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Slicer and the Argonautes

Nature Chemical Biology volume 3, pages 36–43 (2007)Cite this article

Abstract

Though they started out as somewhat mysterious components of the RNAi effector complexes, Argonaute proteins have since taken center stage in RNAi gene silencing. They interact with small RNAs to effect gene silencing in all RNAi-related pathways known so far. We will review the dramatic advances in our understanding of the role of the Argonautes in RNAi through studies of their structure and function.

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Figure 1: Pathways of post-transcriptional gene silencing.
Figure 2: The crystal structure of Argonaute from P. furiosus.
Figure 3: The three clades of the Argonautes.
Figure 4: Model for the role of slicing in TGS in S. pombe.

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Acknowledgements

RNAi is a flourishing field with a great deal of wonderful studies, some of which we were not able to cite in this short survey, and for that we apologize. This work was supported by a grant from the US National Institutes of Health to L.J. (R01-GM072659).

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  1. W.M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, 11724, New York, USA

    Niraj H Tolia & Leemor Joshua-Tor

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Correspondence to Leemor Joshua-Tor.

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Tolia, N., Joshua-Tor, L. Slicer and the Argonautes. Nat Chem Biol 3, 36–43 (2007). https://doi.org/10.1038/nchembio848

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