NASA, ESA/Hubble (R. Fedriani et al)

Measuring the ionisation fraction in a jet from a massive protostar

Latest Research

Physical sciences

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  • Article
    | Open Access

    Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.

    • Richard H. Kimura
    • , Ling Wang
    • , Bin Shen
    • , Li Huo
    • , Willemieke Tummers
    • , Fabian V. Filipp
    • , Haiwei Henry Guo
    • , Thomas Haywood
    • , Lotfi Abou-Elkacem
    • , Lucia Baratto
    • , Frezghi Habte
    • , Rammohan Devulapally
    • , Timothy H. Witney
    • , Yan Cheng
    • , Suhas Tikole
    • , Subhendu Chakraborti
    • , Jay Nix
    • , Christopher A. Bonagura
    • , Negin Hatami
    • , Joshua J. Mooney
    • , Tushar Desai
    • , Scott Turner
    • , Richard S. Gaster
    • , Andrea Otte
    • , Brendan C. Visser
    • , George A. Poultsides
    • , Jeffrey Norton
    • , Walter Park
    • , Mark Stolowitz
    • , Kenneth Lau
    • , Eric Yang
    • , Arutselvan Natarajan
    • , Ohad Ilovich
    • , Shyam Srinivas
    • , Ananth Srinivasan
    • , Ramasamy Paulmurugan
    • , Juergen Willmann
    • , Frederick T. Chin
    • , Zhen Cheng
    • , Andrei Iagaru
    • , Fang Li
    •  & Sanjiv S. Gambhir
  • Article
    | Open Access

    Chorus waves are crucial on radiation belt dynamics in the space of magnetized planets. Here, the authors show that initially excited single-band chorus waves can quickly accelerate medium energy electrons, and divide the anisotropic electrons into low and high energy components, which subsequently excite two-band chorus waves.

    • Jinxing Li
    • , Jacob Bortnik
    • , Xin An
    • , Wen Li
    • , Vassilis Angelopoulos
    • , Richard M. Thorne
    • , Christopher T. Russell
    • , Binbin Ni
    • , Xiaochen Shen
    • , William S. Kurth
    • , George B. Hospodarsky
    • , David P. Hartley
    • , Herbert O. Funsten
    • , Harlan E. Spence
    •  & Daniel N. Baker
  • Article
    | Open Access

    Synthetic gene oscillators can be used to control timed function and periodic expression of genes. Here the authors demonstrate in vivo implementation in the mammalian gut that can keep time over several days.

    • David T. Riglar
    • , David L. Richmond
    • , Laurent Potvin-Trottier
    • , Andrew A. Verdegaal
    • , Alexander D. Naydich
    • , Somenath Bakshi
    • , Emanuele Leoncini
    • , Lorena G. Lyon
    • , Johan Paulsson
    •  & Pamela A. Silver

Earth and environmental sciences

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  • Article
    | Open Access

    The marginal interaction zones of oceans are understudied. Here, the authors analyse seismic observations of temporal changes at the interface between thermocline layers in the Panama Basin, that reveal a critical mixing state in which turbulent diffusion is gradually replaced by double-diffusion as the dominant mixing process.

    • Qunshu Tang
    • , Vincent C. H. Tong
    • , Richard W. Hobbs
    •  & Miguel Ángel Morales Maqueda
  • Article
    | Open Access

    Chorus waves are crucial on radiation belt dynamics in the space of magnetized planets. Here, the authors show that initially excited single-band chorus waves can quickly accelerate medium energy electrons, and divide the anisotropic electrons into low and high energy components, which subsequently excite two-band chorus waves.

    • Jinxing Li
    • , Jacob Bortnik
    • , Xin An
    • , Wen Li
    • , Vassilis Angelopoulos
    • , Richard M. Thorne
    • , Christopher T. Russell
    • , Binbin Ni
    • , Xiaochen Shen
    • , William S. Kurth
    • , George B. Hospodarsky
    • , David P. Hartley
    • , Herbert O. Funsten
    • , Harlan E. Spence
    •  & Daniel N. Baker
  • Article
    | Open Access

    The defaunation of vertebrates may disrupt forest functioning through the loss of plant-animal interactions, but impacts on forests remain unquantified. Here the authors show that seed dispersal is a key interaction and defaunation of primates and birds negatively impacts forest regeneration.

