Volume 20

  • No. 3 March 2024

    Concentrated by condensates

    Small molecules can concentrate in diverse cellular compartments. The image, captured by two-photon microscopy, shows the accumulation of tryptanthrin, a quinazoline indole alkaloid and active ingredient in medicinal herbs, within biomolecular condensates and cytoplasmic organelles.

    See Kilgore et al.

  • No. 2 February 2024

    Peaks and valleys of GPCR signaling

    The spatial organization of GPCRs is closely associated with their signaling responses and cellular function. Kockelkoren et al. reveal that the spatial organization is energetic coupling of receptors to the curvature of the plasma membrane. The image depicts the landscape of GPCR distribution at the plasma membrane of living cells.

    See Kockelkoren et al.

  • No. 1 January 2024

    Living with lipid mimics

    Genetic code expansion (GCE) techniques are valuable for studying post-translational modifications by incorporating modified non-canonical amino acids into specific sites within target proteins. The image depicts lipidated proteins produced via GCE anchored to the membrane.

    See Ding et al.