Microscopic image of parasites in lung tissue

Impact of pulmonary African trypanosomes on the immunology and function of the lung

Sleeping sickness is a disease caused by Trypanosoma parasites. Mabille et al. study how the parasites (colourized in the image) affect respiratory function and lung immune responses.

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Latest Research articles

  • Lattice anchoring, in its varied forms, has proven effective at regulating the energetics of metastable phases of polymorphic crystals. Here, the authors utilize top-down photolithography to embed a tessellating 3D interfacial network into otherwise-unstable CsPbI3 perovskite thin films and devices, stabilizing the perovskite phase.

    • Julian A. Steele
    • Tom Braeckevelt
    • Maarten B. J. Roeffaers
    Article Open Access
  • Liquid water is key for life as we know it. Here, the authors show even with a modest geothermal heat flow, subglacial oceans of liquid water can form at the base of and within the ice sheets on exo-Earths, which may provide habitable conditions for an extended period.

    • Lujendra Ojha
    • Bryce Troncone
    • George McDonald
    Article Open Access
  • Artificial Intelligence has achieved success in a variety of single-player or competitive two-player games with no communication between players. Here, the authors propose an approach where Artificial Intelligence agents have ability to negotiate and form agreements, playing the board game Diplomacy.

    • János Kramár
    • Tom Eccles
    • Yoram Bachrach
    Article Open Access

Subjects within Physical sciences

  • The impact of three extinction events during the Permo–Triassic interval on terrestrial invertebrates is unclear. Here, the authors find that key abiotic and biotic factors, including changes in floral assemblages, were correlated with changes in insect diversity through this interval.

    • Corentin Jouault
    • André Nel
    • Fabien L. Condamine
    Article Open Access
  • External ecological interactions and intrinsic biological parameters affect evolutionary pathways and animal diversity. Here, the authors use ruminant inner ear morphology to investigate patterns of diversity through 33 million years, finding clade-dependent climate and paleogeographic trends.

    • Bastien Mennecart
    • Laura Dziomber
    • Loïc Costeur
    Article Open Access
  • Our understanding of microbial diversity and physiology in marine sediments is limited. Here, Gong et al. analyze thousands of metagenome-assembled genomes (MAGs) from coastal and deep-sea sediments, and identify MAGs belonging to new bacterial phyla that seem able to mediate key steps in sedimentary biogeochemistry.

    • Xianzhe Gong
    • Álvaro Rodríguez del Río
    • Brett J. Baker
    Article Open Access

Subjects within Earth and environmental sciences

Subjects within Biological sciences

  • In this disease mapping study, the authors estimate disability-adjusted life year rates for three of the major causes of mortality for children under five 43 countries in sub-Saharan Africa. They identify significant heterogeneity at the subnational level, highlighting the need for a targeted intervention approach.

    • Robert C. Reiner Jr.
    • Catherine A. Welgan
    • Simon I. Hay
    Article Open Access
  • Vascular smooth muscle cells (VSMCs) are known for their fate plasticity in atherosclerosis plaque progression. Here, Zhai et al. show that extracellular traps generated from CD68 + VSMCs adversely contribute to plaque progression and highlight their unexpected role in plaque stability by regulating the direction of VSMC trans-differentiation.

    • Ming Zhai
    • Shiyu Gong
    • Wenhui Peng
    Article Open Access
  • Gpr174 is a regulator of regulatory T cells, which play an important role in angiogenesis after hindlimb ischemia. Here, the authors show GPR174-deficient Tregs promote AREG expression by inhibiting Gαs/cAMP/PKA signal pathway and increasing EGR1 nuclear accumulation to improve angiogenesis and vascular remodeling in response to ischemic injury.

    • Jin Liu
    • Lihong Pan
    • Aijun Sun
    Article Open Access
  • The identification of distinct cell populations with cellular plasticity in skin basal cell carcinoma is important for understanding treatment resistance mechanisms. Here, the authors identify the resistant LY6D+ basosquamous population that correlates with poor clinical outcomes.

