A person receiving sound therapy through headphones and electrical stimulation on their tongue

Combining sound with tongue stimulation for the treatment of tinnitus

Michael Boedts and colleagues report positive efficacy and safety results of a nonsurgical treatment for tinnitus, using a device that combines sound therapy with electrical tongue stimulation.

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  • Vibrio parahaemolyticus Sequence Type 3 was first reported in India and expanded globally to areas with distinct climates including Latin America. In this study, the authors investigate the evolutionary mechanisms driving emergence of the strain in Latin America using 280 publicly available genomes and 32 samples newly sequenced in this study.

    • Amy Marie Campbell
    • Ronnie G. Gavilan
    • Jaime Martinez-Urtaza
    ArticleOpen Access
  • Optical nanoprobes with preferential tumour accumulation is often limited by inefficient amplification of biological signals. Here, the authors report a hydrophobic core-tunable nanoprobe orthogonally amplifying tumour microenvironmental signals and demonstrating clear delineation between malignant lesions and normal tissues on multiple tumour models.

    • Meijie Pan
    • Ruiyang Zhao
    • Yiguang Wang
    ArticleOpen Access
  • The search for biomarkers associated with konzo disease has been a long-standing question within the research community. Here, the authors have uncovered a potential biomarker for konzo that is associated with the ability to manage oxidative damage.

    • Matthew S. Bramble
    • Victor Fourcassié
    • Arnaud Droit
    ArticleOpen Access
  • Dissecting the associations between exposure to environmental pollution and cancer risk remains crucial. Here, the authors evaluate the impact of air and water pollution on cancer incidence in China using a spatial evaluation system and show that most excess cancer cases occurred in areas with the highest level of co-pollution.

    • Jingmei Jiang
    • Luwen Zhang
    • Chengyu Jiang
    ArticleOpen Access

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  • Plant nitrogen source in the soil is challenging to track. Compiling the most comprehensive global δ15N dataset, a new study shows the plant use of various available soil nitrogen forms (ammonium, nitrate, and organic nitrogen) is strongly controlled by temperature.

    • Lixin Wang
    CommentOpen Access
  • Liang et al. present an industrial perspective on the evolving landscape of laser technology used in advanced LiDAR systems. The authors discuss recent trends, practical considerations within the industry, current challenges, and potential solutions, explicitly focusing on VCSEL/AR-VCSEL-based technologies and their strong potential for commercial LiDAR applications.

    • Dong Liang
    • Cheng Zhang
    • Yijie Huo
    CommentOpen Access
  • Neuronal activity consumes cellular energy and generates carbon dioxide (CO2). To counter this metabolic challenge, synaptic signalling communicates with nearby microvasculature to increase local blood flow. Is this process solely based on feedforward synaptic signalling, or is the generated CO2 also involved? This question was addressed in mice in a new Nature Communications publication by Tournissac and colleagues where they showed that neurovascular coupling is not affected by exogenous CO2 or its associated acidification.

    • Grant R. Gordon
    CommentOpen Access
  • The growing number of threats facing continental-scale transboundary water treaties warrants contemporary evaluation of not only the political and climatological conditions under which they were constructed, but also of how different management strategies for accommodating changes in those conditions can lead to treaty success or failure. We assess these threats by highlighting key attributes and vulnerabilities of water treaties across North America that frame a diverse set of future water management priorities. While these threats are ubiquitous globally, they are particularly pronounced in North America where water-abundant basins along the border between the United States (US) and Canada contrast with arid basins along the border between the US and Mexico. We propose addressing these needs through a three-step call to action for management agencies, politicians, and the public at large to embrace a holistic perspective on transboundary water agreements.

    • Andrew Gronewold
    • Jenna Bednar
    • Jon Allan
    CommentOpen Access
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