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Volume 14 Issue 9, September 2018

Volume 14 Issue 9

A spiny probe

A computational design approach was used to obtain a glycine-binding protein that could be developed into a genetically encoded FRET-based optical sensor, GlyFS. GlyFS was used to monitor hippocampal glycine levels in brain tissue, with the sensitivity to determine differences in spines and shafts, as well dynamics induced by high- and low-frequency stimulation. Shown here are astroglial branches in grey and a single dendritic fragment in red.

See Henneberger et al.

Image: Michel Herde. Cover Design: Erin Dewalt.

Research Highlights

News & Views

  • News & Views |

    Establishment of the germ cell lineage requires post-transcriptional regulation of mRNAs, yet the underlying molecular mechanisms are not fully understood in vertebrates. A small-molecule inhibitor of germ cell formation reveals a noncanonical translation system used in zebrafish embryos.

    • Yuichiro Mishima
  • News & Views |

    The design of spiraling cross-α amyloid-like structures reveals fascinating supermolecular fibrils of diverse compactness and stability. The small sequence variations governing cross-α self-assembly properties concur with amyloids being basic building blocks of life and natural targets for microbial structural mimicry.

    • Meytal Landau
  • News & Views |

    A computational design approach was used to develop a genetically encoded FRET-based optical sensor that is aimed at monitoring extracellular glycine levels in brain tissue with the sensitivity and resolution to discern differences in dendritic spine and shaft environment and concentration dynamics upon afferent stimulation.

    • Dmitri A. Rusakov

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