit for patients but can be complicated by therapy-induced pseudoprogression. A consensus guideline-iRECIST- was developed as a modification of Response Evaluation Criteria in Solid Tumours (RECIST version 1.1). Here we describe which next steps are required to test its validity and how novel approaches for response criteria might be developed and included.

    • Elena Garralda
    • Scott A. Laurie
    • Elisabeth G. E. de Vries
    CommentOpen Access
  • Issues with data reuse have been recognized in synthetic biology and the broader scientific community. Policies and standards fall short as machine reasoning is not emphasised and enforcement is lacking. We discuss the progress, remaining challenges, and possible solutions.

    • Jeanet Mante
    • Chris J. Myers
    CommentOpen Access
  • Progress to reduce plastic pollution has been painfully slow and the consequent damage to the natural environment and to human health is likely to increase further. This has been because the views and ways of working of four distinct stakeholder communities are not sufficiently well integrated. (1) Scientists, (2) industry, (3) society at large and (4) those making policy and legislation must in future find ways to work together.

    • Richard S. Lampitt
    • Stephen Fletcher
    • Adrian Whyle
    CommentOpen Access

Biotechnology and methods

Papers highlighted here represent a snapshot of some of the recent exciting work published in the area of bioengineering, genome engineering, metabolic engineering, synthetic biology, system and computational biology, cellular biotechnology and imaging, and therapeutic biotechnology.
  • Chuanfu An, Ross Cloney, Cara Eldridge, Philip Lössl, Aline Lueckgen, Doaa Megahed, Anne Mirabella and Lorenzo Righetto


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