Jiří Pospíšil et al.

Bacterial nanotubes as a manifestation of cell death

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Physical sciences

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  • Article
    | Open Access

    Telomerase enzymes add telomeric repeats to the end of linear chromosomes. Here the authors reveal mechanisms by which oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation.

    • Samantha L. Sanford
    • , Griffin A. Welfer
    • , Bret D. Freudenthal
    •  & Patricia L. Opresko
  • Article
    | Open Access

    Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity.

    • Mark J. Ranek
    • , Christian Oeing
    • , Rebekah Sanchez-Hodge
    • , Kristen M. Kokkonen-Simon
    • , Danielle Dillard
    • , M. Imran Aslam
    • , Peter P. Rainer
    • , Sumita Mishra
    • , Brittany Dunkerly-Eyring
    • , Ronald J. Holewinski
    • , Cornelia Virus
    • , Huaqun Zhang
    • , Matthew M. Mannion
    • , Vineet Agrawal
    • , Virginia Hahn
    • , Dong I. Lee
    • , Masayuki Sasaki
    • , Jennifer E. Van Eyk
    • , Monte S. Willis
    • , Richard C. Page
    • , Jonathan C. Schisler
    •  & David A. Kass
  • Article
    | Open Access

    Electrification of water upon contact with hydrophobic surfaces is a ubiquitous but poorly understood phenomenon. Here, the authors pinpoint the factors responsible for the excess positive charge carried by water droplets dispensed from hydrophobic capillaries, thereby answering some outstanding questions and raising new ones.

    • Jamilya Nauruzbayeva
    • , Zhonghao Sun
    • , Adair Gallo Jr.
    • , Mahmoud Ibrahim
    • , J. Carlos Santamarina
    •  & Himanshu Mishra

Earth and environmental sciences

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    Comparative analysis of animal behaviour using locomotion data such as GPS data is difficult because the large amount of data makes it difficult to contrast group differences. Here the authors apply deep learning to detect and highlight trajectories characteristic of a group across scales of millimetres to hundreds of kilometres.

    • Takuya Maekawa
    • , Kazuya Ohara
    • , Yizhe Zhang
    • , Matasaburo Fukutomi
    • , Sakiko Matsumoto
    • , Kentarou Matsumura
    • , Hisashi Shidara
    • , Shuhei J. Yamazaki
    • , Ryusuke Fujisawa
    • , Kaoru Ide
    • , Naohisa Nagaya
    • , Koji Yamazaki
    • , Shinsuke Koike
    • , Takahisa Miyatake
    • , Koutarou D. Kimura
    • , Hiroto Ogawa
    • , Susumu Takahashi
    •  & Ken Yoda
  • Article
    | Open Access

    Chattering dust, or chemically reactive grains of sucrose containing pockets of pressurized carbon dioxide, are used in this experimental approach to study rock fractures. The chattering dust emits acoustic shocks that can be monitored and illuminates fracture geometry.

    • Laura J. Pyrak-Nolte
    • , William Braverman
    • , Nicholas J. Nolte
    • , Alan J. Wright
    •  & David D. Nolte

Biological sciences

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    | Open Access

    In neural development, progenitors transition from a proliferative to a differentiated state. Here, the authors show that cerebellar granule neurons retract primary cilia as they exit their proliferative niche upon decreased ECM engagement, enabling radial migration due to loss of Shh sensitivity.

    • Taren Ong
    • , Niraj Trivedi
    • , Randall Wakefield
    • , Sharon Frase
    •  & David J. Solecki
  • Article
    | Open Access

    Telomerase enzymes add telomeric repeats to the end of linear chromosomes. Here the authors reveal mechanisms by which oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation.

    • Samantha L. Sanford
    • , Griffin A. Welfer
    • , Bret D. Freudenthal
    •  & Patricia L. Opresko
  • Article
    | Open Access

    Previous research on the importance of prosociality is based on observations from WEIRD societies, questioning the generalizability of these findings. Here the authors present a global investigation of the relation between prosociality and labor market success and generalize the positive relation to a wide geographical context.

    • Fabian Kosse
    •  & Michela M. Tincani

Health sciences

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  • Article
    | Open Access

    Telomerase enzymes add telomeric repeats to the end of linear chromosomes. Here the authors reveal mechanisms by which oxidized dNTPs and therapeutic dNTPs inhibit telomerase-mediated telomere elongation.

