Xudong Lin, Xin Duan et al.

High-throughput brain activity mapping for systems neuropharmacology

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Physical sciences

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  • Article | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Article | | open

    Particulate organic carbon (POC) fluxes in the oceans, particularly the Southern Ocean, remain poorly constrained. Here the authors modelled the potential underestimated flux of POC originating from Antarctic krill and discovered a seasonal krill faecal pellet export flux of 0.039 GT C yr-1 across the marginal ice zone (MIZ) of the Southern Ocean.

    • A. Belcher
    • , S. A. Henson
    • , C. Manno
    • , S. L. Hill
    • , A. Atkinson
    • , S. E. Thorpe
    • , P. Fretwell
    • , L. Ireland
    •  & G. A. Tarling
  • Article | | open

    Thermoelectric clathrates host guest atoms that can rattle inside their surrounding cages, yielding unusual phononic properties. Ikeda et al. show that ab initio calculations fail to account for thermodynamic and thermal transport data and propose a Kondo-like mechanism to explain the discrepancy.

    • M. S. Ikeda
    • , H. Euchner
    • , X. Yan
    • , P. Tomeš
    • , A. Prokofiev
    • , L. Prochaska
    • , G. Lientschnig
    • , R. Svagera
    • , S. Hartmann
    • , E. Gati
    • , M. Lang
    •  & S. Paschen

Earth and environmental sciences

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Biological sciences

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  • Article | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Article | | open

    Particulate organic carbon (POC) fluxes in the oceans, particularly the Southern Ocean, remain poorly constrained. Here the authors modelled the potential underestimated flux of POC originating from Antarctic krill and discovered a seasonal krill faecal pellet export flux of 0.039 GT C yr-1 across the marginal ice zone (MIZ) of the Southern Ocean.

    • A. Belcher
    • , S. A. Henson
    • , C. Manno
    • , S. L. Hill
    • , A. Atkinson
    • , S. E. Thorpe
    • , P. Fretwell
    • , L. Ireland
    •  & G. A. Tarling
  • Article | | open

    The pluripotency factor SHOOTMERISTEMLESS (STM) maintains stem cell identity in the centre of the shoot apical meristem. Here Chung et al. show that Auxin Response Factors work in concert with the YABBY transcription factor FIL to silence STM via chromatin modifications and allow initiation of primordia that lead to formation of flowers.

    • Yuhee Chung
    • , Yang Zhu
    • , Miin-Feng Wu
    • , Sara Simonini
    • , Andre Kuhn
    • , Alma Armenta-Medina
    • , Run Jin
    • , Lars Østergaard
    • , C. Stewart Gillmor
    •  & Doris Wagner

Health sciences

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  • Article | | open

    Anti-human leukocyte antigen (HLA) antibodies are important mediators of alloresponses, but structural insights on antibody:HLA interaction are still lacking. Here the authors provide a 2.4 Å structure of antibody:HLA complex, and also analyse HLA features important for other HLA-interacting molecules, to enhance our understanding of alloimmunity.

    • Yue Gu
    • , Yee Hwa Wong
    • , Chong Wai Liew
    • , Conrad E. Z. Chan
    • , Tanusya M. Murali
    • , Jiawei Yap
    • , Chien Tei Too
    • , Kiren Purushotorman
    • , Maryam Hamidinia
    • , Abbas El Sahili
    • , Angeline T. H. Goh
    • , Rachel Z. C. Teo
    • , Kathryn J. Wood
    • , Brendon J. Hanson
    • , Nicholas R. J. Gascoigne
    • , Julien Lescar
    • , Anantharaman Vathsala
    •  & Paul A. MacAry
  • Article | | open

    Bioconjugation is a promising process to manufacture conjugate vaccines, but currently employed enzymes cannot generate the full spectrum of bacterial glycoproteins. Here, the authors use an O-linking oligosaccharyltransferase to generate a polyvalent pneumococcal bioconjugate vaccine with polysaccharides containing glucose at their reducing end.

    • Christian M. Harding
    • , Mohamed A. Nasr
    • , Nichollas E. Scott
    • , Guillaume Goyette-Desjardins
    • , Harald Nothaft
    • , Anne E. Mayer
    • , Sthefany M. Chavez
    • , Jeremy P. Huynh
    • , Rachel L. Kinsella
    • , Christine M. Szymanski
    • , Christina L. Stallings
    • , Mariela Segura
    •  & Mario F. Feldman
  • Article | | open

    Orthobunyaviruses (OBVs) cause severe disease in humans and farm animals, but the molecular basis for infection is not fully understood. Here, the authors present crystal structures of free and antibody-bound OBV envelope glycoproteins and show that their domains enable efficient immunization in a mouse model.

    • Jan Hellert
    • , Andrea Aebischer
    • , Kerstin Wernike
    • , Ahmed Haouz
    • , Emiliana Brocchi
    • , Sven Reiche
    • , Pablo Guardado-Calvo
    • , Martin Beer
    •  & Félix A. Rey

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Inorganic and Physical Chemistry

M. Eugenio Vázquez-Sentís/doi:10.1038/s41467-018-05183-8

Inorganic and Physical Chemistry

Editors' Highlights: Each month our editors select a small number of Articles recently published in Nature Communications that they believe are particularly interesting or important.

Long Chen, Victoria Richards, Ariane Vartanian and Adam West

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