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Volume 17 Issue 1, January 2021

Volume 17 Issue 1

Protected by the peroxisome

In yeast, targeting potentially toxic proteins to the peroxisome (here demonstrated with yellow fluorescent protein) protects the cell from harmful effects. Using this peroxisome-targeting approach with the toxic enzyme norcoclaurine synthase enables increased production of (S)-reticuline and other alkaloids.

See Grewal et al.

IMAGE: Parbir Grewal and Jordan Baker. COVER DESIGN: Alex Wing.


  • Feature |

    We asked a collection of chemical biologists, “What is the most exciting frontier area in chemical biology and what key technology is needed to advance knowledge and applications in this area?” and reveal some of the perspectives we received.

News & Views

  • News & Views |

    Bariatric surgery causes high rates of remission of type 2 diabetes; however, the mechanisms remain unresolved. A new study identifies cholic-acid-7-sulfate as a novel contributor to the metabolic benefits of bariatric surgery and an attractive target for treatment of type 2 diabetes.

    • Bethany P. Cummings
  • News & Views |

    Reprogramming requires resetting the epigenome toward a pluripotent chromatin state. A new chemical screen identifies epigenetic and signaling roadblocks for reprogramming of human somatic cells, with the inhibition of these roadblocks resulting in a more permissive epigenome for reprogramming.

    • Maximilian W. D. Raas
    • Dick W. Zijlmans
    • Hendrik Marks
  • News & Views |

    Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

    • Yang Gu
    • Peng Xu

Review Articles

  • Review Article |

    This Review summarizes recent advances in CRISPR–Cas regulation mechanisms by natural biomolecules that enhance or inhibit CRIPSR–Cas immunity, as well as their applications in CRISPR biology and technologies.

    • Haridha Shivram
    • Brady F. Cress
    • Jennifer A. Doudna



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