Matteo Malinverno et al.

Development of blood vessel malformations in the brain

Latest Research

Physical sciences

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  • Article
    | Open Access

    HiChIP/PLAC-seq assay is popular for profiling 3D genome interactions among regulatory elements at kilobase resolution. Here the authors describe FitHiChIP an empirical null-based, flexible computational method for statistical significance estimation and loop calling from HiChIP data.

    • Sourya Bhattacharyya
    • , Vivek Chandra
    • , Pandurangan Vijayanand
    •  & Ferhat Ay
  • Article
    | Open Access

    Van der Waals heterostructures may offer a suitable platform for all-optical manipulation of valleytronic devices. Here, the authors observe a strong enhancement of the valley magnetic response in MoS2, and magnetic tuning of the polarization of MoS2 direct optical transition

    • Jing Zhang
    • , Luojun Du
    • , Shun Feng
    • , Run-Wu Zhang
    • , Bingchen Cao
    • , Chenji Zou
    • , Yu Chen
    • , Mengzhou Liao
    • , Baile Zhang
    • , Shengyuan A. Yang
    • , Guangyu Zhang
    •  & Ting Yu
  • Article
    | Open Access

    Development of light-responsive materials imposes a demand on visible-light photoswitching but this is often achieved at expense of photochromic performance. Here the authors use a building-block design to achieve a diarylethene all-visible-light photoswitch with improved photochromic efficiency and enhanced photo-fatigue resistance.

    • Zhiwei Zhang
    • , Wenhui Wang
    • , Peipei Jin
    • , Jiadan Xue
    • , Lu Sun
    • , Jinhai Huang
    • , Junji Zhang
    •  & He Tian

Earth and environmental sciences

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  • Article
    | Open Access

    Alkaline lakes have some of the highest productivity rates in freshwater ecosystems. Here the authors report amplicon, metagenome, and proteome sequencing from microbial mat communities of four alkaline lakes in Canada, and compare these lakes to central Asian soda lakes, revealing a shared core microbiome despite the geographical distance.

    • Jackie K. Zorz
    • , Christine Sharp
    • , Manuel Kleiner
    • , Paul M. K. Gordon
    • , Richard T. Pon
    • , Xiaoli Dong
    •  & Marc Strous
  • Article
    | Open Access

    The fish Astyanax mexicanus has divergent cave and river-dwelling eco-morphotypes. Here, Hyacinthe et al. show that cave and river fish communicate sonically, but that the sounds produced and the responses elicited in the two morphs depend differently on the social and behavioral context.

    • Carole Hyacinthe
    • , Joël Attia
    •  & Sylvie Rétaux
  • Article
    | Open Access

    Coral populations from thermally extreme conditions may help restore reefs degraded by bleaching. Here, the authors show that these corals can maintain their heat tolerance despite acclimation to colder temperatures but have a limited capacity to acclimatize to ocean warming.

    • Verena Schoepf
    • , Steven A. Carrion
    • , Svenja M. Pfeifer
    • , Melissa Naugle
    • , Laurence Dugal
    • , Jennifer Bruyn
    •  & Malcolm T. McCulloch

Biological sciences

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  • Article
    | Open Access

    Alkaline lakes have some of the highest productivity rates in freshwater ecosystems. Here the authors report amplicon, metagenome, and proteome sequencing from microbial mat communities of four alkaline lakes in Canada, and compare these lakes to central Asian soda lakes, revealing a shared core microbiome despite the geographical distance.

    • Jackie K. Zorz
    • , Christine Sharp
    • , Manuel Kleiner
    • , Paul M. K. Gordon
    • , Richard T. Pon
    • , Xiaoli Dong
    •  & Marc Strous
  • Article
    | Open Access

    Comparative genomic analysis of human and primate relatives can reveal important biological and evolutionary insights. Here, the authors present a long-read assembly of the Chinese rhesus macaque genome and identify ape-specific structural variants.

    • Yaoxi He
    • , Xin Luo
    • , Bin Zhou
    • , Ting Hu
    • , Xiaoyu Meng
    • , Peter A. Audano
    • , Zev N. Kronenberg
    • , Evan E. Eichler
    • , Jie Jin
    • , Yongbo Guo
    • , Yanan Yang
    • , Xuebin Qi
    •  & Bing Su
  • Article
    | Open Access

    The fish Astyanax mexicanus has divergent cave and river-dwelling eco-morphotypes. Here, Hyacinthe et al. show that cave and river fish communicate sonically, but that the sounds produced and the responses elicited in the two morphs depend differently on the social and behavioral context.

    • Carole Hyacinthe
    • , Joël Attia
    •  & Sylvie Rétaux

Health sciences

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  • Article
    | Open Access

    Exposure to air pollution during pregnancy has been associated with impaired birth outcomes. Here, Bové et al. report evidence of black carbon particle deposition on the fetal side of human placentae, including at early stages of pregnancy, suggesting air pollution could affect birth outcome through direct effects on the fetus.

