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Article |
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA
- Daisuke Kaida
- , Hajime Motoyoshi
- , Etsu Tashiro
- , Takayuki Nojima
- , Masatoshi Hagiwara
- , Ken Ishigami
- , Hidenori Watanabe
- , Takeshi Kitahara
- , Tatsuhiko Yoshida
- , Hidenori Nakajima
- , Tokio Tani
- , Sueharu Horinouchi
- & Minoru Yoshida
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Identification and mechanistic characterization of low-molecular-weight inhibitors for HuR
- Nicole-Claudia Meisner
- , Martin Hintersteiner
- , Kurt Mueller
- , Roman Bauer
- , Jan-Marcus Seifert
- , Hans-Ulrich Naegeli
- , Johannes Ottl
- , Lukas Oberer
- , Christian Guenat
- , Serge Moss
- , Nathalie Harrer
- , Maximilian Woisetschlaeger
- , Christof Buehler
- , Volker Uhl
- & Manfred Auer
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Article |
Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer
- Anna Rodina
- , Maria Vilenchik
- , Kamalika Moulick
- , Julia Aguirre
- , Joungnam Kim
- , Anne Chiang
- , Julie Litz
- , Cristina C Clement
- , Yanlong Kang
- , Yuhong She
- , Nian Wu
- , Sara Felts
- , Peter Wipf
- , Joan Massague
- , Xuejun Jiang
- , Jeffrey L Brodsky
- , Geoffrey W Krystal
- & Gabriela Chiosis
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Article |
Calcium Green FlAsH as a genetically targeted small-molecule calcium indicator
- Oded Tour
- , Stephen R Adams
- , Rex A Kerr
- , Rene M Meijer
- , Terrence J Sejnowski
- , Richard W Tsien
- & Roger Y Tsien
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Probing the dynamics of O-GlcNAc glycosylation in the brain using quantitative proteomics
- Nelly Khidekel
- , Scott B Ficarro
- , Peter M Clark
- , Marian C Bryan
- , Danielle L Swaney
- , Jessica E Rexach
- , Yi E Sun
- , Joshua J Coon
- , Eric C Peters
- & Linda C Hsieh-Wilson
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Zinc pyrithione-mediated activation of voltage-gated KCNQ potassium channels rescues epileptogenic mutants
- Qiaojie Xiong
- , Haiyan Sun
- & Min Li
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Article |
The Cfd1–Nbp35 complex acts as a scaffold for iron-sulfur protein assembly in the yeast cytosol
- Daili J A Netz
- , Antonio J Pierik
- , Martin Stümpfig
- , Ulrich Mühlenhoff
- & Roland Lill
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Structure-guided development of affinity probes for tyrosine kinases using chemical genetics
- Jimmy A Blair
- , Daniel Rauh
- , Charles Kung
- , Cai-Hong Yun
- , Qi-Wen Fan
- , Haridas Rode
- , Chao Zhang
- , Michael J Eck
- , William A Weiss
- & Kevan M Shokat
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Article |
TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli
- Thomas Voets
- , Grzegorz Owsianik
- , Annelies Janssens
- , Karel Talavera
- & Bernd Nilius
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Activating gene expression in mammalian cells with promoter-targeted duplex RNAs
- Bethany A Janowski
- , Scott T Younger
- , Daniel B Hardy
- , Rosalyn Ram
- , Kenneth E Huffman
- & David R Corey
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Article |
Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites
- Rubén M Buey
- , Enrique Calvo
- , Isabel Barasoain
- , Oriol Pineda
- , Michael C Edler
- , Ruth Matesanz
- , Gemma Cerezo
- , Christopher D Vanderwal
- , Billy W Day
- , Erik J Sorensen
- , Juan Antonio López
- , José Manuel Andreu
- , Ernest Hamel
- & J Fernando Díaz
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Article |
CsoR is a novel Mycobacterium tuberculosis copper-sensing transcriptional regulator
- Tong Liu
- , Arati Ramesh
- , Zhen Ma
- , Sarah K Ward
- , Limei Zhang
- , Graham N George
- , Adel M Talaat
- , James C Sacchettini
- & David P Giedroc
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Electrostatic couplings in OmpA ion-channel gating suggest a mechanism for pore opening
- Heedeok Hong
- , Gabor Szabo
- & Lukas K Tamm
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Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance
- Campbell McInnes
- , Aveek Mazumdar
- , Mokdad Mezna
- , Christopher Meades
- , Carol Midgley
- , Fred Scaerou
- , Lee Carpenter
- , Mairi Mackenzie
- , Paul Taylor
- , Malcolm Walkinshaw
- , Peter M Fischer
- & David Glover
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Probing cell-division phenotype space and Polo-like kinase function using small molecules
- Ulf Peters
- , Joseph Cherian
- , Jeffrey H Kim
- , Benjamin H Kwok
- & Tarun M Kapoor
