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Microengineered 3D motors powered by bacteria and driven by light

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  • Article | | open

    Wiskott-Aldrich syndrome protein (WASp) is essential for controlling the cytoskeleton, but its function in innate immunity is unclear. Here the authors show that WASp deficiency is associated with dysregulated septin cage formation, excessive inflammasome activation, elevated immune cell death and reduced bacterial clearance.

    • Pamela P. Lee
    • , Damián Lobato-Márquez
    • , Nayani Pramanik
    • , Andrea Sirianni
    • , Vanessa Daza-Cajigal
    • , Elizabeth Rivers
    • , Alessia Cavazza
    • , Gerben Bouma
    • , Dale Moulding
    • , Kjell Hultenby
    • , Lisa S. Westerberg
    • , Michael Hollinshead
    • , Yu-Lung Lau
    • , Siobhan O. Burns
    • , Serge Mostowy
    • , Mona Bajaj-Elliott
    •  & Adrian J. Thrasher
  • Article | | open

    The source of the Transantarctic Mountains’ high elevation has remained unclear. Here, the authors present data from a 550 km long magnetotelluric geophysical transect showing that uplift is likely to be mechanical via cantilevered flexure along a master boundary fault and not upper mantle or lower crustal thermal mechanisms.

    • Phil Wannamaker
    • , Graham Hill
    • , John Stodt
    • , Virginie Maris
    • , Yasuo Ogawa
    • , Kate Selway
    • , Goran Boren
    • , Edward Bertrand
    • , Daniel Uhlmann
    • , Bridget Ayling
    • , A. Marie Green
    •  & Daniel Feucht
  • Article | | open

    Neutralizing antibodies to oligomannose glycans on HIV Env are difficult to elicit, possibly due to B cell tolerance. Here, Pantophlet et al. synthesize mimetics based on a bacterial oligosaccharide and show that they evoke HIV-neutralizing antibody responses in animals with a human Ig repertoire.

    • Ralph Pantophlet
    • , Nino Trattnig
    • , Sasha Murrell
    • , Naiomi Lu
    • , Dennis Chau
    • , Caitlin Rempel
    • , Ian A. Wilson
    •  & Paul Kosma
  • Article | | open

    Lysosomal distribution is linked to the role of lysosomes in many cellular functions. Here the authors show that the lysosomal protein TMEM55B is regulated by TFEB and recruits JIP4 to the lysosomal surface inducing dynein-dependent transport of lysosomes toward the cell center in response to stress conditions.

    • Rose Willett
    • , José A. Martina
    • , James P. Zewe
    • , Rachel Wills
    • , Gerald R. V. Hammond
    •  & Rosa Puertollano
  • Article | | open

    Leishmaniasis is a parasitic disease transmitted by the bite of infected sand flies. Here the authors describe an atomic resolution cryo-EM structure of the Leishmania ribosome in complex with the recently approved drug paromomycin (PAR) and highlight conserved elements in the drug binding pocket that mediate PAR deleterious effects on the parasite.

    • Moran Shalev-Benami
    • , Yan Zhang
    • , Haim Rozenberg
    • , Yuko Nobe
    • , Masato Taoka
    • , Donna Matzov
    • , Ella Zimmerman
    • , Anat Bashan
    • , Toshiaki Isobe
    • , Charles L. Jaffe
    • , Ada Yonath
    •  & Georgios Skiniotis

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