The large-scale synthesis of insulating hexagonal boron nitride (hBN) plays an important role for the development of 2D electronics. Here, the authors report the oxygen-assisted chemical vapor deposition of wafer-scale single-crystal monolayer hBN films by merging aligned hexagonal hBN islands.

Dynamic Jahn-Teller effect is rarely realized in condensed matter systems. Here, the authors demonstrate its occurrence in Ba₂MgReO₆, a 5d¹ double perovskite, using resonant inelastic x-ray scattering, thermodynamic measurements and quantum chemistry calculations.

The authors reveal that the incorporation of doping elements with varying electronic structures and ionic radii alters the atomic-scale configuration, thereby affecting the local energy barrier associated with polarization rotation.

Cancer immunotherapy leans on the effective activation on immune response within tumors and surrounding immunosuppressive microenvironment. Here, the authors report a triblock copolymeric nanocarrier encapsulating Resiquimod for B16F10 cell-targeting, which enables in situ tumor vaccination and tumor-associated macrophages polarization.

In the arena of strained heterocyclic chemistry, phosphacycles as appealing electrophilic P-containing building blocks are underestimated. Here, the authors report a class of electrophilic phosphiranium salts bearing fluorinated benzyl quaternizing groups for the direct synthesis of diverselyβ-functionalized phosphines.

The palaeoenvironmental context for early hominins in northern Africa during the Plio-Pleistocene transition is poorly documented. Here, the authors present multiproxy palaeoecological evidence for heterogeneous open grasslands, forested areas, wetlands, and seasonal aridity from Guefaït-4.2 in Morocco.

Mass extinctions have repeatedly restructured communities through geological time, but biotic interactions are rarely considered in investigations of extinction dynamics and ecosystem recovery. Here the authors present evidence that secondary extinction cascades were important during a Jurassic hyperthermal extinction event and that it took over 7 million years for community structure to fully recover.

Combining laser-driven shock compression and ultra-short X-ray pulses from LCLS, the local structure of liquid silicates was determined up to 385 GPa. Compared with molecular dynamics calculations, continuous densification of O-O and Mg-Si networks may alter melt properties and impact planetary differentiation.

Here, the authors show that germ cell transplantation and surrogate production of bluefin tuna sperm in small-bodied fish species shortens the period in which sperm is produced. This study opens the possibility of highly efficient seed production in bluefin tuna.

The study examines how land property rights impact land use efficiency (LUE) globally, based on the SDG 11.3.1 indicator. Secure rights improve LUE, with common law countries outperforming civil law countries, supporting sustainable land management.

By systematically screening viral and bacterial pathogens during co-infection in macrophages, the authors identify and characterize altered host cell entry and suppressed cell death induction as two critical mechanisms that impact infection outcome.

Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Here the authors show that elevated expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), the enzyme driving local bone GC activation, is associated with bone loss and obesity mice.

Triple-negative breast cancers are aggressive tumours, but their prognosis is critically determined by the immune cell activity within the microenvironment, with the more inflamed, hot milieu predicting better prognosis. Here authors show that the tumour draining lymph nodes, even if not invaded by the tumours, reflect the difference between the cold and hot tumours via differential Th2 polarization.

Liu et al. identify a subpellicular microtubule-based dynein motor in ookinetes of Plasmodium. This motor transports the cargos for apical organelle and structure assembly in ookinetes. Dynein-deficient parasites fail ookinete morphogenesis and mosquito transmission of Plasmodium.

The palaeoenvironmental context for early hominins in northern Africa during the Plio-Pleistocene transition is poorly documented. Here, the authors present multiproxy palaeoecological evidence for heterogeneous open grasslands, forested areas, wetlands, and seasonal aridity from Guefaït-4.2 in Morocco.

Cancer immunotherapy leans on the effective activation on immune response within tumors and surrounding immunosuppressive microenvironment. Here, the authors report a triblock copolymeric nanocarrier encapsulating Resiquimod for B16F10 cell-targeting, which enables in situ tumor vaccination and tumor-associated macrophages polarization.

Excessive glucocorticoid (GC) action is linked to various metabolic disorders. Here the authors show that elevated expression of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), the enzyme driving local bone GC activation, is associated with bone loss and obesity mice.

Triple-negative breast cancers are aggressive tumours, but their prognosis is critically determined by the immune cell activity within the microenvironment, with the more inflamed, hot milieu predicting better prognosis. Here authors show that the tumour draining lymph nodes, even if not invaded by the tumours, reflect the difference between the cold and hot tumours via differential Th2 polarization.

Chronic pain remains a major clinical challenge with unclear causes and a need for new treatment. Using the single-cell transcriptomics atlas iPain, here the authors show that nociceptor senescence may drive chronic pain and present senolytics as a potential therapeutic approach.

The study by Fu and colleagues presents a ferritin-adaptor platform for vaccine development, featuring a rabies virus vaccine candidate that enhances antigen stability and provides potent, durable protection after a single-dose administration.

In this work, authors present an integral MCNP model of the ITER facility for radiation transport, addressing limitations of separate models for the Tokamak and Tokamak Complex. This model streamlines safety simulations, enhancing the robustness and simplicity of radiation safety analysis.

The study examines how land property rights impact land use efficiency (LUE) globally, based on the SDG 11.3.1 indicator. Secure rights improve LUE, with common law countries outperforming civil law countries, supporting sustainable land management.

Why people like and share content on social media is poorly understood. Here, the authors investigate social media engagement with posts mentioning identity and expressing ingroup solidarity and outgroup hostility before and after the 2022 Russian invasion of Ukraine.

Memories of our past experiences enable us to reconstruct (in the present) our past better than our future. Here, the authors show that we are also able to better reconstruct the pasts (versus futures) in other people’s lives.