The absence of catalytic asymmetric methods for synthesizing chiral (hetero)bicyclo[n.1.1]alkanes has hindered their application in new drug discovery. Herein the authors report an enantioselective formal (3 + 3) cycloaddition of bicyclobutanes with nitrones using a chiral Lewis acid catalyst for the synthesis of hetero-bicyclo[3.1.1]heptane.

Photocatalytic H₂O₂ synthesis is often performed in lab-scale batch reactors with low efficiency. Here, the authors report a biphasic fluid system that enables continuous H₂O₂ synthesis and automatic product extraction, addressing the limitations of traditional methods.

The authors introduce an extension of the popular fluorescence lifetime imaging microscopy (FLIM) named ixFLIM. By correlating the excitation spectrum with emission lifetime, ixFLIM can distinguish the fluorescent species in each pixel of the microscope image.

Distinguishing between different proteins that each bind to the same type of glycan is challenging. Here, the authors demonstrate that an enzymatically synthesised library of Lewis^x ‘glycofluoroforms’ that feature site-specific fluorination can discriminate closely related proteins.

NiPS₃, a van der Waals antiferromagnet exhibits exciton emission with a very sharp linewidth. The exact origin of this is has been a subject of active debate. Here, Wang et al study the behavior of this sharp exciton peak under applied magnetic fields, and find a Zeeman-like splitting, indicating the exciton has triplet-singlet character.

Atmospheric CO2 was  ~ 90 ppmv lower at the Last Glacial Maximum (LGM) than during the Holocene. Based on a carbon isotope budget, this study infers that at the LGM biological production pumped carbon into the deep ocean and sea ice kept it there.

Microbial carbon use efficiency (CUE) is crucial for carbon storage, but its variability is difficult to capture due to inconsistent measurements and complex interactions. This perspective proposes integrating diverse data and models to improve CUE in carbon cycle models

Despite high levels of trade, the basic characteristics of the aquatic food trade are largely unknown. Here, the authors present a global seafood trade database showing the increasing globalization of farmed and wild aquatic foods.

Active subsidence of the Konya region, Turkiye, is attributed to descent of a lithospheric drip into the mantle, according to analogue models, and suggests that major tectonic events may be linked to multistage dynamic flow processes in the mantle.

This study uses complex networks to identify atmospheric teleconnections driving summer heatwaves in the Northern Hemisphere. The results show that changes in certain teleconnections drive the spatial differences in heatwave variability and trends.

Elucidation of drought tolerance mechanism would help to develop tolerant crops. Here, the authors reveal the interaction between BBX18, a zinc finger transcription factor, and ascorbate peroxidase (APX1) to mediate drought stress resistance in tomato.

Upon stimulation of receptors, NAADP is formed as calcium-mobilizing second messenger in many cells. Here, the authors develop MASTER-NAADP, a membrane-permeant precursor of NAADP, and characterize its biological activity.

Here, the authors present 74 radiocarbon and 31 luminescence age determinations from four sites in southern Italy. They use these data to suggest that Neanderthal disappearance in the region predated the appearance of early modern humans, a previously unclear chronology

Biomolecular condensates are often composed of immiscible phases. Here, the authors reveal a functional biphasic organization of germ granules, where translational repression happens in the granule core and translation in the outer phase.

This study aims at enhancing hematopoietic stem cell (HSC) gene therapy potential to treat neurodegenerative diseases via innovative approaches. Findings demonstrate the therapeutic benefits of intracerebral transplantation of TREM2-engineered HSCs in an Alzheimer’s disease mouse model.

Normal maternal thyroid function holds significant relevance for pregnancy outcomes and long-term health. Here, the authors detect genetic associations with thyroid related traits in pregnant women.

Invasive cervical cancer is caused by HPV infection, but the disease itself is highly variable. Here, the authors use deep targeted sequencing to identify hotspot mutations in routine screening samples prior to diagnosis, which differed depending on HPV type.

Thrombosis and inflammation coexist in many diseases, however, there is lack of treatments targeting both pathologies. This study reports a novel antibody against blood factor XII, which bears a promise to treat broad thrombo-inflammatory disorder.

In vitro modelling of the adipose tissue-liver axis can advance understanding and therapy of metabolic disease, including by distinguishing effects of obesity and inflammation. Here, authors develop such a system based on isogenic human iPSCs and interconnected microphysiological devices.

The critical mediators responsible for cancer-associated cachexia development remain poorly defined. Here, the authors identify a distinct subset of neutrophil-like monocytes that facilitates progressive skeletal muscle wasting in cancer pathogenesis.

Despite high levels of trade, the basic characteristics of the aquatic food trade are largely unknown. Here, the authors present a global seafood trade database showing the increasing globalization of farmed and wild aquatic foods.

AI promises to transform medicine, but geographic concentration may hinder its equitable application. Here, authors map a global atlas of medical AI research and show that greater integration of global expertize could help AI deliver on its promise.

Rickman and colleagues explore scenarios for phasing out lending to fossil fuel firms. They analyse over $7 trillion of fossil fuel debt and show that financial regulation and international co-operation will be critical for a timely and just phase-out of fossil fuel finance.

Dissecting the associations between exposure to environmental pollution and cancer risk remains crucial. Here, the authors evaluate the impact of air and water pollution on cancer incidence in China using a spatial evaluation system and show that most excess cancer cases occurred in areas with the highest level of co-pollution.

This paper proposes storing hydrogen in pipes filled with gravel in lakes and reservoirs. Results show the levelized cost of hydrogen storage to be 0.17 USD kg−1 at 200 m depth, which is competitive with other hydrogen storage options.