Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 14 Issue 11, November 2018

Preventing codon slippage

The cover depicts the structure of tRNAMet bearing an N 4-acetylcytidine (ac4C) modification at the first position of the anticodon. The acetyltransferase TmcAL introduces the ac4C modification, and loss of TmcAL results in misdecoding of the AUA codon.

See Taniguchi et al.

Image: Be Design Inc. Cover design: Erin Dewalt

Research Highlights

Top of page ⤴

News & Views

  • The prodrug dimethyloxalylglycine (DMOG) is a well-known tool compound used to study hypoxia. New findings reveal that DMOG also inhibits glutamine metabolism and can be exploited to selectively kill some cancer cells, highlighting important caveats when using DMOG for hypoxia studies.

    • Barbara S. Nelson
    • Daniel M. Kremer
    • Costas A. Lyssiotis
    News & Views
  • The proteome-wide application of a probe that selectively labels cysteine residues oxidized to the sulfinic acid form reveals the mammalian S-sulfinylome and uncovers novel substrates of the sulfinyl reductase sulfiredoxin, opening yet unexplored realms of cysteine-based redox regulation.

    • Sophie Rahuel-Clermont
    • Michel B. Toledano
    News & Views
  • A Donnan equilibrium causes an influx of chloride ions into the Escherichia coli periplasm when the bacterium finds itself in gastric fluid. The combination of low pH and high anion concentration drives proteins to aggregate, a potentially lethal event unless prevented by specific chaperones.

    • Colin Kleanthous
    News & Views
Top of page ⤴


Top of page ⤴


Quick links