Microscopic image of parasites in lung tissue

Impact of pulmonary African trypanosomes on the immunology and function of the lung

Sleeping sickness is a disease caused by Trypanosoma parasites. Mabille et al. study how the parasites (colourized in the image) affect respiratory function and lung immune responses.


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Latest Research articles

  • Desorption of ions from sorbents generally involves high acid or base concentrations and long desorption times, especially for multivalent ions. Here the authors report a rapid and efficient desorption of Co2+, Mn2+, and Sr2+ adsorbed on magnetite-graphene oxide that occurs by adding low amounts of Al3+, which is shown to interact with graphene more strongly than divalent ions.

    • Xinming Xia
    • Feng Zhou
    • Haiping Fang
    Article Open Access
  • Spin simulators can solve many combinatorial optimization problems that can be represented by spin models, but they are limited to low-dimensional spins. Here the authors propose a simulator of multidimensional spins in arbitrary dimension, using a system of coupled parametric oscillators with a common pump.

    • Marcello Calvanese Strinati
    • Claudio Conti
    Article Open Access

Subjects within Physical sciences

Subjects within Earth and environmental sciences

Subjects within Biological sciences

  • Studying the cell composition of acral melanoma at the single-cell level could provide some clues about its poor response to immunotherapy. Here, the authors analyse acral and cutaneous melanoma patient samples using single-cell RNA-sequencing, and reveal a severe immunosuppressive state in acral melanomas

    • Chao Zhang
    • Hongru Shen
    • Jilong Yang
    Article Open Access
  • Drug induced liver injury (DILI) is an important cause acute liver failure. Here the authors report that serum Mg2+ serum levels decrease in patients with DILI as well as in preclinical animal models treated with acetaminophen overdose, and that early intervention targeting the Mg2+ transporter Cyclin M4 may be beneficial for acetaminophen overdose in preclinical models.

    • Irene González-Recio
    • Jorge Simón
    • Maria L Martínez-Chantar
    Article Open Access
  • The interferon response has been shown to be linked to severity of SARS-CoV-2 infection and is an essential component of the immune response to COVID-19. Here the authors stratify patients according to COVID-19 severity and asses the interferon response showing defective responses in severe infection and highlight the importance of assay variables and confounding factors that impact the detection of interferon.

    • Nikaïa Smith
    • Céline Possémé
    • Darragh Duffy
    Article Open Access
  • Adipose tissue is an important secretory organ, but less is known about the secretory activity of perivascular fat. Here the authors use proteomics analysis on secretomes from perivascular fat to identify neuronal growth regulator 1 as an adipocyte-derived neurotrophic factor, whose decreased secretion in obesity results in a loss of sympathetic innervation of adipose depots in mice.

    • Elisa Duregotti
    • Christina M. Reumiller
    • Manuel Mayr
    Article Open Access

Subjects within Health sciences

  • Misinformation online can be shared by major political figures and organizations. Here, the authors developed a method to measure exposure to information from these sources on Twitter, and show how exposure relates to the quality of the content people share and their political ideology.

    • Mohsen Mosleh
    • David G. Rand
    Article Open Access
  • The COVID-19 pandemic has stimulated an important changes in online information access. Here, the authors analyse everyday web search interactions across 25,150 US ZIP codes revealing significant differences in how digital informational resources are mobilized by different communities.

    • Jina Suh
    • Eric Horvitz
    • Tim Althoff
    Article Open Access
  • Systemic risk and bank bailout approaches have been the source of discussions on scientific, financial and governmental forums. An artificial intelligence technique is proposed to inform equitable bailout decisions that minimise taxpayers’ losses.

    • Daniele Petrone
    • Neofytos Rodosthenous
    • Vito Latora
    Article Open Access
  • In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.

    • Anderson F. Brito
    • Elizaveta Semenova
    • Nuno R. Faria
    Article Open Access

Subjects within Scientific community and society

  • Rivers and streams are increasingly drying with climate change and biogeochemical impacts may be important. In this comment the authors discuss the challenges to the biogeochemistry of non-perennial rivers and streams, and what can be done to tackle them.

    • Margaret A. Zimmer
    • Amy J. Burgin
    • Jacob Hosen
    Comment Open Access
  • Financing of urban greening has traditionally prioritized economic growth. Here the authors argue for action to ensure more socially just green financing.

    • Melissa García-Lamarca
    • Isabelle Anguelovski
    • Kayin Venner
    Comment Open Access
  • Very few of the COVID-19 ML models were fit for deployment in real-world settings. In this Comment, Huang et al. discuss the main steps required to develop clinically useful models in the context of an emerging infectious disease.

    • Shih-Cheng Huang
    • Akshay S. Chaudhari
    • Matthew P. Lungren
    Comment Open Access
  • Rigorous, robust replication and generalization studies present a significant investment into the quality of the research record, the foundation on which new research is built. Communications Psychology and the Human Behaviour Team at Nature Communications are inviting submissions of replication studies in psychology and the human behavioural sciences.

    Editorial Open Access
  • The colonial practices of geoscience have created long term vulnerabilities to natural hazards. In this comment the ongoing consequence are explored of colonialism as well as the actions that are needed to be taken to reduce natural hazard risk.

    • Jazmin P. Scarlett
    Comment Open Access
  • The authors provide a metrology-led perspective on best practice for the electrochemical characterisation of materials for electrochemical energy technologies. Such electrochemical experiments are highly sensitive, and their results are, in practice, often of uncertain quality and challenging to reproduce quantitatively.

    • Graham Smith
    • Edmund J. F. Dickinson
    Comment Open Access

Ecology and evolution

This page includes topics like the evolution of genes, molecules, lineages, populations, societies and languages; palaeontology, archaeology and anthropology, coevolution, behavioural ecology, ecosystem and community ecology, biogeography and macroecology, conservation biology, agroecology, disease ecology and zoology.


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