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Volume 16 Issue 7, July 2020

Volume 16 Issue 7

Generating the barrier

The cover depicts conformational dynamics of a short disordered segment of the monomeric yeast prion protein Sup35. This segment modulates the species-specific seeding activity, and a methylene group alone within a side chain of a glutamine residue is sufficient to drastically alter the species specificity of prion transmission.

See Shida et al.

IMAGE: Art Action Inc., Takaya Fukui. COVER DESIGN: Erin Dewalt

Obituary

  • Obituary |

    Rolf Huisgen left us on 26 March 2020, just three months shy of his 100th birthday. His work has had an enormous influence on chemical biology, ranging from new methods for the synthesis of chemical probes to “click chemistry” and its application to in vivo bioconjugation.

    • Dirk Trauner

Research Highlights

News & Views

  • News & Views |

    Glucose 6-phosphate dehydrogenase (G6PD) stands at the head of the pentose phosphate pathway, which is responsible for nucleotide synthesis. The identification and thorough validation of an improved G6PD inhibitor provide a valuable new tool compound for studying metabolism.

    • Michael E. Pacold
  • News & Views |

    The enzyme 5-lipoxygenase (5-LOX) initiates the biosynthesis of leukotrienes (LT), potent mediators of the inflammatory response. The first crystal structures of two complexes of inhibitor bound to 5-LOX reveal the functional consequences of the binding, including a change in the regiospecificity toward a 12/15-lipoxygenating enzyme.

    • Homero Rubbo
    • Irene Wood

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