    • Samantha L. Sanford
    • , Griffin A. Welfer
    • , Bret D. Freudenthal
    •  & Patricia L. Opresko
  • Article
    | Open Access

    Carboxyl terminus of Hsc70-interacting protein (CHIP) is proteostasis regulator. Here the authors show that CHIP-mediated protein turnover is enhanced by PKG-mediated phosphorylation, which results in attenuated cardiac ischemic proteotoxicity.

    • Mark J. Ranek
    • , Christian Oeing
    • , Rebekah Sanchez-Hodge
    • , Kristen M. Kokkonen-Simon
    • , Danielle Dillard
    • , M. Imran Aslam
    • , Peter P. Rainer
    • , Sumita Mishra
    • , Brittany Dunkerly-Eyring
    • , Ronald J. Holewinski
    • , Cornelia Virus
    • , Huaqun Zhang
    • , Matthew M. Mannion
    • , Vineet Agrawal
    • , Virginia Hahn
    • , Dong I. Lee
    • , Masayuki Sasaki
    • , Jennifer E. Van Eyk
    • , Monte S. Willis
    • , Richard C. Page
    • , Jonathan C. Schisler
    •  & David A. Kass
  • Article
    | Open Access

    Here, the authors apply genetic fate mapping and temporal clonal analysis to study progenitor recruitment and network morphogenesis of murine cardiac Purkinje fibers. Additionally, they characterize how transcription factor dosage regulates cell fate divergence during distinct phases of this process.

    • Caroline Choquet
    • , Robert G. Kelly
    •  & Lucile Miquerol

News & Comment

  • Comment
    | Open Access

    The human body supports a thriving diversity of microbes which comprise a dynamic, ancillary, functional system that synergistically develops in lock-step with physiological development of its host. The human microbiome field has transitioned from cataloging this rich diversity to dissecting molecular mechanisms by which microbiomes influence human health. Early life microbiome development trains immune function. Thus, vertically, horizontally, and environmentally acquired microbes and their metabolites have the potential to shape developmental trajectories with life-long implications for health.

    • Elze Rackaityte
    •  & Susan V. Lynch
  • Comment
    | Open Access

    Low-temperature carbon dioxide electrolysis is an attractive process for sustainable fuel synthesis, but current systems suffer from low efficiency. In this comment, authors discuss the limitations arising from the reaction between carbon dioxide and hydroxide, highlighting the need for new research to address this fundamental problem.

    • Joshua A. Rabinowitz
    •  & Matthew W. Kanan
  • Comment
    | Open Access

    Synthetic biology is among the most hyped research topics this century, and in 2010 it entered its teenage years. But rather than these being a problematic time, we’ve seen synthetic biology blossom and deliver many new technologies and landmark achievements.

    • Fankang Meng
    •  & Tom Ellis
  • Comment
    | Open Access

    Protected areas (PAs) are the most important conservation tool, yet assessing their effectiveness is remarkably challenging. We clarify the links between the many facets of PA effectiveness, from evaluating the means, to analysing the mechanisms, to directly measuring biodiversity outcomes.

    • Ana S. L. Rodrigues
    •  & Victor Cazalis
  • Comment
    | Open Access

    Myelinating Schwann cells control the diameter of the axons they ensheath by an unknown mechanism. In a recent article in Nature Communications, Eichel and colleagues identify the tetraspan protein CMTM6 as a regulator of axonal caliber.

    • Nimrod Elazar
    •  & Elior Peles
  • Q&A
    | Open Access

    Dr. Kishana Taylor (a microbiologist and Postdoctoral Researcher at the University of California, Davis), Dr. Nella Vargas-Barbosa (an electrochemist and Scientist at the Max Planck Institute) and Dr. Anouk Beniest (a geologist and Postdoctoral Researcher at GEOMAR Helmholtz Centre for Ocean Research Kiel) talked to Nature Communications about their recent experiences at virtual conferences as early career researchers, since the onset of international COVID-19 travel restrictions. Kishana, Nella and Anouk share tips for navigating virtual conferences as junior researchers, and they also give suggestions for conference organizers to improve virtual scientific meetings so they more inclusive for younger scientists.

Focus

Therapeutics

Jaeok Park et al./doi:10.1038/ncomms14132

Therapeutics

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