    • Daniel Haensel
    • Sadhana Gaddam
    • Anthony E. Oro
    Article Open Access
  • Hyperactivation of the toll-like receptors (TLRs) have been implicated as risk factors for more severe forms of disease in COVID-19 and metabolic (dysfunction) associated fatty liver disease (MAFLD). Here the authors report that MBOAT7 is reduced in macrophages of patients with MAFLD and COVID-19, and acts as a negative regulator of TLR signalling.

    • Jawaher Alharthi
    • Ali Bayoumi
    • Mohammed Eslam
    Article Open Access

Subjects within Health sciences

  • Here, by studying a multi-ethnic cross-sectional urban cohort (N = 3211, 6 ethnic groups), the authors show that depressive symptom levels are related to the gut microbiota taxonomic characteristics but that these are largely invariant across ethnic groups.

    • Jos A. Bosch
    • Max Nieuwdorp
    • Anja Lok
    Article Open Access
  • Since the Paris Agreement recognized in 2015 cities have pledged climate actions that often exceed the scope and ambition of their national governments’ policies but there is scant evidence of these actions’ outcomes, largely because of the lack of reported emissions data. Here the authors utilize spatially explicit datasets relevant to urban carbon emissions and self-reported emissions data from European cities, and develops a machine-learning approach to predict and explore trends in city-scale mitigation.

    • Angel Hsu
    • Xuewei Wang
    • Nihit Goyal
    Article Open Access
  • Misinformation online can be shared by major political figures and organizations. Here, the authors developed a method to measure exposure to information from these sources on Twitter, and show how exposure relates to the quality of the content people share and their political ideology.

    • Mohsen Mosleh
    • David G. Rand
    Article Open Access
  • The COVID-19 pandemic has stimulated an important changes in online information access. Here, the authors analyse everyday web search interactions across 25,150 US ZIP codes revealing significant differences in how digital informational resources are mobilized by different communities.

    • Jina Suh
    • Eric Horvitz
    • Tim Althoff
    Article Open Access

Subjects within Scientific community and society

  • This Comment piece summarises current challenges regarding routine vaccine uptake in the context of the COVID-19 pandemic and provides recommendations on how to increase uptake. To implement these recommendations, the article points to evidence-based resources that can support health-care workers, policy makers and communicators.

    • Cornelia Betsch
    • Philipp Schmid
    • Amanda Garrison
    Comment Open Access
  • Disability has too often been peripheral to efforts to widen the STEMM pipeline, hampering research quality and innovation. Inspired by change in education delivery and research collaborations during the pandemic, we offer a structure for efforts to recruit and retain disabled scientists and practitioners.

    • Siobhán M. Mattison
    • Logan Gin
    • Katherine Wander
    Comment Open Access
  • The rapid expansion and globalization of the seaweed production industry, combined with rising seawater temperatures and coastal eutrophication, has led to an increase in infectious diseases and pest outbreaks. Here, we propose a novel Progressive Management Pathway for improving Seaweed Biosecurity.

    • Elizabeth J. Cottier-Cook
    • Jennefe P. Cabarubias
    • Melba G. Bondad-Reantaso
    Comment Open Access
  • Association genetic studies and genome-scale CRISPR screens have recently identified ARF3 and TMEM251/LYSET/GCAF as Golgi-resident factors essential to brain and skeletal development. Here we discuss how even though the consequences of mutations in these genes affect endosomal and lysosomal compartments, the problem originates in the Golgi complex and may involve either the identity of the carrier vesicles or that of cargo molecules.

    • Vincent El Ghouzzi
    • Gaelle Boncompain
    Comment Open Access
  • Since 2020 Nature Communications has been considering Registered Reports for publication in the areas of cognitive neuroscience, human behaviour and psychology, and epidemiology. We are excited to announce the publication of our first Registered Report. With this milestone, we also want to open the format to all other areas of research.

    Editorial Open Access
  • We recently published our first Registered Report entitled ‘Value-free random exploration is linked to impulsivity’. We believe the format offers many benefits to strengthen hypothesis-driven research and are keen to share our experience with our readers as we open up the format to all fields of research. We interviewed the authors of the manuscript (Magda Dubois and Tobias Hauser) and one of the reviewers (Trevor Robbins) about their experience of the review process. We are editorially committed to take their comments on board to further improve our guidance and to optimally support our future authors.

    Q&A Open Access
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