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Volume 18 Issue 9, September 2022

Repairing the sheath

Myelin membranes wrap around axons to support neural health. The cover image depicts an oligodendrocyte (shown in purple), the specialized glial cell that produces central nervous system myelin. Enhancing myelin repair, or ‘remyelination’, remains an attractive therapeutic approach for replacing lost oligodendrocytes in diseases such as multiple sclerosis.

See Caprariello & Adams

IMAGE: Ella Maru Studio. COVER DESIGN: Alex Wing.

Research Highlights

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News & Views

  • Controlling kinase inhibitors’ residence time via reversible covalent binding is of high interest in drug discovery. Tuning reversible covalent binding kinetics using a pan-kinase inhibitor that reacts with the catalytic lysine enabled exquisite temporal selectivity in vitro and in vivo.

    • Fleur M. Ferguson
    News & Views
  • A directed evolution approach delivers ribosomes with highly functional tethered subunits. Combining the decoding and peptidyl transferase activities of the ribosome into a single entity sets the scene for more efficient protein engineering technologies.

    • Aleksandra Filipovska
    • Oliver Rackham
    News & Views
  • Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

    • Beomjong Song
    • Sangsu Bae
    News & Views
  • Elucidating the interactions between serum protein-bound nanoparticles and cell-surface receptors typically operates on a per protein–receptor interaction basis. Integration of omic approaches for testing thousands of interactions unbiasedly reveals important interactions that drive cellular uptake of nanoparticles.

    • Cecilia Ka Wing Chan
    • Sze Ho Gwyneth Lau
    • Chung Hang Jonathan Choi
    News & Views
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Perspectives

  • Loss of myelin causes neurological symptoms for patients with multiple sclerosis. This Perspective details how phenotypic screening has accelerated discovery efforts toward potential ‘remyelinating therapeutics’.

    • Andrew V. Caprariello
    • Drew J. Adams
    Perspective
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