Dynamic Jahn-Teller effect is rarely realized in condensed matter systems. Here, the authors demonstrate its occurrence in Ba₂MgReO₆, a 5d¹ double perovskite, using resonant inelastic x-ray scattering, thermodynamic measurements and quantum chemistry calculations.

Cancer immunotherapy leans on the effective activation on immune response within tumors and surrounding immunosuppressive microenvironment. Here, the authors report a triblock copolymeric nanocarrier encapsulating Resiquimod for B16F10 cell-targeting, which enables in situ tumor vaccination and tumor-associated macrophages polarization.

In the arena of strained heterocyclic chemistry, phosphacycles as appealing electrophilic P-containing building blocks are underestimated. Here, the authors report a class of electrophilic phosphiranium salts bearing fluorinated benzyl quaternizing groups for the direct synthesis of diverselyβ-functionalized phosphines.

Boron-doped acenes have attracted attention due to their unique structures and luminescent properties but the hitherto known boron-doped acenes have only one or two boron atoms, limiting the chemical space of this family of compounds. Here, the authors demonstrate the synthesis of quadruply boron-doped acenes, including pentacene, heptacene, and nonacene.

In this work, authors present an integral MCNP model of the ITER facility for radiation transport, addressing limitations of separate models for the Tokamak and Tokamak Complex. This model streamlines safety simulations, enhancing the robustness and simplicity of radiation safety analysis.

Combining laser-driven shock compression and ultra-short X-ray pulses from LCLS, the local structure of liquid silicates was determined up to 385 GPa. Compared with molecular dynamics calculations, continuous densification of O-O and Mg-Si networks may alter melt properties and impact planetary differentiation.

Here, the authors show that germ cell transplantation and surrogate production of bluefin tuna sperm in small-bodied fish species shortens the period in which sperm is produced. This study opens the possibility of highly efficient seed production in bluefin tuna.

The study examines how land property rights impact land use efficiency (LUE) globally, based on the SDG 11.3.1 indicator. Secure rights improve LUE, with common law countries outperforming civil law countries, supporting sustainable land management.

A presented regression-based approach to the CO₂ airborne fraction is statistically superior to the conventional ratio-based approach. It reduces estimation uncertainty, requires fewer assumptions, and treats future scenarios with zero emissions.

This analysis of net-zero strategies designed in an iterative stakeholder dialogue finds that without behavioral change and with restriction of technologies, the target of greenhouse gas neutrality in the European Union cannot be reached.

Chronic pain remains a major clinical challenge with unclear causes and a need for new treatment. Using the single-cell transcriptomics atlas iPain, here the authors show that nociceptor senescence may drive chronic pain and present senolytics as a potential therapeutic approach.

Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous and aggressive type of T-cell lymphoma. Here, the authors perform single-cell analyses of human and murine PTCL-NOS tumors, and identify a subtype defined by the loss of SMARCB1 that could be targeted with HDAC-inhibitor combination therapies.

Using a biofilm evolution assay, this study improves the antimicrobial and antibiofilm efficacy of Pseudomonas aeruginosa bacteriophages, while a two-phage cocktail shows further improved antimicrobial efficacy without incurring dual-bacteriophage-resistance.

Black widow spider venom contains seven structurally related toxins acting at presynaptic nerve terminals. Here, the authors provide cryo-EM structures of vertebrate-specific αLTX in two states and decipher how the toxin forms cation-selective pores.

Plant survival under low K⁺ relies on the function of the K⁺ transporter HAK5. Here, the authors show the transport characteristics of Arabidopsis HAK5, unveiling its K⁺ and pH dependent activation and deactivation kinetics.

Cancer immunotherapy leans on the effective activation on immune response within tumors and surrounding immunosuppressive microenvironment. Here, the authors report a triblock copolymeric nanocarrier encapsulating Resiquimod for B16F10 cell-targeting, which enables in situ tumor vaccination and tumor-associated macrophages polarization.

Chronic pain remains a major clinical challenge with unclear causes and a need for new treatment. Using the single-cell transcriptomics atlas iPain, here the authors show that nociceptor senescence may drive chronic pain and present senolytics as a potential therapeutic approach.

Marginal liver grafts are associated with a higher risk of graft failure due to their increased susceptibility to ischemia-reperfusion injury. Here, the authors show the regulatory mechanism of fibroblast growth factor 21 and offer insights into its clinical application in early liver graft injury.

Current CRISPR diagnostic approaches can be hampered by several limitations, including low signal transduction efficiency and limited sensitivity. Here, the authors present CrisprAIE, an approach based on CRISPR/Cas-mediated “one to more” lighting-up nucleic acid detection using aggregation-induced emission luminogens.

The SARS-CoV-2 JN.1 lineage spread rapidly in winter 2023-24 with high estimated levels of transmission but limited increase in severe disease burden. Here, the authors use electronic health record data from the United States to investigate the immune history and clinical outcomes of patients infected with this strain.

In this work, authors present an integral MCNP model of the ITER facility for radiation transport, addressing limitations of separate models for the Tokamak and Tokamak Complex. This model streamlines safety simulations, enhancing the robustness and simplicity of radiation safety analysis.

The study examines how land property rights impact land use efficiency (LUE) globally, based on the SDG 11.3.1 indicator. Secure rights improve LUE, with common law countries outperforming civil law countries, supporting sustainable land management.

Why people like and share content on social media is poorly understood. Here, the authors investigate social media engagement with posts mentioning identity and expressing ingroup solidarity and outgroup hostility before and after the 2022 Russian invasion of Ukraine.

Memories of our past experiences enable us to reconstruct (in the present) our past better than our future. Here, the authors show that we are also able to better reconstruct the pasts (versus futures) in other people’s lives.