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Volume 14 Issue 7, July 2018

Volume 14 Issue 7

Metal on the mind

The cover depicts the distribution of copper in brain tissue slices of larval zebrafish, imaged using the fluorescent probe Copper Fluor-4 and stylized to appear as an oil painting. Rows depict various developmental stages of either wild-type or copper-deficient zebrafish, while columns depict anterior-to-posterior slices (left to right).

See Chang, C et al.

Image: Tong Xiao and Cheri Ackerman. Cover Design: Erin Dewalt

Research Highlights

News & Views

  • News & Views |

    Understanding how metals contribute to brain function is a major health priority. A new study combining pharmacology and genetics implicates the accumulation of copper in a brain arousal center as a regulator of zebrafish activity.

    • Jason Rihel
  • News & Views |

    The ability to subvert E3 ubiquitin ligases with small-molecule drugs offers tremendous promise for drug discovery. A new study demonstrates how structural and computational techniques can engineer and exploit unnatural protein–protein interfaces to design selective protein degraders.

    • Philip P. Chamberlain
  • News & Views |

    Single-molecule techniques combined with molecular dynamics simulations allowed visualization of a surprisingly high level of conformational homogeneity in the transport cycle of an ABC import system, BtuCD-F, and revealed an unexpected tight coupling of distinct conformational states responsible for vitamin B12 binding, transport and release.

    • Lutz Schmitt

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