Jiří Pospíšil et al.

Bacterial nanotubes as a manifestation of cell death

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Physical sciences

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  • Article
    | Open Access

    Mechanically interlocking dissimilar materials, such as metals and polymers, is a challenging yet promising pathway for designing and fabricating complex systems on the small scale. Here, the authors report a novel interlocking fabrication scheme and showcase the fabrication of microrobots via 3D-lithography.

    • C. C. J. Alcântara
    • , F. C. Landers
    • , S. Kim
    • , C. De Marco
    • , D. Ahmed
    • , B. J. Nelson
    •  & S. Pané
  • Article
    | Open Access

    Optical atomic clocks are useful tools for frequency metrology. Here the authors explore the stability of the atomic clocks and the role of the spin squeezed states for the noise reduction in these clocks.

    • Marius Schulte
    • , Christian Lisdat
    • , Piet O. Schmidt
    • , Uwe Sterr
    •  & Klemens Hammerer
  • Article
    | Open Access

    Shark teeth have short lifespans yet can be subject to significant mechanical damage. Here, the authors report on a site-specific damage mechanism in shark teeth enameloid, which maintains tooth functional shape, providing experimental evidence that tooth architecture may have influenced the diversification of shark ecologies over evolution.

    • Shahrouz Amini
    • , Hajar Razi
    • , Ronald Seidel
    • , Daniel Werner
    • , William T. White
    • , James C. Weaver
    • , Mason N. Dean
    •  & Peter Fratzl

Earth and environmental sciences

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    Compound climate events such as floods and droughts together can cause severe socio-economic impacts. Here, the authors analyse global hazard pairs from 1980–2014 and find global hotspots for the occurrence of compound events.

    • Nina N. Ridder
    • , Andy J. Pitman
    • , Seth Westra
    • , Anna Ukkola
    • , X. Do Hong
    • , Margot Bador
    • , Annette L. Hirsch
    • , Jason P. Evans
    • , Alejandro Di Luca
    •  & Jakob Zscheischler
  • Article
    | Open Access

    The Greenland Ice Sheet is the largest land ice contributor to sea level rise and understanding the long-term glacier response to external forcing is key to improved projections. Here the authors show Greenland’s three largest outlet glaciers will likely exceed current worst-case scenario

    • Shfaqat A. Khan
    • , Anders A. Bjørk
    • , Jonathan L. Bamber
    • , Mathieu Morlighem
    • , Michael Bevis
    • , Kurt H. Kjær
    • , Jérémie Mouginot
    • , Anja Løkkegaard
    • , David M. Holland
    • , Andy Aschwanden
    • , Bao Zhang
    • , Veit Helm
    • , Niels J. Korsgaard
    • , William Colgan
    • , Nicolaj K. Larsen
    • , Lin Liu
    • , Karina Hansen
    • , Valentina Barletta
    • , Trine S. Dahl-Jensen
    • , Anne Sofie Søndergaard
    • , Beata M. Csatho
    • , Ingo Sasgen
    • , Jason Box
    •  & Toni Schenk
  • Article
    | Open Access

    Local human activities can lead to cross-border environmental impacts through the food–energy–water–CO2 nexus. Here, the authors report wide variations in environmental impacts of irrigated agriculture across counties within the North China Plain under different environmental and socioeconomic scenarios.

    • Zhenci Xu
    • , Xiuzhi Chen
    • , Jianguo Liu
    • , Yu Zhang
    • , Sophia Chau
    • , Nishan Bhattarai
    • , Ye Wang
    • , Yingjie Li
    • , Thomas Connor
    •  & Yunkai Li

Biological sciences

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    Active and passive demethylation pathways have been implicated in the genome-wide erasure of 5mC accompanying mammalian preimplantation development. Here the authors reveal a recently evolved, mammalian-specific pathway in which global hypomethylation is achieved by the coupling of active and passive demethylation.

