Correspondence in scientific journals is an essential mechanism for mediating scientific debates, but emerging online technologies offer new ways to foster scientific communication.
Volume 4 Issue 6, June 2008
News & Views
A new pharmacological inhibitor of the Cdc7 protein kinase can block replication initiation without activating the replication checkpoint, thus validating replication initiation as a new target class for cancer cell chemotherapy.
Lysine methyltransferases are well-known regulators of transcription through their methylation of histone lysine residues. Now high-throughput peptide arrays reveal non-histone substrates of G9a/KMT3C, which was previously known as a euchromatic histone H3K9-specific methyltransferase.
The search for new antimalarial strategies takes a step forward with the discovery of a small parasitocidal molecule that inhibits a calcium-dependent protein kinase and may thereby interfere with parasite motility.
Crosstalk between histone modifications plays an important role in transcriptional regulation. In a recent study, an elegant chemical synthesis approach has been used to study the intricate relationship between two modifications associated with active transcription.
Biosynthesis of essential hormones is often complex and redundant. Two independent genetic screens have converged to support a previously conjectured auxin biosynthetic pathway that is responsible for providing auxin during plant development and in response to environmental cues.