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Phase separation is an important mechanism for biomolecule condensate assembly and is involved in multiple biological activities. Understanding its molecular mechanism provides a unique perspective for gaining insights into its role in cellular physiology and for developing new tools for the manipulation of cellular function.
Chemical methods that integrate analytical and quantitative measurements of metabolites with the ability to alter metabolic processes offer powerful tools for modulating biology and physiology.
Advances in cryo-electron microscopy combined with improved computational tools for structural modeling have provided new insights into the basis of G-protein-coupled receptor–effector interactions.
