Editorials

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  • Chemical biologists are uniquely positioned to uncover and precisely manipulate the molecular basis of interactions between microbiomes and their hosts.

    Editorial
  • The development of chemical tools and small-molecule inhibitors enables the resolution of critical cellular processes with high spatial and temporal precision.

    Editorial
  • This themed issue features a collection of articles that explore long-standing questions in the study of lipids and membranes.

    Editorial
  • Targeted protein degradation provides a powerful complement to small-molecule inhibition in modulating protein activity and allows access to otherwise intractable drug targets.

    Editorial
  • Over the past decade and a half, chemical biology has crystallized as a discipline and extended its reach into new scientific areas, but the field’s greatest promise lies ahead.

    Editorial
  • Structural studies of GPCRs defining conformational states en route to activation and clarifying the mechanisms of activation, ligand bias, and signaling will be critical for discovering new drugs that target a range of diseases.

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  • Elucidating the mechanisms by which biomolecules are chemically modified and how these alterations regulate biological pathways represents a leading frontier in chemical biology.

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  • Biosynthetic pathways harbor diverse enzyme functions, and identifying those that catalyze unusual or synthetically challenging transformations offers new routes for biocatalytic development.

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  • The growing intersection between chemical tools and principles and developmental biology is providing new insights into the molecular-level details of developmental processes.

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  • The innovation and optimization of optogenetic tools are providing new insights into biological and cellular processes with unparalleled spatiotemporal resolution.

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  • Abundant frontiers at the interface of chemistry and biology promise another decade of technological innovation and scientific discovery by chemical biologists.

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  • Improved tools and expanding knowledge are enabling new insights into the biochemical basis, ecological roles and promising applications of natural product biosynthesis.

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  • Chemical probes are proven tools for biological research and early-stage drug development, but how can chemical biologists make them more useful to the broader scientific community?

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  • Chemical biology may elude simple definitions, but there remains no question that chemical biologists have crafted a compelling interdisciplinary narrative that advances science and benefits society.

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  • Structural biology advances have democratized access to biomolecular snapshots, but high standards must be maintained to ensure their utility.

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  • Nature and the Nature journals start offering anonymity to authors during the peer-review process.

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  • Chemical biology has much to contribute to the global effort to reduce hunger, improve food safety and support sustainable agriculture.

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  • New insights into the regulatory mechanisms of protein folding and turnover are informing the development of chemical tools and small molecules to treat proteostasis disorders.

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  • New computational and biochemical tools and informatic rules should spur research on a relatively underexplored class of molecules.

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  • Big Data analytic tools will be invaluable for extracting meaning from microbiome data to enable new solutions to global health problems and provide new insights into microbiology.

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