Review Articles

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  • Protein condensates are subcellular structures that enrich and confine molecules in cells. This Review details how condensates can be engineered with responsiveness and on-demand functions, thus pushing cellular and metabolic engineering to a new level.

    • Zhi-Gang Qian
    • Sheng-Chen Huang
    • Xiao-Xia Xia
    Review Article
  • This Review introduces molecular features of the phase-separating biomolecules and how they affect phase-separation behavior in a complex intracellular environment, highlighting a complex interplay between structure, sequence and environment in the phase-separation process.

    • José A. Villegas
    • Meta Heidenreich
    • Emmanuel D. Levy
    Review Article
  • Several venomous predators and pathogens use insulins to capture prey and to manipulate host physiology. This Review provides an overview of the discovery and potential biomedical application of these and other weaponized hormones found in nature.

    • Sophie Heiden Laugesen
    • Danny Hung-Chieh Chou
    • Helena Safavi-Hemami
    Review Article
  • Succinate may have evolved as a signaling modality because its concentration reflects the redox state of the mitochondrial coenzyme Q pool, thus communicating to the rest of the cell and beyond about electron supply, oxygen tension and ATP demand.

    • Michael P. Murphy
    • Edward T. Chouchani
    Review Article
  • Lipid metabolism is a major regulator of T cell biology, and this Review Article highlights mechanisms by which diverse lipids modulate T cell signaling and opportunities for therapeutic intervention on targets within these immunological pathways.

    • Seon Ah Lim
    • Wei Su
    • Hongbo Chi
    Review Article
  • The Review summarized the recent progress in chemical probes and drug candidates for epigenetic writer enzymes and discussed the implication of targeting the chromatin regulatory landscape in cancer biology and therapy.

    • Andrew R. Conery
    • Jennifer L. Rocnik
    • Patrick Trojer
    Review Article
  • This Review surveys how resistance mutations to small molecules and recent mutagenesis technologies have driven biological discovery across diverse fields of inquiry.

    • Allyson M. Freedy
    • Brian B. Liau
    Review Article
  • This Review highlights the latest progress on the molecular basis of metabolite signals in regulating aging and longevity, as well as state-of-the-art technological advances in studying bioactive metabolites.

    • Yue Zhou
    • Guo Hu
    • Meng C. Wang
    Review Article
  • This Review summarizes the recent technical advances in probing RNA secondary structures and discusses their connection with RNA regulatory functions in various biological processes and future directions in RNA structure-probing methods.

    • Xi-Wen Wang
    • Chu-Xiao Liu
    • Qiangfeng Cliff Zhang
    Review Article
  • Cell–cell interactions and resulting signaling events drive key biological processes. This Review discusses the deconvolution of this complex biology through the development of tools for visualizing, chemically tagging and functionally exploiting these interactions.

    • Tyler J. Bechtel
    • Tamara Reyes-Robles
    • Rob C. Oslund
    Review Article
  • This Review summarizes recent progress in small-molecule probes used to address questions in cell division and appraises some emerging techniques that can be adapted to cell division studies.

    • Geng-Yuan Chen
    • Michael A. Lampson
    Review Article
  • Autophagy has been widely implicated in human health and disease. The most recent advances in developing small molecule probes for autophagy are presented, as well as the potential to use this process for targeted protein degradation.

    • Thomas Whitmarsh-Everiss
    • Luca Laraia
    Review Article
  • This Review summarizes recent advances in CRISPR–Cas regulation mechanisms by natural biomolecules that enhance or inhibit CRIPSR–Cas immunity, as well as their applications in CRISPR biology and technologies.

    • Haridha Shivram
    • Brady F. Cress
    • Jennifer A. Doudna
    Review Article
  • Ion channel structures reveal mechanisms of lipid action, including how channel gating is altered by direct binding of signaling lipids and those within the membrane itself, as well as mechanical and architectural effects of membrane lipids.

    • Mackenzie J. Thompson
    • John E. Baenziger
    Review Article