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Volume 18 Issue 8, August 2022

Illuminating the synapse

Photocatalytic cell tagging (PhoTag) enables the selective introduction of chemical tags within cell–cell contact interfaces via visible light activation of localized flavin photocatalysts. The cover image depicts immune synapses selectively and covalently tagged with biotin tyramide through PhoTag technology.

See Oslund et al.

Image credit: Yizhengillustration. Cover Design: Alex Wing.

Research Highlights

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News & Views

  • Protein arginine methyltransferases (PRMTs) are overexpressed in many cancer types, including triple-negative breast cancer (TNBC). A new study shows that a reversible inhibitor of type I PRMTs suppresses TNBC tumor growth by inducing a viral mimicry response with retained introns.

    • Nivine Srour
    • Stéphane Richard
    News & Views
  • Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new insight into the process, especially for the intriguing ‘non-classical’ MHC-I protein MR1, with implications for fundamental immunology and the development of novel immunotherapies.

    • Tatiana J. Rosales
    • Brian M. Baker
    News & Views
  • In the post-genomic era, many genes and regulatory elements remain uncharacterized, including riboswitches — RNA structures that control gene expression by directly binding metabolites. Here, a new type of metal-responsive riboswitch that senses sodium cations expands the bacterial Na+ metabolic repertoire.

    • Lauren Waters
    News & Views
  • Chemical probes are powerful tools for the discovery of ligand-binding and drug-target sites on proteins. A new software helps to profile their performance in chemoproteomic applications.

    • Alexander Leitner
    News & Views
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  • Emerging evidence shows that ubiquitination can occur on nonlysine residues and nonproteinaceous substrates. This perspective summarizes the recent discoveries in noncanonical ubiquitination and advocates the development of chemical biology tools for new substrate identification and mechanistic dissection.

    • Daniel R. Squair
    • Satpal Virdee
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Amendments & Corrections

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