    • Charlie J. Gardner
    • , Jake E. Bicknell
    • , William Baldwin-Cantello
    • , Matthew J. Struebig
    •  & Zoe G. Davies

Biological sciences

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  • Article
    | Open Access

    Optimisation of nucleic acid probes and blocker strands can be laborious. Here the authors construct a theoretical model of competitive DNA hybridisation to design DNA probes for optimisation-free mutation detection.

    • Xin Chen
    • , Na Liu
    • , Liquan Liu
    • , Wei Chen
    • , Na Chen
    • , Meng Lin
    • , Jiaju Xu
    • , Xing Zhou
    • , Hongbo Wang
    • , Meiping Zhao
    •  & Xianjin Xiao
  • Article
    | Open Access

    Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.

    • Nicolas Mercado
    • , Gabi Schutzius
    • , Christian Kolter
    • , David Estoppey
    • , Sebastian Bergling
    • , Guglielmo Roma
    • , Caroline Gubser Keller
    • , Florian Nigsch
    • , Adrian Salathe
    • , Remi Terranova
    • , John Reece-Hoyes
    • , John Alford
    • , Carsten Russ
    • , Judith Knehr
    • , Dominic Hoepfner
    • , Alexandra Aebi
    • , Heinz Ruffner
    • , Tanner C. Beck
    • , Sajjeev Jagannathan
    • , Calla M. Olson
    • , Hadley E. Sheppard
    • , Selma Z. Elsarrag
    • , Tewis Bouwmeester
    • , Mathias Frederiksen
    • , Felix Lohmann
    • , Charles Y. Lin
    •  & Susan Kirkland
  • Article
    | Open Access

    Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.

    • Richard H. Kimura
    • , Ling Wang
    • , Bin Shen
    • , Li Huo
    • , Willemieke Tummers
    • , Fabian V. Filipp
    • , Haiwei Henry Guo
    • , Thomas Haywood
    • , Lotfi Abou-Elkacem
    • , Lucia Baratto
    • , Frezghi Habte
    • , Rammohan Devulapally
    • , Timothy H. Witney
    • , Yan Cheng
    • , Suhas Tikole
    • , Subhendu Chakraborti
    • , Jay Nix
    • , Christopher A. Bonagura
    • , Negin Hatami
    • , Joshua J. Mooney
    • , Tushar Desai
    • , Scott Turner
    • , Richard S. Gaster
    • , Andrea Otte
    • , Brendan C. Visser
    • , George A. Poultsides
    • , Jeffrey Norton
    • , Walter Park
    • , Mark Stolowitz
    • , Kenneth Lau
    • , Eric Yang
    • , Arutselvan Natarajan
    • , Ohad Ilovich
    • , Shyam Srinivas
    • , Ananth Srinivasan
    • , Ramasamy Paulmurugan
    • , Juergen Willmann
    • , Frederick T. Chin
    • , Zhen Cheng
    • , Andrei Iagaru
    • , Fang Li
    •  & Sanjiv S. Gambhir

Health sciences

See All
  • Article
    | Open Access

    Knottin is a cystine knot peptide. Here, the authors develop a knottin-based tracer for positron emission tomography and demonstrate its ability to detect cancer and idiopathic pulmonary fibrosis through selective binding to integrin αvβ6.

    • Richard H. Kimura
    • , Ling Wang
    • , Bin Shen
    • , Li Huo
    • , Willemieke Tummers
    • , Fabian V. Filipp
    • , Haiwei Henry Guo
    • , Thomas Haywood
    • , Lotfi Abou-Elkacem
    • , Lucia Baratto
    • , Frezghi Habte
    • , Rammohan Devulapally
    • , Timothy H. Witney
    • , Yan Cheng
    • , Suhas Tikole
    • , Subhendu Chakraborti
    • , Jay Nix
    • , Christopher A. Bonagura
    • , Negin Hatami
    • , Joshua J. Mooney
    • , Tushar Desai
    • , Scott Turner
    • , Richard S. Gaster
    • , Andrea Otte
    • , Brendan C. Visser
    • , George A. Poultsides
    • , Jeffrey Norton
    • , Walter Park
    • , Mark Stolowitz
    • , Kenneth Lau
    • , Eric Yang
    • , Arutselvan Natarajan
    • , Ohad Ilovich
    • , Shyam Srinivas
    • , Ananth Srinivasan
    • , Ramasamy Paulmurugan
    • , Juergen Willmann
    • , Frederick T. Chin
    • , Zhen Cheng
    • , Andrei Iagaru
    • , Fang Li
    •  & Sanjiv S. Gambhir
  • Article
    | Open Access