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Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret
- Sandra Schlee
- , Paul Carmillo
- & Adrian Whitty
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Nitric oxide activates TRP channels by cysteine S-nitrosylation
- Takashi Yoshida
- , Ryuji Inoue
- , Takashi Morii
- , Nobuaki Takahashi
- , Shinichiro Yamamoto
- , Yuji Hara
- , Makoto Tominaga
- , Shunichi Shimizu
- , Yoji Sato
- & Yasuo Mori
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Article |
Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
- Karson S Putt
- , Grace W Chen
- , Jennifer M Pearson
- , Joseph S Sandhorst
- , Martin S Hoagland
- , Jung-Taek Kwon
- , Soon-Kyung Hwang
- , Hua Jin
- , Mona I Churchwell
- , Myung-Haing Cho
- , Daniel R Doerge
- , William G Helferich
- & Paul J Hergenrother
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Article |
Histone deacetylase inhibitors reverse gene silencing in Friedreich's ataxia
- David Herman
- , Kai Jenssen
- , Ryan Burnett
- , Elisabetta Soragni
- , Susan L Perlman
- & Joel M Gottesfeld
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Article |
Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid–type III polyketide synthase
- Michael B Austin
- , Tamao Saito
- , Marianne E Bowman
- , Stephen Haydock
- , Atsushi Kato
- , Bradley S Moore
- , Robert R Kay
- & Joseph P Noel
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Article |
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
- Sruti Shiva
- , Xunde Wang
- , Lorna A Ringwood
- , Xueying Xu
- , Susan Yuditskaya
- , Vidhya Annavajjhala
- , Hiroaki Miyajima
- , Neil Hogg
- , Zena Leah Harris
- & Mark T Gladwin
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Article |
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo
- M Germana Sanna
- , Sheng-Kai Wang
- , Pedro J Gonzalez-Cabrera
- , Anthony Don
- , David Marsolais
- , Melanie P Matheu
- , Sindy H Wei
- , Ian Parker
- , Euijung Jo
- , Wei-Chieh Cheng
- , Michael D Cahalan
- , Chi-Huey Wong
- & Hugh Rosen
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Article |
Combinatorial chemistry identifies high-affinity peptidomimetics against α4β1 integrin for in vivo tumor imaging
- Li Peng
- , Ruiwu Liu
- , Jan Marik
- , Xiaobing Wang
- , Yoshikazu Takada
- & Kit S Lam
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Visualization of nitric oxide in living cells by a copper-based fluorescent probe
- Mi Hee Lim
- , Dong Xu
- & Stephen J Lippard
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The nongenotoxic carcinogens naphthalene and para-dichlorobenzene suppress apoptosis in Caenorhabditis elegans
- David Kokel
- , Yehua Li
- , Jun Qin
- & Ding Xue
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Article |
Identifying off-target effects and hidden phenotypes of drugs in human cells
- Marnie L MacDonald
- , Jane Lamerdin
- , Stephen Owens
- , Brigitte H Keon
- , Graham K Bilter
- , Zhidi Shang
- , Zhengping Huang
- , Helen Yu
- , Jennifer Dias
- , Tomoe Minami
- , Stephen W Michnick
- & John K Westwick
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Article |
Proteomic profiling of metalloprotease activities with cocktails of active-site probes
- Stephan A Sieber
- , Sherry Niessen
- , Heather S Hoover
- & Benjamin F Cravatt
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Article |
Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish
- Peter E Bayliss
- , Kimberly L Bellavance
- , Geoffrey G Whitehead
- , Joshua M Abrams
- , Sandrine Aegerter
- , Heather S Robbins
- , Douglas B Cowan
- , Mark T Keating
- , Terence O'Reilly
- , Jeanette M Wood
- , Thomas M Roberts
- & Joanne Chan
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Article |
Functional characterization of IRESes by an inhibitor of the RNA helicase eIF4A
- Marie-Eve Bordeleau
- , Ayaka Mori
- , Monika Oberer
- , Lisa Lindqvist
- , Louisa S Chard
- , Tatsuo Higa
- , Graham J Belsham
- , Gerhard Wagner
- , Junichi Tanaka
- & Jerry Pelletier
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Article |
A functional genomics approach to the mode of action of apratoxin A
- Hendrik Luesch
- , Sumit K Chanda
- , R Marina Raya
- , Paul D DeJesus
- , Anthony P Orth
- , John R Walker
- , Juan Carlos Izpisúa Belmonte
- & Peter G Schultz
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Article |
Allosteric inhibitors of Bcr-abl–dependent cell proliferation
- Francisco J Adrián
- , Qiang Ding
- , Taebo Sim
- , Anastasia Velentza
- , Christine Sloan
- , Yi Liu
- , Guobao Zhang
