Atomically dispersed metallic materials attract tremendous attention. Here the authors explore a general method based on the discrepancy in cohesive energy of the metals to synthesize a large library of bi-/multi-metallic single atom/atomic cluster materials for electrocatalytic hydrogen evolution.

Lithium dendrite growth in solid-state electrolytes is a significant challenge for next-generation battery development. Here, authors used dark-field X-ray microscopy to investigate dislocations near dendrite tips, suggesting that stress-induced dislocation may influence dendrite branching and material fracture.

The development of metal-free organic X-ray scintillators combining X-ray absorption, efficient exciton utilization, and short luminescence lifetimes, remains challenging. Here, the authors present a strategy for achieving augmented X-ray scintillation through the utilization of halogenated open-shell organic radical scintillators.

Near-infrared transparent films have a number of applications, but combining elimination of UV-vis light and the balance of film thickness and transmittance is challenging. Here, the authors report the development of a thin material with good transmittance and a suitable wavelength cutoff.

Kagome-lattice systems host a variety of condensed matter phenomena. Here, the authors use NMR spectroscopy to probe the orbital-selective modulations of the local density of states in the charge density wave phase of ScV₆Sn₆.

Lab experiments reveal that slow-slip events, generated by heterogeneity in fault composition, can trigger earthquakes by acting as an initial rupture. The slow-slip region can extend beyond the heterogeneity depending on loading conditions.

This study shows that the formation of bottom water and the related sea ice processes in the Ross Sea are significantly affected by major climate patterns in the southern hemisphere’s extratropical regions.

The probability of exceeding various climate thresholds has been calculated. While the warmest future scenario has less than a 1 percent chance of being exceeded this century, the paper discusses why such warm scenarios are still relevant.

Soil properties and functions are both affected by many global change factors. Here, the authors use a microcosm experiment to demonstrate that the number of these factors as well as their dissimilarity were important for predicting the impacts of global change factors.

Microbial communities rely on metabolic interactions to survive in extreme environments. This study shows that rising temperatures increase these interactions, particularly between less related species, highlighting the role of metabolic cooperation in microbial adaptation to thermal stress.

New molecular technologies have helped unveil facets of the genome beyond the canonical proteome, such as microproteins and short ORFs, products of alternative splicing, regulatory non-coding RNAs, transposable elements, and cis-regulatory DNA. In this Review, Gervais & Shapiro highlight what is known about this ‘hidden genome’ in fungi.

Planarians are model systems for stem cells and regeneration. This study provides new genome assemblies of the model species S. mediterranea and 3 relatives and uses comparative genomics of planarians to reveal that synteny is not an evolutionary constraint in flatworm genome evolution.

In the United States, Black patients have higher rates of cancer mortality, but the sources of such disparities remain poorly understood. Here, the authors analyze genomic data from large-scale patient cohorts and find that cancers from self-reported Black patients are significantly more likely to exhibit whole genome duplications; they also explore a potential link to environmental exposures.

Antineutrophil cytoplasmic antibody (ANCA) is currently treated with broad-spectrum immune suppressive drugs. Here the authors decipher inflammatory niches in the kidney of patients with ANCA-GN by combining spatial and single-cell transcriptomics to identify ustekinumab as a promising treatment option and successfully treat four ANCA-GN patients.

Phagocytosis is regulated by the mechanical properties of both the phagocyte and its cargo. Here, the authors show that macrophages employ β2 integrins to sense the rigidity of phagocytic cargo and then mount the appropriate form of engulfment.

Antineutrophil cytoplasmic antibody (ANCA) is currently treated with broad-spectrum immune suppressive drugs. Here the authors decipher inflammatory niches in the kidney of patients with ANCA-GN by combining spatial and single-cell transcriptomics to identify ustekinumab as a promising treatment option and successfully treat four ANCA-GN patients.

In the United States, Black patients have higher rates of cancer mortality, but the sources of such disparities remain poorly understood. Here, the authors analyze genomic data from large-scale patient cohorts and find that cancers from self-reported Black patients are significantly more likely to exhibit whole genome duplications; they also explore a potential link to environmental exposures.

Here, the authors isolate a SARS-CoV-2 mutant that has developed decreased sensitivity to Paxlovid and remdesivir from an immunocompromised patient, show that drug resistance can be overcome by simultaneous treatment with both drugs in vitro, and demonstrate that the drug resistant virus can efficiently transmit in the hamster model.

The genetic characterisation of mixed phenotype acute leukemia (MPAL) remains limited. Here, single cell multi-omics analysis of 14 adult MPAL patients identifies a stem cell-like transcriptomic signature expressed by MPAL blasts that is indicative of high differentiation potential and gives rise to a gene set score MPAL95 that is predictive of survival.

Formation of urate and calcium pyrophosphate micro-crystals is responsible for painful inflammatory flares in gout and chondrocalcinosis. Here the authors show that the osmo-sensitive LRRC8 anion channel is involved with macrophage inflammasome activation by crystals involving cell volume regulation and ATP release leading to P2Y receptor activation.

Van Ouwerkerk and colleagues examine the benefits of renewable energy investments for German households during the recent energy crisis. They find a typical household with a heat pump saved 1850 € and reduced emissions by 250 g/kWh annually, leading to greater gains in resilience when compared to temporary price breaks on energy.

Being born to a family with low-income has been related to lower socioeconomic status attainment in adulthood. Here, the authors report the effects of exposure to a family income transfer in an American Indian population on educational outcomes of the next generation of children.

This study finds that U.S. vehicle assembly plants that have fully transitioned from gas engine to electric vehicle assembly have required higher labor intensity. It suggests that more, not fewer, workers are needed for electric vehicle assembly.

One quarter of households globally owns air-conditioning, but this could reach 41% by 2050. Yet, access and use will remain highly unequal. Electricity demand for air-conditioning will double, potentially increasing global CO2 emissions.