Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 16 Issue 4, April 2020

Seeking small proteins

Seeking small proteins. Exploration of translation by combining de novo transcriptome assembly and ribosome profiling illuminated the existence of thousands of previously unannotated small open reading frames that encode microproteins.

See Martinez et al

IMAGE: Amy Cao. COVER DESIGN: Erin Dewalt

Research Highlights

Top of page ⤴

News & Views

  • Phospholipase D (PLD) regulates various cellular functions through the signaling lipid phosphatidic acid (PA). New crystal structures of human PLD1 and PLD2 reveal a catalytic mechanism, inhibitor binding, and regulation, enabling future structure-based inhibitor design and functional studies of PLD.

    • Lei Zheng
    • Guangwei Du
    News & Views
  • Tyrosine sulfation is a common post-translational modification known to play critical roles in multiple bioprocesses. A cleverly engineered mammalian expanded genetic code now enables the direct co-translational incorporation of tyrosine sulfates into proteins to study their function in cellular contexts.

    • Chang C. Liu
    News & Views
  • The mechanisms by which bioactive drugs get into their target cells is a question that has been greatly neglected. A new survey with CRISPR–Cas9 shows the widespread importance of protein transporters called solute carriers (SLCs).

    • Douglas B. Kell
    News & Views
Top of page ⤴


  • This Perspective describes the chemical and biophysical principles common to all bifunctional, proximity-inducing small molecules. It also discusses the underappreciated diversity of their chemical structures and biological mechanisms.

    • Christopher J. Gerry
    • Stuart L. Schreiber
Top of page ⤴

Brief Communications

Top of page ⤴


Top of page ⤴

Amendments & Corrections

Top of page ⤴


Quick links