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Volume 16 Issue 3, March 2020

Volume 16 Issue 3

Targeting bacterial bile salts

The bacteria of the human microbiota use bile salt hydrolases (BSHs) to generate dozens of secondary bile acids that can bind to host receptors, including nuclear receptors and G-protein-coupled receptors. A covalent inhibitor generated by appending an electrophile to the sterol core of a bile acid can inhibit all of the BSH activity in rodent microbiota and could prove useful for understanding the effects of bile acids on host physiology.

See Adhikari et al

IMAGE: Leah Bury COVER DESIGN: Erin Dewalt

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