Sleeping sickness is a disease caused by Trypanosoma parasites. Mabille et al. study how the parasites (colourized in the image) affect respiratory function and lung immune responses.
Starting in 2016, we have offered authors the option to publish the comments received from the reviewers and their responses alongside the paper. As we believe that transparency strengthens the quality of peer review, we are now moving to publish the exchanges between authors and reviewers for all research articles submitted from November 2022 onward and accepted for publication. Referees will still have the option to remain completely anonymous, to sign their reports, and/or to choose to be acknowledged by name as part of our reviewer recognition scheme.
Rigorous, robust replication and generalization studies present a significant investment into the quality of the research record, the foundation on which new research is built. Communications Psychology and the Human Behaviour Team at Nature Communications are inviting submissions of replication studies in psychology and the human behavioural sciences.
Over the last two and a half years, Nature Communications has received thousands of submissions related to the COVID-19 pandemic and accepted hundreds for publication. To showcase the breadth and quality of this work, we are now launching a COVID-19 Collection, and here we reflect on our editorial processes during this period.
Our Community Voices series aims to highlight the challenges faced by under-represented groups in scientific research and to provide a platform to share possible solutions, to work towards a more diverse and equitable research landscape.
Our editors highlight articles they see as particularly interesting or important in these new pages spanning all research areas.
Nature Communications has a 2-year impact factor of 17.7 (2021), article downloads of 85,307,200 (2021), and 8 days from submission to the first editorial decision.
This Collection highlights recent publications in Nature Communications and Communications Materials on the discovery of natural materials and their potential applications as biomaterials. We also highlight how lessons learned from Nature can help develop advanced biomimetic materials, and explore their diverse applicationsOpen for submissions
In this joint Collection, Nature Communications and Communications Medicine invite submissions of primary research that aims to understand and improve child and adolescent development and health.Open for submissions
Latest Research articles
Paired electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling between α-chloroesters and aryl bromides
Precise matching of reaction rate and electric potential of electrodes in paired electrolysis is challenging. Here, the authors develop paired-electrolysis-enabled nickel-catalyzed enantioselective reductive cross-coupling of α-chloroesters and aryl bromides.
Thiocarbazate building blocks enable the construction of azapeptides for rapid development of therapeutic candidates
The rapid protease degradation of peptides is currently limiting their therapeutic utility. Here, the authors report functionalised thiocarbazate scaffolds as precursors of aza-amino acids that can be integrated in peptide sequences, extending their bioavailability, and demonstrate this on FSSE/P5779 and bradykinin.
In flat band materials, the ’flat’ dispersion of the electronic states mean that interactions between electrons can be strong, potentially leading to a variety of interesting magnetic and transport properties. Here, Nag et al study the Kagomé semimetal Co3Sn2S2, and show a nearly flat Stoner excitation dispersion, a clear indication of spin-polarized and flat electronic bands.
Modular stimuli-responsive hydrogel sealants for early gastrointestinal leak detection and containment
Digestive surgical leaks manifesting days after a successful surgery can lead to severe complications and affect healthcare worldwide. Here, the authors address the problem holistically with a hydrogel patch capable of sealing tissues, while detecting imminent leaks via a smartphone-operated ultrasound probe.
Energy cascades in donor-acceptor exciton-polaritons observed by ultrafast two-dimensional white-light spectroscopy
Exciton-polaritons are hybridized light-matter states that exhibit intriguing phenomena that are unobserved in purely excitonic states. Here, the authors elucidate the photophysical mechanism of polariton-assisted long-range energy transfer in carbon nanotubes using two-dimensional white-light spectroscopy and quantum calculations.
- Astronomy and planetary science
- Energy science and technology
- Materials science
- Mathematics and computing
- Nanoscience and technology
- Optics and photonics
A new model elucidates the connections between silent earthquakes ("slow slip events") and regular ones by accounting for their finite rupture depth. It reconciles debated features of slow slip events and explains how they might lead to earthquakes.
Using satellite observations, the authors show that the average tropical cyclone (TC) rain rate increases significantly with translation speed. On average, the rain rate of a fast-moving TC is about 24% higher than that of a slow one.
Geochemical data from sedimentary rocks in Siberia indicate that members of the soft-bodied Ediacara biota (the earliest macroscopic life on Earth) were tolerant of low-oxygen conditions, suggesting they had the capacity for anaerobic metabolisms.
Multiproxy SST reconstructions of the Western Pacific Warm Pool show cooling over the entire last 10 Ma. High latitude Pacific Ocean SSTs are shown to be amplified, warming 2.4 °C per 1° of warming in the WPWP. This is reproduced by climate models.
Aerobic oxidation of methane significantly reduces global diffusive methane emissions from shallow marine waters
Aerobic oxidation is a biological sink of methane that can reduce oceanic emissions to the atmosphere. This study estimates that half of methane from total loss, amounting to 1.8 ± 2.7 Tg, is oxidized annually in global 0–50 m near-shore waters
- Climate sciences
- Environmental sciences
- Environmental social sciences
- Natural hazards
- Ocean sciences
- Planetary science
- Solid Earth sciences
- Space physics
LATS1 is reported to regulate the transition of luminal-basal-like cell plasticity in breast cancer. Here the authors report that LATS1 limits the progression of luminal breast cancer by associating with NCOR1 nuclear corepressor to repress ERα-downregulated genes in luminal cells.
Hydrophobicity of arginine leads to reentrant liquid-liquid phase separation behaviors of arginine-rich proteins
Arginine-rich proteins display reentrant LLPS behavior with changes in salt and temperature due to the hydrophobicity of arginine. Controlling the reentrant LLPS behavior opens avenues for the bioengineering and drug delivery fields.
