Sequential incompatible measurements on a quantum state would need a full multi-time generalisation of quasiprobability in order to be adequately described. Here, the authors propose such a framework, and test it on a trapped-ion system measuring up to three-time correlation functions.

The authors investigate the X-ray-induced electron dynamics, on the sub-femtosecond timescale, of hydrated Na⁺, Mg²⁺, and Al³⁺ ions providing insights into the ultrafast charge-transfer processes in aqueous environments.

Differential carbohydrate metabolism elicits distinct pyrazine and pyrazinone autoinducer signalling pathways in Klebsiella oxytoca, which impact bacterial virulence programs.

The forecasting of critical phenomena in complex systems governed by partial differential equations remains challenging and computationally expensive. The authors propose a generative learning approach for the forecasting of the statistical properties of high-dimensional systems at a reduced computational cost.

Wide-bandgap perovskite solar cells suffer from severe open-circuit voltage loss with increasing bromine content. Here, authors tackle this issue through homogeneous halogen-phase distribution realized by bottom-up templated crystallization and demonstrate tandem devices with efficiency of 28.08%.

Methyl bromide (CH₃Br) is an important ozone-depleting substance whose use is regulated under the Montreal Protocol. However, the spatial-temporal patterns of China’s national CH₃Br emissions remain unclear. Here, the authors find that China’s top-down emission estimates exceed bottom-up estimates by 60%.

The deep-water cycle in the mantle enhances chemical reactions between mantle minerals and the metallic core, contributing to seismic anomalies observed at the core-mantle boundary, according to high-pressure/temperature multi-anvil experiments.

Microbes and viruses inhabit the subseafloor crust beneath hydrothermal vents. Here the authors show that vent endemic animals such as giant tubeworms also live in vent subseafloor cavities, implicating subseafloor dispersal of vent larvae and the need to protect seafloor and subseafloor vent habitats.

Explainable Artificial Intelligence can improve conservation decisions by revealing hidden insights to where human impacts on biodiversity are greatest. In this investigation of freshwater fish in Switzerland, around 90% of potentially habitable areas were negatively impacted human influences - these areas form the species’ “shadow distribution”.

This study reveals that winter soil warming causes significant crop biomass carbon loss due to soil organic matter degradation. Ignoring this effect could lead to a 4-19% overestimation of future food production.

Differential carbohydrate metabolism elicits distinct pyrazine and pyrazinone autoinducer signalling pathways in Klebsiella oxytoca, which impact bacterial virulence programs.

Structure-based drug discovery of cereblon (CRBN)-recruiting protein degraders has been to date challenging due to limitations with current constructs for recombinant protein expression. In this work, the authors design and validate a truncated CRBN construct, CRBNmidi, that enables crystallization and biophysical characterization of CRBN-binding ligands and degraders.

Systemic sclerosis patients often develop cancer, but why this happens is poorly understood. Here, the authors propose a possible mechanism linking these diseases by showing increased somatic mutations and genome instability in systemic sclerosis.

Enzyme promiscuity seeds evolutionary innovation, but how flexible a single enzyme can be (re-)used during evolution remains unclear. Here, the authors show that various evolutionary trajectories applied to succinate semialdehyde dehydrogenase can compensate for the loss of two different functions in E. coli.

Pixel crosstalk can significantly reduce the image resolution in standard and super-resolution light microscopy using sCMOS cameras up to 28%. The effect for different imaging modalities was evaluated for several wavelengths and image sensor types.

Anlotinib hydrochloride is a multi-target tyrosine kinase receptor inhibitor, previously combined with anti-PD1 as therapeutic strategy for several cancer types. Here the authors report the results of a phase II trial of nivolumab (anti-PD1) plus anlotinib hydrochloride in patients with advanced gastric adenocarcinoma and esophageal squamous cell carcinoma.

Non-invasive approaches for risk stratification and screening remain crucial for colorectal cancer (CRC). Here, the authors develop a model for CRC risk stratification by integrating plasma proteomics data with polygenic risk score and QCancer-15 risk score, which could guide recommendations for earlier screening of high-risk populations.

Genetic and epidemiological investigations have yet to reveal what drives the large difference in ASD prevalence between the sexes. Here authors examine chromosome aneuploidy in a large ASD case-control cohort and report sex chromosome haploinsufficiency is a strong ASD risk factor, while the extra Y effect increases ASD risk significantly more than the extra X effect.

Type 1 diabetes (T1D) manifests as hyperglycemia, with spontaneous remission occasionally observed, but the underneath mechanisms are unclear. Here the authors analyses patients at different stages to find two populations of immune cells correlating with disease progression or remission, while results from mouse diabetes models validate these observations.

It is unclear whether providing the results of abdominal aortic calcification imaging to patients improves diet parameters. This randomized trial shows that this intervention does not lead to improvements in fruit and vegetable intake, while showing an effect on some cardiovascular disease risk factors used as secondary outcomes.

Six surveys show substantial public agreement with misinformation about wind farms. Agreement with diverse contrarian claims is best predicted by participants’ worldviews, most notably the tendency to believe conspiracy theories.

Plastic pollution can be dealt with advanced recycling and bio-based production. Best-case scenario would require 22 Mha of sugarcane areas in Brazil to meet the 2050 global biopolyethylene demand. However, this may require ecosystem trade-offs.

Unfairness in AI healthcare models arise from biased correlations between sensitive attributes and disease data. Here, the authors show that the Attribute Neutral Framework reduces these biases and enhances fairness without compromising diagnostic accuracy.

This paper proposes an open-source, impact-based forecast for tropical cyclone population displacement using both cyclone forecasts and population settlements and vulnerabilities. This is applied to Tropical Cyclone Yasa, striking Fiji in 2020.

The study shows that India’s agricultural subsidies have driven significant groundwater depletion by incentivizing overproduction of water-intensive crops like rice and wheat. This impact is evident in both Punjab’s alluvial aquifers and Madhya Pradesh’s hard rock aquifers.