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    This special issue presents a collection of articles exploring the foundations of chemical biology, reviewing some of the major technical and conceptual advances of the last decade, and imagining the future of this vibrant field.

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    Chemical biologists are asking and answering molecular level questions that expand our awareness and understanding of structural and functional variation. In this issue, we feature profiles, opinions and guides that highlight the complexity of the natural world.

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    This themed issue features a collection of articles that describe our current understanding of the functions of lipids and the chemical methods used to study them at the individual level and within the larger biological systems where they function.

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    Chemical biologists are making significant progress in discovering and characterizing high-quality chemical probes. In this issue, we feature Commentary and Review Articles that capture opinions and advances at the frontiers of chemical probe research.

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    This special issue contains a collection of articles that discuss our current understanding of protein dynamics and the methods used to study the dynamics of individual proteins and their interactions with the larger biological systems where they function.

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    Insights gained from advanced techniques and large datasets are charting new courses in enzymological research. In this issue, we feature a collection of articles highlighting the current ideas and future challenges that are redirecting research in the field.

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    Enhanced interactions between plant biology and chemical biology offer great potential for shared concepts, tools and insights that will advance each discipline. This special issue highlights emerging frontiers in plant chemical biology, with an emphasis on the networks of plant hormones that regulate plant growth and mediate plant interactions with their external environments.

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    Chemical biology and systems biology are beginning to intersect with increasing frequency, opening up opportunities for integrating new tools and concepts into both fields. In this issue, we highlight a number of exciting areas at the emerging interface of 'chemical systems biology'.

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    New mechanistic insights are extending our understanding of cooperativity in biochemical processes. In this issue, we feature a collection of articles highlighting current research and future challenges in exploring cooperative systems in chemistry and biology.

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    In this issue, we highlight important recent advances in understanding both the chemistry and biology of metals in biological systems. We also feature new tools and approaches that can be used to gain a better understanding of the roles that metal ions play in cells and in whole organisms. We hope this collection of articles highlights the excitement of the 'chemical biology' of metals.

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    Cells and organisms have developed specialized systems to observe and respond to variables within their local environments. In this issue, we feature a collection of articles that focus on how biological systems measure space and time.

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    Investigations into natural products have recently regained prominence with the increasing understanding of their biological significance and increasing recognition of the origin and function of their structural diversity. This issue highlights some of the major questions and advances in natural products research, from recent synthetic approaches to access complicated natural products to a new educational program which utilizes natural products as a basis for discovery-based research.