    • Hannelore Bové
    • , Eva Bongaerts
    • , Eli Slenders
    • , Esmée M. Bijnens
    • , Nelly D. Saenen
    • , Wilfried Gyselaers
    • , Peter Van Eyken
    • , Michelle Plusquin
    • , Maarten B. J. Roeffaers
    • , Marcel Ameloot
    •  & Tim S. Nawrot
  • Article
    | Open Access

    Stress kinases are activated in peripheral ischemic tissues in the presence of vascular diseases. Here the authors show that inhibition of the neural JNK3 kinase improves recovery from hind limb ischemia in animals through activation of the transcription factors Egr1/Creb1 and upregulation of growth factors.

    • Shashi Kant
    • , Siobhan M. Craige
    • , Kai Chen
    • , Michaella M. Reif
    • , Heather Learnard
    • , Mark Kelly
    • , Amada D. Caliz
    • , Khanh-Van Tran
    • , Kasmir Ramo
    • , Owen M. Peters
    • , Marc Freeman
    • , Roger J. Davis
    •  & John F. Keaney Jr.
  • Article
    | Open Access

    The use of PET for detection of Aβ in the brain in AD has limitations; studies also indicate that retinal changes, including Aβ deposition, occur in AD. Here the authors demonstrate the potential to use in vivo retinal hyperspectral imaging as a surrogate for brain accumulation of Aβ.

    • Xavier Hadoux
    • , Flora Hui
    • , Jeremiah K. H. Lim
    • , Colin L. Masters
    • , Alice Pébay
    • , Sophie Chevalier
    • , Jason Ha
    • , Samantha Loi
    • , Christopher J. Fowler
    • , Christopher Rowe
    • , Victor L. Villemagne
    • , Edward N. Taylor
    • , Christopher Fluke
    • , Jean-Paul Soucy
    • , Frédéric Lesage
    • , Jean-Philippe Sylvestre
    • , Pedro Rosa-Neto
    • , Sulantha Mathotaarachchi
    • , Serge Gauthier
    • , Ziad S. Nasreddine
    • , Jean Daniel Arbour
    • , Marc-André Rhéaume
    • , Sylvain Beaulieu
    • , Mohamed Dirani
    • , Christine T. O. Nguyen
    • , Bang V. Bui
    • , Robert Williamson
    • , Jonathan G. Crowston
    •  & Peter van Wijngaarden

News & Comment

  • Editorial
    | Open Access

    Originally designed for measuring isotope abundances and elemental masses, mass spectrometry is becoming a mainstay across life sciences. As electrospray ionization of biomolecules turns 30 and the Orbitrap mass analyzer 20, we take this opportunity to highlight the role of both inventions in stirring mass spectrometry from physics into biology and discuss the advances and challenges that may impact the future applications of biomolecular mass spectrometry.

  • Comment
    | Open Access

    John Fenn’s electrospray mass spectrometry (ESMS) was awarded the chemistry Nobel Prize in 2002 and is now the basis of the entire field of MS-based proteomics. Technological progress continues unabated, enabling single cell sensitivity and clinical applications.

    • Matthias Mann
  • Comment
    | Open Access

    The establishment of the Orbitrap analyzer as a major player in mass spectrometry based proteomics is traced back to the first public presentation of this technology 20 years ago; when a proof-of-principle application led the way to further advancements and biological applications.

    • Alexander Makarov
  • Comment
    | Open Access

    The health of the city depends on how well all the elements of this system are interconnected and operating in harmony. Here the authors introduced the concept of urbanome which is analogous to the human genome that can be used to characterise the form and functioning of cities.

    • Lidia Morawska
    • , Wendy Miller
    • , Matt Riley
    • , Sotiris Vardoulakis
    • , Yong-Guan Zhu
    • , Guy B. Marks
    • , Prachi Garnawat
    • , Prashant Kumar
    •  & Marie Thynell
  • Comment
    | Open Access

    Forecasting is beginning to be integrated into decision-making processes for infectious disease outbreak response. We discuss how technologies could accelerate the adoption of forecasting among public health practitioners, improve epidemic management, save lives, and reduce the economic impact of outbreaks.

    • Dylan B. George
    • , Wendy Taylor
    • , Jeffrey Shaman
    • , Caitlin Rivers
    • , Brooke Paul
    • , Tara O’Toole
    • , Michael A. Johansson
    • , Lynette Hirschman
    • , Matthew Biggerstaff
    • , Jason Asher
    •  & Nicholas G. Reich
  • Comment
    | Open Access

    While the crisis of statistics has made it to the headlines, that of mathematical modelling hasn’t. Something can be learned comparing the two, and looking at other instances of production of numbers.Sociology of quantification and post-normal science can help.

    • Andrea Saltelli

Focus

Genomes and Epigenomes

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Genomes and Epigenomes

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Ian Green, Carolina Perdigoto, Lin Tang and Michelle Trenkmann

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