- , Wooyoung Hur
- , Sheng Ding
- , Paul Manley
- , Jürgen Mestan
- , Doriano Fabbro
- & Nathanael S Gray
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Article |
Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway
- Rebecca A Butcher
- , Bhupinder S Bhullar
- , Ethan O Perlstein
- , Gerald Marsischky
- , Joshua LaBaer
- & Stuart L Schreiber
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Article |
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited
- Brian P English
- , Wei Min
- , Antoine M van Oijen
- , Kang Taek Lee
- , Guobin Luo
- , Hongye Sun
- , Binny J Cherayil
- , S C Kou
- & X Sunney Xie
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Article |
Allosteric control of an ionotropic glutamate receptor with an optical switch
- Matthew Volgraf
- , Pau Gorostiza
- , Rika Numano
- , Richard H Kramer
- , Ehud Y Isacoff
- & Dirk Trauner
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Article |
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
- Henry E Pelish
- , Jeffrey R Peterson
- , Susana B Salvarezza
- , Enrique Rodriguez-Boulan
- , Ji-Long Chen
- , Mark Stamnes
- , Eric Macia
- , Yan Feng
- , Matthew D Shair
- & Tomas Kirchhausen
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Article |
Analysis of drug-induced effect patterns to link structure and side effects of medicines
- Anton F Fliri
- , William T Loging
- , Peter F Thadeio
- & Robert A Volkmann
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Article |
Entropy rectifies the Brownian steps of kinesin
- Yuichi Taniguchi
- , Masayoshi Nishiyama
- , Yoshiharu Ishii
- & Toshio Yanagida
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Article |
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
- Nathan S Bryan
- , Bernadette O Fernandez
- , Selena M Bauer
- , Maria Francisca Garcia-Saura
- , Alexandra B Milsom
- , Tienush Rassaf
- , Ronald E Maloney
- , Ajit Bharti
- , Juan Rodriguez
- & Martin Feelisch
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Article |
Neuronal synapse interaction reconstituted between live cells and supported lipid bilayers
- Sophie Pautot
- , Hanson Lee
- , Ehud Y Isacoff
- & Jay T Groves
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Article |
Preferential synapsis of loxP sites drives ordered strand exchange in Cre-loxP site-specific recombination
- Kaushik Ghosh
- , Chi-Kong Lau
- , Kushol Gupta
- & Gregory D Van Duyne
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Article |
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
- Valerian E Kagan
- , Vladimir A Tyurin
- , Jianfei Jiang
- , Yulia Y Tyurina
- , Vladimir B Ritov
- , Andrew A Amoscato
- , Anatoly N Osipov
- , Natalia A Belikova
- , Alexandr A Kapralov
- , Vidisha Kini
- , Irina I Vlasova
- , Qing Zhao
- , Meimei Zou
- , Peter Di
- , Dimitry A Svistunenko
- , Igor V Kurnikov
- & Gregory G Borisenko
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Article |
Inhibiting gene expression at transcription start sites in chromosomal DNA with antigene RNAs
- Bethany A Janowski
- , Kenneth E Huffman
- , Jacob C Schwartz
- , Rosalyn Ram
- , Daniel Hardy
- , David S Shames
- , John D Minna
- & David R Corey
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Article |
Inhibiting transcription of chromosomal DNA with antigene peptide nucleic acids
- Bethany A Janowski
- , Kunihiro Kaihatsu
- , Kenneth E Huffman
- , Jacob C Schwartz
- , Rosalyn Ram
- , Daniel Hardy
- , Carole R Mendelson
- & David R Corey
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Article |
Small-molecule interaction with a five-guanine-tract G-quadruplex structure from the human MYC promoter
- Anh Tuân Phan
- , Vitaly Kuryavyi
- , Hai Yan Gaw
- & Dinshaw J Patel
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Article |
RNA flexibility in the dimerization domain of a gamma retrovirus
- Christopher S Badorrek
- & Kevin M Weeks
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Article |
Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury
- Alexei Degterev
- , Zhihong Huang
- , Michael Boyce
- , Yaqiao Li
- , Prakash Jagtap
- , Noboru Mizushima
- , Gregory D Cuny
- , Timothy J Mitchison
- , Michael A Moskowitz
- & Junying Yuan
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Article |
A molecular basis for NO selectivity in soluble guanylate cyclase
- Elizabeth M Boon
- , Shirley H Huang
- & Michael A Marletta
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Article |
General acid catalysis by the hepatitis delta virus ribozyme
- Subha R Das
- & Joseph A Piccirilli
