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Drug discovery

Controlling protein SUMOylation

A potent and selective inhibitor of protein SUMOylation, a ubiquitin-like post-translational modification, has been developed, shedding light on the potential for developing new classes of anticancer therapeutics.

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Figure 1: Inhibition of protein SUMOylation with a small molecule.

References

  1. He, X. et al. Nat. Chem. Biol. 13, 1164–1171 (2017).

    Article  CAS  Google Scholar 

  2. Gareau, J.R. & Lima, C.D. Nat. Rev. Mol. Cell Biol. 11, 861–871 (2010).

    Article  CAS  Google Scholar 

  3. Geiss-Friedlander, R. & Melchior, F. Nat. Rev. Mol. Cell Biol. 8, 947–956 (2007).

    Article  CAS  Google Scholar 

  4. Kessler, J.D. et al. Science 335, 348–353 (2012).

    Article  CAS  Google Scholar 

  5. Yu, B. et al. Proc. Natl. Acad. Sci. USA 112, E1724–E1733 (2015).

    Article  CAS  Google Scholar 

  6. Brownell, J.E. et al. Mol. Cell 37, 102–111 (2010).

    Article  CAS  Google Scholar 

  7. Soucy, T.A. et al. Nature 458, 732–736 (2009).

    Article  CAS  Google Scholar 

  8. Demarque, M.D. et al. Gastroenterology 140, 286–296 (2011).

    Article  CAS  Google Scholar 

  9. Becker, J. et al. Nat. Struct. Mol. Biol. 20, 525–531 (2013).

    Article  CAS  Google Scholar 

Download references

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Correspondence to John S Schneekloth Jr.

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Schneekloth, J. Controlling protein SUMOylation. Nat Chem Biol 13, 1141–1142 (2017). https://doi.org/10.1038/nchembio.2496

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