    • Christopher B. Mulholland
    • , Atsuya Nishiyama
    • , Joel Ryan
    • , Ryohei Nakamura
    • , Merve Yiğit
    • , Ivo M. Glück
    • , Carina Trummer
    • , Weihua Qin
    • , Michael D. Bartoschek
    • , Franziska R. Traube
    • , Edris Parsa
    • , Enes Ugur
    • , Miha Modic
    • , Aishwarya Acharya
    • , Paul Stolz
    • , Christoph Ziegenhain
    • , Michael Wierer
    • , Wolfgang Enard
    • , Thomas Carell
    • , Don C. Lamb
    • , Hiroyuki Takeda
    • , Makoto Nakanashi
    • , Sebastian Bultmann
    •  & Heinrich Leonhardt
  • Article
    | Open Access

    Understanding evolutionary constraints in antibiotic resistance is crucial for prediction and control. Here, the authors use high-throughput laboratory evolution of Escherichia coli alongside machine learning to identify trade-off relationships associated with drug resistance.

    • Tomoya Maeda
    • , Junichiro Iwasawa
    • , Hazuki Kotani
    • , Natsue Sakata
    • , Masako Kawada
    • , Takaaki Horinouchi
    • , Aki Sakai
    • , Kumi Tanabe
    •  & Chikara Furusawa

Health sciences

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    Escherichia coli is a major cause of urinary tract infection. Here, Biggel et al. provide a phylogenomic analysis of 907 clinical E. coli isolates and identify the P-fimbriae-encoding locus associated with invasive uropathogenic E. coli isolates.

    • Michael Biggel
    • , Basil B. Xavier
    • , James R. Johnson
    • , Karen L. Nielsen
    • , Niels Frimodt-Møller
    • , Veerle Matheeussen
    • , Herman Goossens
    • , Pieter Moons
    •  & Sandra Van Puyvelde
  • Article
    | Open Access

    PTSD has been associated with DNA methylation of specific loci in the genome, but studies have been limited by small sample sizes. Here, the authors perform a meta-analysis of DNA methylation data from 10 different cohorts and identify CpGs in AHRR that are associated with PTSD.

    • Alicia K. Smith
    • , Andrew Ratanatharathorn
    • , Adam X. Maihofer
    • , Robert K. Naviaux
    • , Allison E. Aiello
    • , Ananda B. Amstadter
    • , Allison E. Ashley-Koch
    • , Dewleen G. Baker
    • , Jean C. Beckham
    • , Marco P. Boks
    • , Evelyn Bromet
    • , Michelle Dennis
    • , Sandro Galea
    • , Melanie E. Garrett
    • , Elbert Geuze
    • , Guia Guffanti
    • , Michael A. Hauser
    • , Seyma Katrinli
    • , Varun Kilaru
    • , Ronald C. Kessler
    • , Nathan A. Kimbrel
    • , Karestan C. Koenen
    • , Pei-Fen Kuan
    • , Kefeng Li
    • , Mark W. Logue
    • , Adriana Lori
    • , Benjamin J. Luft
    • , Mark W. Miller
    • , Jane C. Naviaux
    • , Nicole R. Nugent
    • , Xuejun Qin
    • , Kerry J. Ressler
    • , Victoria B. Risbrough
    • , Bart P. F. Rutten
    • , Murray B. Stein
    • , Robert J. Ursano
    • , Eric Vermetten
    • , Christiaan H. Vinkers
    • , Lin Wang
    • , Nagy A. Youssef
    • , Christine Marx
    • , Gerry Grant
    • , Murray Stein
    • , Xue-Jun Qin
    • , Sonia Jain
    • , Thomas W. McAllister
    • , Ross Zafonte
    • , Ariel Lang
    • , Raul Coimbra
    • , Norberto Andaluz
    • , Lori Shutter
    • , Mark S. George
    • , Mira Brancu
    • , Patrick S. Calhoun
    • , Eric Dedert
    • , Eric B. Elbogen
    • , John A. Fairbank
    • , Robin A. Hurley
    • , Jason D. Kilts
    • , Angela Kirby
    • , Christine E. Marx
    • , Scott D. McDonald
    • , Scott D. Moore
    • , Rajendra A. Morey
    • , Jennifer C. Naylor
    • , Jared A. Rowland
    • , Cindy Swinkels
    • , Steven T. Szabo
    • , Katherine H. Taber
    • , Larry A. Tupler
    • , Elizabeth E. Van Voorhees
    • , Ruth E. Yoash-Gantz
    • , Archana Basu
    • , Leslie A. Brick
    • , Shareefa Dalvie
    • , Nikolaos P. Daskalakis
    • , Judith B. M. Ensink
    • , Sian M. J. Hemmings
    • , Ryan Herringa
    • , Sylvanus Ikiyo
    • , Nastassja Koen
    • , Pei Fen Kuan
    • , Janitza Montalvo-Ortiz
    • , Danny Nispeling
    • , John Pfeiffer
    • , XueJun Qin
    • , Kerry J. Ressler
    • , Dick Schijven
    • , Soraya Seedat
    • , Gen Shinozaki
    • , Jennifer A. Sumner
    • , Patricia Swart
    • , Audrey Tyrka
    • , Mirjam Van Zuiden
    • , Agaz Wani
    • , Erika J. Wolf
    • , Anthony Zannas
    • , Monica Uddin
    •  & Caroline M. Nievergelt
  • Article
    | Open Access

