The complex flavonoid montbretin A (MbA) is a powerful inhibitor of human pancreatic amylase (HPA) and a potential tool in the treatment of type 2 diabetes. The X-ray structure of the MbA–HPA complex now shows that a hydrophobic collapse of two phenol fragments in the structure of MbA is key to its activity.
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Bernardi, A., Sattin, S. A phenol sandwich fights diabetes. Nat Chem Biol 11, 635–636 (2015). https://doi.org/10.1038/nchembio.1888
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DOI: https://doi.org/10.1038/nchembio.1888
