Th17 cells get inflamed
Several compounds, including the HIV protease inhibitor ritonavir and a synthetic peptide, disrupt the interaction between CD95 (blue ribbon) and PLCγ1 (orange ribbon) by mimicking the structure of the CD95/Fas calcium-inducing domain, which mediates binding to PLCγ1 at the membrane (grey sticks). These inhibitors limit calcium signaling and Th17 migration driven by the soluble CD95 ligand, s-CD95L, as well as inflammation in lupus mice. In HIV patients treated with HIV protease inhibitors, PBMCs show impairment of the non-apoptotic pro-migratory CD95 pathway.
See Legembre et al.