Soft robots made of hydrogels with anisotropic and shape-change properties offer interesting design opportunities. Here, the authors report zwitterionic hydrogels and anisotropic cellulose nanocrystals composites in which the shear-induced alignment of cellulose nanocrystals allows for the development of shape-change programmable miniature robots.

Circularly polarized luminescence materials having simultaneously high dissymmetry factor and high luminescent quantum yield are desirable to improve applicability. Here, the authors report a soft photonic crystal film with chiral nanopores fulfilling these requirements when loaded with luminescent dyes.

The long-term stability of perovskite solar cells remains a critical challenge for the commercialization of the technology. Here, the authors adopt a non-noble metal/metal oxide/polymer multiple-barrier to suppress device degradation, achieving long-term stability in encapsulated p-i-n devices.

By combining graphene with transition metal dichalcogenides, such as WSe2, it is possible to induce a large spin-orbit interaction in the graphene layer. Here, Rao et al study the spin-orbit coupling in graphene/WSe2 heterostructures using the ballistic transport based technique, known transverse magnetic focusing.

The effect of various defects on α-phase stability of formamidinium lead triiodide perovskite remains unclear. Here, the authors reveal the degradation pathway, introduce water-insoluble compact layer to suppress α-phase collapse, and achieve maximum efficiency over 25% for perovskite solar cells.

Electric cooking and air-to-air heat pump adoption in China advances carbon neutrality and the rural energy transition, with the transformation costs offset by monetized health benefits in most provinces.

Crop intensification has increased agricultural production albeit with an increase in field antibiotic pollution. Here, Chen et al. project how antibiotic pollution undermines production and how intensification needs to be kept below a threshold.

Neman and Noy estimate the global climate change costs of extreme weather and find that US\(\$\) 143 B/yr of the costs of extreme events is attributable to climatic change. The majority of this is due to human loss of life.

Modelling a planktonic ecosystem in the ocean is challenging as it is embedded in a patch of water that is continuously moving, stretching, and diluting. This study introduces a new theoretical framework to account for such aspects, tracking a patch of water hosting a drifting ecosystem, along with its physical, environmental and biochemical features.

This work demonstrates how global abandoned cropland is an untapped land resource. If recultivated and reforested strategically, it can provide substantial carbon sequestration and food production potential to support our shared climate and food security goals.

The Bloom syndrome helicase (BLM) unwinds a variety of complex DNA structures including G quadruplex. Here the authors report RNF111-ARKL1-dependent ubiquitination of BLM in PML NBs, which limits BLM protein levels and maintains G quadruplex abundance in the nucleus.

How neural codes are passed from one brain area to the next remains poorly understood. Here, the authors show how neuronal feedback inhibition converts incoming temporal information into sparse rate information in a biophysical network model of the dentate gyrus.

Anaerobic methanotrophic archaea play crucial roles in the methane cycle. Here, Zhang et al. provide experimental evidence supporting that multi-heme cytochromes mediate extracellular electron transfer for the reduction of metals and electrodes in these microorganisms.

Mitochondrial DNA is known to exhibit heterogeneity of variants, even within a single cell. Here, the authors assessed this heteroplasmy of mitochondrial DNA within the UK Biobank cohort and showed that the presence of heteroplasmy and a functional score generated from heteroplasmic SNVs were associated with all-cause mortality and certain cancers.

Additional roles of metabolic enzymes in cancer remain to be explored. Here, the authors show nuclear localized PYCR1 undergoes IGF1R-mediated phosphorylation under hypoxia, binds with ELK4 and recruits SIRT7 to modulate transcription of target genes to promote colorectal cancer progression.

AI technology has the potential to substitute a human reader to aid services struggling to recruit staff or meet patient demand. Here, the authors show that the technology is a viable and potentially cost-effective strategy for use in the NHS.

Here, Wang et al. show that heat-inactivated Bifidobacterium adolescentis mediates maintenance of host intestinal barrier through intestinal stem cells activation, which can potentially have translational implications for alleviation of colon senescence and related diseases.

Omrani, Krepelova et al. report that aging-induced proinflammatory IFNγ/Stat1 signalling primes intestinal stem cells to a secretory fate and to antigen presenting cells impairing the regenerative capacity of the aging gut epithelium.

A coding variant of the PAX4 transcription factor (p.Arg192His) is uniquely associated with Type 2 Diabetes in East Asian populations. Here, the authors show that two different coding gene variants of PAX4, p.Arg192His and the newly identified p.Tyr186X, can influence pancreatic beta cell development, identity, and function.

Mitochondrial DNA is known to exhibit heterogeneity of variants, even within a single cell. Here, the authors assessed this heteroplasmy of mitochondrial DNA within the UK Biobank cohort and showed that the presence of heteroplasmy and a functional score generated from heteroplasmic SNVs were associated with all-cause mortality and certain cancers.

AI technology has the potential to substitute a human reader to aid services struggling to recruit staff or meet patient demand. Here, the authors show that the technology is a viable and potentially cost-effective strategy for use in the NHS.

In this Review article, the authors discuss emerging efforts to build ethical governance frameworks for data science health research in Africa and the opportunities to advance these through investments by African governments and institutions, international funding organizations and collaborations for research and capacity development.

Neman and Noy estimate the global climate change costs of extreme weather and find that US\(\$\) 143 B/yr of the costs of extreme events is attributable to climatic change. The majority of this is due to human loss of life.

Electric cooking and air-to-air heat pump adoption in China advances carbon neutrality and the rural energy transition, with the transformation costs offset by monetized health benefits in most provinces.

Crop intensification has increased agricultural production albeit with an increase in field antibiotic pollution. Here, Chen et al. project how antibiotic pollution undermines production and how intensification needs to be kept below a threshold.