La proteins are conserved factors critical for the maturation of RNA polymerase III transcripts. In the ciliate T. thermophila and related alveolates, La proteins have a novel domain arrangement and are linked to a distinct pre-tRNA processing pathway.
Tree peony (Paeonia ostii) has the largest chromosome of any sequenced plants to date. Here, the authors assemble its genome and reveal the association of a list of candidate genes with fatty acid biosynthesis and the possible contribution of transposon and histone expansion to maintain the giga-chromosomes.
Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiation state and clinical outcome.
- Biological techniques
- Cell biology
- Chemical biology
- Computational biology and bioinformatics
- Developmental biology
- Drug discovery
- Molecular biology
- Plant sciences
- Stem cells
- Structural biology
- Systems biology
High antibody levels and reduced cellular response in children up to one year after SARS-CoV-2 infection
Severity of SARS-CoV-2 infection is different in adults and children which involves the immune response. Here using a parent and children cohort with 4 month and 12 month sampling times, the authors show enhanced levels and increased breadth of anti-spike antibody level over time but reduced specific T cell and B cell numbers in children.
Low-dose IL-2 reduces IL-21+ T cell frequency and induces anti-inflammatory gene expression in type 1 diabetes
Low-dose interleukin-2 is showing promise in the treatment of several autoimmune inflammatory diseases. Here authors map the trajectory of cellular and transcriptional changes in type 1 diabetes patients receiving an interval dosing interleukin-2 regimen, which shows an anti-inflammatory gene expression signature shared by all immune cell types analysed, persisting for at least a month after ending treatment.
Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome. Here the authors implicate the mechanistic target of rapamycin complex 1 in murine models of Still’s disease and macrophage activation syndrome, and provide associations with clinical cases in patients
Inflammation promotes resistance to immune checkpoint inhibitors in high microsatellite instability colorectal cancer
Inflammatory conditions often affect colorectal cancer patients, and their effect on their ongoing treatment is a pressing medical question. Here authors show that inflammation interferes with local anti-tumour immune response and inhibits response to immune checkpoint blockade therapy via immunosuppressive neutrophil leukocytes.
Renal tubular epithelial cells (TECs) can initiate an adaptive or maladaptive response after injuries of different severity. Here, the authors elucidate a chromatin-mediated mechanism underlying the responses of TECs to varying kidney injuries.
- Health care
- Health occupations
- Medical research
- Molecular medicine
- Risk factors
- Signs and symptoms
Misinformation online can be shared by major political figures and organizations. Here, the authors developed a method to measure exposure to information from these sources on Twitter, and show how exposure relates to the quality of the content people share and their political ideology.
The COVID-19 pandemic has stimulated an important changes in online information access. Here, the authors analyse everyday web search interactions across 25,150 US ZIP codes revealing significant differences in how digital informational resources are mobilized by different communities.
Systemic risk and bank bailout approaches have been the source of discussions on scientific, financial and governmental forums. An artificial intelligence technique is proposed to inform equitable bailout decisions that minimise taxpayers’ losses.
In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.
While it is widely acknowledged that Darwin’s descriptions of females were gender-biased, gender bias in modern sexual selection research is less recognized. This Perspective highlights that sexual selection theory and research are still male-centered and suggest strategies for alleviating biases in this field and beyond.
Since 2020 Nature Communications has been considering Registered Reports for publication in the areas of cognitive neuroscience, human behaviour and psychology, and epidemiology. We are excited to announce the publication of our first Registered Report. With this milestone, we also want to open the format to all other areas of research.
We recently published our first Registered Report entitled ‘Value-free random exploration is linked to impulsivity’. We believe the format offers many benefits to strengthen hypothesis-driven research and are keen to share our experience with our readers as we open up the format to all fields of research. We interviewed the authors of the manuscript (Magda Dubois and Tobias Hauser) and one of the reviewers (Trevor Robbins) about their experience of the review process. We are editorially committed to take their comments on board to further improve our guidance and to optimally support our future authors.
Nature Communications is now welcoming Registered Report submissions from all fields of research (read our editorial here), and we want to encourage submissions from the ecology and evolutionary biology fields. To introduce this format to researchers in those fields, we interviewed two founding members of the Society for Open, Reliable, and Transparent Ecology and Evolutionary Biology (SORTEE), a network of researchers aimed at improving research practices in ecology, evolutionary biology, and related fields: Shinichi Nakagawa (Professor of Evolutionary Ecology and Synthesis at the University of New South Wales, UNSW) and Rose O’Dea (Secretary of SORTEE, postdoctoral researcher and fellow at the Wissenschaftskolleg zu Berlin). Below, they share their thoughts on how the fields of ecology and evolutionary biology can advance in reproducibility and transparency.
While there are a growing number of human pluripotent stem cell repositories, genetic diversity remains limited in most collections and studies. Here, we discuss the importance of incorporating diverse ancestries in these models to improve equity and accelerate biological discovery.
Rivers and streams are increasingly drying with climate change and biogeochemical impacts may be important. In this comment the authors discuss the challenges to the biogeochemistry of non-perennial rivers and streams, and what can be done to tackle them.
Financing of urban greening has traditionally prioritized economic growth. Here the authors argue for action to ensure more socially just green financing.
Trending - Altmetric
Early-career setback and future career impact
Neovenatorid theropods are apex predators in the Late Cretaceous of North America
Mapping the effects of pregnancy on resting state brain activity, white matter microstructure, neural metabolite concentrations and grey matter architecture
How people wake up is associated with previous night’s sleep together with physical activity and food intake