    The Chlamydia pneumoniae adhesin LIPP plays a role in host cell entry and infection. Here, the authors find that LIPP binds to the host plasma membrane and mediates phosphatidylserine translocation, enhancing pathogen internalization without induction of apoptosis.

    • Jan N. Galle
    • , Tim Fechtner
    • , Thorsten Eierhoff
    • , Winfried Römer
    •  & Johannes H. Hegemann
  • Article
    | Open Access

    Retrotransposition events have been linked to some human disorders. Here, Gardner et al. systematically search for mobile genetic elements (ME) in trio whole exome-sequencing datasets and ascertain 9 de novo MEs and further estimate genome-wide germline ME burden and constraint.

    • Eugene J. Gardner
    • , Elena Prigmore
    • , Giuseppe Gallone
    • , Petr Danecek
    • , Kaitlin E. Samocha
    • , Juliet Handsaker
    • , Sebastian S. Gerety
    • , Holly Ironfield
    • , Patrick J. Short
    • , Alejandro Sifrim
    • , Tarjinder Singh
    • , Kate E. Chandler
    • , Emma Clement
    • , Katherine L. Lachlan
    • , Katrina Prescott
    • , Elisabeth Rosser
    • , David R. FitzPatrick
    • , Helen V. Firth
    •  & Matthew E. Hurles

News & Comment

  • Comment
    | Open Access

    Plastic pollution is a purely anthropogenic problem and cannot be solved without large-scale human action. Motivating mitigation actions requires more realistic assumptions about human decision-making based on empirical evidence from the behavioural sciences enabling the design of more effective interventions.

    • Lili Jia
    • , Steve Evans
    •  & Sander van der Linden
  • Comment
    | Open Access

    Understanding complex functional materials suffers from needing to capture structural features on many length scales. By quantitatively combining complementary experimental measurements, realistic models can now be generated. Here, I discuss the strengths and limits of this approach, but also advocate focusing on the interactions that drive structural complexity instead.

    • Andrew L. Goodwin
  • Editorial
    | Open Access

    Originally designed for measuring isotope abundances and elemental masses, mass spectrometry is becoming a mainstay across life sciences. As electrospray ionization of biomolecules turns 30 and the Orbitrap mass analyzer 20, we take this opportunity to highlight the role of both inventions in stirring mass spectrometry from physics into biology and discuss the advances and challenges that may impact the future applications of biomolecular mass spectrometry.

  • Comment
    | Open Access

    John Fenn’s electrospray mass spectrometry (ESMS) was awarded the chemistry Nobel Prize in 2002 and is now the basis of the entire field of MS-based proteomics. Technological progress continues unabated, enabling single cell sensitivity and clinical applications.

    • Matthias Mann
  • Comment
    | Open Access

    The establishment of the Orbitrap analyzer as a major player in mass spectrometry based proteomics is traced back to the first public presentation of this technology 20 years ago; when a proof-of-principle application led the way to further advancements and biological applications.

    • Alexander Makarov
  • Comment
    | Open Access

    The health of the city depends on how well all the elements of this system are interconnected and operating in harmony. Here the authors introduced the concept of urbanome which is analogous to the human genome that can be used to characterise the form and functioning of cities.

    • Lidia Morawska
    • , Wendy Miller
    • , Matt Riley
    • , Sotiris Vardoulakis
    • , Yong-Guan Zhu
    • , Guy B. Marks
    • , Prachi Garnawat
    • , Prashant Kumar
    •  & Marie Thynell

Focus

Organic Chemistry and Chemical Biology

SEBASTIAN KAULITZKI/SCIENCE PHOTO LIBRARY/Getty

Organic Chemistry and Chemical Biology

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Giovanni Bottari, Julia Eckhoff, Johannes Kreutzer and Prabhjot Saini

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