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  • We asked a collection of chemical biologists: “What is the most exciting frontier area in chemical biology, and what key technology is needed to advance knowledge and applications at this frontier?”

    Q&A
  • Abundant frontiers at the interface of chemistry and biology promise another decade of technological innovation and scientific discovery by chemical biologists.

    Editorial
  • Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.

    • Anna K Mapp
    • Rachel Pricer
    • Steven Sturlis
    Commentary
  • X-ray crystallography, the workhorse of structural biology, has been revolutionized by the advent of serial femtosecond crystallography using X-ray free electron lasers. Here, the fast pace and history of discoveries are discussed together with current challenges and the method's great potential to make new structural discoveries, such as the ability to generate molecular movies of biomolecules at work.

    • Petra Fromme
    Commentary