DNA synthesis for true random number generation

Secure data encryption increasingly needs large volumes of true random numbers. Linda Meiser et al. use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.

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Subjects within Physical sciences

  • The Antarctic Peninsula sees some of the strongest warming of the whole continent over the last decades, the drivers of which are not well known. Here, the authors show that winter sea surface temperature increases in the Tasman sea lead to changes in Southern Ocean storm tracks that in turn warm the Antarctic Peninsula.

    • Kazutoshi Sato
    • Jun Inoue
    • Irina Rudeva
    Article Open Access
  • The interplay between continental subduction exhumation dynamics and the obduction of ophiolite sheets remains enigmatic. Here, the authors show that the extrusion of the subducted continental upper crust triggers the necking and breaking of the oceanic upper plate and leads to far-travelled ophiolite sheet emplacement.

    • Kristóf Porkoláb
    • Thibault Duretz
    • Ernst Willingshofer
    Article Open Access

Subjects within Earth and environmental sciences

  • BRCA1 driven breast cancer arises from luminal progenitor cells but how BRCA1 loss-of-function affects the luminal progenitor cell state during premalignant stages of the disease is still unclear. Here, the authors demonstrate an aberrant differentiation of luminal progenitors towards a partial secretory luminal cell phenotype that occurs in a Brca1 deficient mouse model of breast cancer at early stages of tumour initiation and in breast cells from BRCA1 carriers.

    • Karsten Bach
    • Sara Pensa
    • Walid T. Khaled
    Article Open Access
  • Industrial sugarcane ethanol fermentations are accomplished by a microbial community dominated by S. cerevisiae and co-occurring bacteria. Here, the authors investigate how microbial community composition contributes to community function and reveal the role of acetaldehyde in improving yeast growth rate and ethanol production.

    • Felipe Senne de Oliveira Lino
    • Djordje Bajic
    • Morten Otto Alexander Sommer
    Article Open Access
  • ATAC-seq measures chromatin accessibility as a proxy for the activity of DNA regulatory regions across the genome. Here the authors present AtacWorks, a deep learning tool to denoise and identify accessible chromatin regions from low cell count, low-coverage, or low-quality ATAC-seq data.

    • Avantika Lal
    • Zachary D. Chiang
    • Jason D. Buenrostro
    Article Open Access

Subjects within Biological sciences

Subjects within Health sciences

  • The unprecedented cost of the 2018 eruption in Hawai’i reflects an intersection of disparate physical and social phenomena: widely spaced, highly destructive eruptions, and atypically high population growth. These were linked and the former indirectly drove the latter with unavoidable consequences.

    • Bruce F. Houghton
    • Wendy A. Cockshell
    • Eric Yamashita
    Comment Open Access
  • Neural recording technologies increasingly enable simultaneous measurement of neural activity from multiple brain areas. To gain insight into distributed neural computations, a commensurate advance in experimental and analytical methods is necessary. We discuss two opportunities towards this end: the manipulation and modeling of neural population dynamics.

    • Krishna V. Shenoy
    • Jonathan C. Kao
    Comment Open Access
  • Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues. This tool has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.

    • Carla Umansky
    • Agustín E. Morellato
    • Lucas B. Pontel
    Comment Open Access
  • Many newly-discovered microbial phyla have been studied solely by cultivation-independent techniques such as metagenomics. Much of their biology thus remains elusive, because the organisms have not yet been isolated and grown in the lab. Katayama et al. lift the curtain on some intriguing biology by cultivating and studying bacteria from the elusive OP9 phylum (Atribacterota).

    • Muriel C. F. van Teeseling
    • Christian Jogler
    Comment Open Access
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