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  • Genome mining of Streptococcus mutans clinical samples led to the identification of a structurally unique polyketide/non-ribosomal peptide, mutanofactin-697, that promotes biofilm formation. This study highlights the unexplored functional potential of secondary metabolites and opens new avenues for inhibiting pathogenic processes.

    • Amber M. Scharnow
    • William M. Wuest
    News & Views
  • An approach based on enrichment of 5′ hydroxylated RNAs reveals a new self-cleaving ribozyme that maps to a very long non-protein-coding RNA in simians. The ribozyme is active only among hominin sequences, suggesting a recent acquisition of the activity.

    • Claire C. Chen
    • Andrej Lupták
    News & Views
  • YAP is a major downstream effector of the Hippo intracellular signaling pathway, with key roles in organ development, regeneration, and cancer biology. A small molecule that targets Annexin (ANX) acts through YAP to promote rapid epidermal tissue expansion.

    • Toshiro Moroishi
    News & Views
  • Acyl protein thioesterases are critical regulators of S-acylation, removing acyl chains from dynamically S-acylated proteins. A cytosolic deacylase, APT2, is S-acylated by zDHHC3 and zDHHC7 and is predicted to deform the lipid bilayer to extract acyl chains, capturing them within a hydrophobic pocket.

    • Jennifer Greaves
    News & Views
  • Characterization of cell death kinetics identifies new on- and off-target small-molecule modulators of ferroptosis and reveals a role of amino acid metabolism in regulating ferroptosis sensitivity.

    • Mariluz Soula
    • Kıvanç Birsoy
    News & Views
  • A genetically encoded real-time redox reporter reveals that H2O2-signaling peroxiredoxin (PRX) proteins couple yeast metabolic oscillations with the cell division cycle. This new PRX function suggests fresh avenues for exploring circadian regulation of cell division and cancer.

    • John S. O’Neill
    News & Views
  • High-throughput biochemical and biological analyses of disease-associated histone mutations reveal key residues in globular cores that affect chromatin remodeling, nucleosome stability, and stem cell pluripotency.

    • Kanishk Jain
    • Brian D. Strahl
    News & Views
  • Using an interdisciplinary approach, hydrogen-peroxide-induced phase separation in the intrinsically disordered regions of the TERMINATING FLOWER transcription factor proteins was shown to regulate the shoot apical meristem through repression of the floral identity gene called ANANTHA.

    • Christine H. Foyer
    News & Views
  • The cumbersome encoding of digital data to cellular DNA hinders the use of cells as living hard drives. A new approach transfers digital information directly into cellular DNA by converting electrical signals into stable and interpretable changes in the genomes of bacterial populations.

    • Santi Bhattarai-Kline
    • Sierra K. Lear
    • Seth L. Shipman
    News & Views
  • Yin Yang 1 (YY1) is a transcription factor involved in gene regulation. A recent study has revealed G-quadruplex structures as novel binding targets of YY1, and their interactions regulate DNA looping and gene expression.

    • Haizhou Zhao
    • Chun Kit Kwok
    News & Views
  • The plant cuticle has long been considered a barrier to volatile organic compound emission. New research reveals the paradoxical role of the cuticle as a barrier and facilitator of volatile emissions in hybrid petunia.

    • Samuel J. Livingston
    • A. Lacey Samuels
    News & Views
  • Re-channeling metabolic routes in Nicotiana benthamiana allows elucidation and reconstitution of the biosynthesis of the natural products momilactones A and B. Insights into how plants make these and other natural crop protection chemicals promise future biotechnologies for sustainable agriculture.

    • Trinh-Don Nguyen
    • Thu-Thuy T. Dang
    News & Views
  • A chemical screen identifies BET bromodomain inhibitors as inducers of an activated skin keratinocyte state that promotes the wound-healing capabilities of these cells. The study implicates epigenetic modifiers as potential targets for non-healing, chronic wounds.

    • Irene Ylivinkka
    • Sara A. Wickström
    News & Views
  • Directed evolution on the yeast cell surface enables the discovery of sortase variants with altered specificity capable of modifying Aβ peptides under physiologically relevant conditions.

    • James A. Van Deventer
    News & Views
  • Insects have many ways of disabling plant chemical defenses during feeding. Plant phloem feeders use surplus ingested sugar to block the activation of glucosinolate toxins, providing a target for precise resistance breeding.

    • Niels Agerbirk
    News & Views
  • Metabolic engineering offers the flexibility to meet market demand for bioactive natural products but can be hampered when a necessary protein or intermediate is toxic. In yeast, modifying the subcellular localization of biosynthetic enzymes can alleviate toxicity and increase production titer.

    • Yang Gu
    • Peng Xu
    News & Views
  • Transfer of ubiquitin onto target proteins requires controlled interplay between E2 conjugating enzymes and E3 ligases. The structure of a trapped E2~Ub/RCR E3 transfer intermediate provides novel insight into the diversity of mechanisms used to fine tune this relay.

    • Sonja Lorenz
    • Katrin Rittinger
    News & Views
  • Targeted small-molecule inhibition of BRAFV600E faces seemingly insurmountable obstacles in the clinic, such as rapid emergence of drug resistance. A recent study illustrates the potential of an alternative therapeutic strategy via PROTAC-mediated degradation of the oncogenic BRAF.

    • Joshua J. Feng
    • Chao Zhang
    News & Views
  • The ADGRL3 receptor, a member of the adhesion G-protein-coupled receptor family, is implicated in many neurological diseases. Using a novel technique involving controlled proteolysis of the receptor’s extracellular domain, this study demonstrated that ADGRL3 signals via G12/13 G proteins.

    • Eugenia V. Gurevich
    • Vsevolod V. Gurevich
    News & Views
  • The electrogenic bacterium Geobacter synthesizes conductive extracellular nanowires to facilitate electron transfer that powers respiration. A highly conductive form of these nanowires is now revealed to be composed of oligomers of an 8-heme cytochrome, OmcZ.

    • Thomas A. Clarke
    • Marcus J. Edwards
    News & Views