    Ketamine is used for sedation and treatment of depression, but is also a drug of abuse. Here the authors show that ketamine modulates the endocannabinoid system in mice, and that this may contribute to its psychoactive effects.

    • Wei Xu
    • , Hongchun Li
    • , Liang Wang
    • , Jiamei Zhang
    • , Chunqi Liu
    • , Xuemei Wan
    • , Xiaochong Liu
    • , Yiming Hu
    • , Qiyao Fang
    • , Yuanyuan Xiao
    • , Qian Bu
    • , Hongbo Wang
    • , Jingwei Tian
    • , Yinglan Zhao
    •  & Xiaobo Cen

News & Comment

  • Comment
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    Electrochemical carbon dioxide (CO2) reduction has the potential to sustainably produce carbon-based fuels and chemicals while mitigating the increasing levels of CO2 in the atmosphere. In this comment, the author discusses a few basic concepts in the fundamental mechanistic studies of electrochemical CO2 reduction.

    • Karen Chan
  • Comment
    | Open Access

    Over the past 15 years, genome-wide association studies (GWASs) have generated a wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution genome-screens will continue to drive gene discovery in years ahead. Meanwhile, GWAS loci are increasingly translated into new biology and opportunities for clinical care.

    • Ruth J. F. Loos
  • Q&A
    | Open Access

    Dr. Yi Liu is the facility director at the Molecular Foundry, Lawrence Berkeley National Laboratory. Trained as a supramolecular chemist and after a postdoctoral stay and working on click chemistry in Sharpless’s group he started his independent research career working on organic electronics, porous materials, and covalent organic frameworks (COFs). His aim is to develop nanostructured electronic materials through the design, synthesis and manipulation of tailor-made molecular constituents.

  • Q&A
    | Open Access

    Prof. Donglin Jiang is a full professor at the National University of Singapore and is recognized as a pioneer in the field of 2D polymers and covalent organic frameworks (COFs). With a background in chemistry and studies on dendrimers for ten years, the beauty of dendrimers inspired him to consider the possibility of constructing other types of polymers with well-defined shapes and structures. After taking up an associate professorship in 2005 to set up an independent laboratory at the Institute for Molecular Science at the National Institute for Natural Science, he started to dedicate his work on the design, synthesis and functional exploration of 2D polymers, COFs and conjugated microporous polymers.

  • Q&A
    | Open Access

    Professor Xiaodong Zou is a full professor and chair of Inorganic and Structural Chemistry and deputy head of the Department of Materials and Environmental Chemistry at Stockholm University. After completing her PhD in structural chemistry and electron crystallography, she started at the beginning of her independent career to apply these techniques in solving structures of porous materials. She first worked on development of inorganic porous materials, such as zeolites and related open-frameworks. A joint project with Prof. Michael O’Keeffe drew her attention to metal organic frameworks (MOFs), covalent organic frameworks (COFs) and reticular synthesis. Since then, she is working on developing structure characterization techniques for porous materials.

  • Comment
    | Open Access

    Scientists increasingly post images and photos on social media to share their research activities. However, posting images and photos could potentially exclude people with visual impairments. Here, we outline actions that should be taken to foster accessibility and inclusion in posting scientific images on social media.

    • Domenico Chiarella
    • , Justin Yarbrough
    •  & Christopher A.-L. Jackson

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Energy Materials

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Energy Materials

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