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Article |
Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer
- Baozhi Chen
- , Michael E Dodge
- , Wei Tang
- , Jianming Lu
- , Zhiqiang Ma
- , Chih-Wei Fan
- , Shuguang Wei
- , Wayne Hao
- , Jessica Kilgore
- , Noelle S Williams
- , Michael G Roth
- , James F Amatruda
- , Chuo Chen
- & Lawrence Lum
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Article |
Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein
- Daouda A K Traoré
- , Abdelnasser El Ghazouani
- , Lilian Jacquamet
- , Franck Borel
- , Jean-Luc Ferrer
- , David Lascoux
- , Jean-Luc Ravanat
- , Michel Jaquinod
- , Geneviève Blondin
- , Christelle Caux-Thang
- , Victor Duarte
- & Jean-Marc Latour
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Article |
Transport and signaling via the amino acid binding site of the yeast Gap1 amino acid transceptor
- Griet Van Zeebroeck
- , Beatriz Monge Bonini
- , Matthias Versele
- & Johan M Thevelein
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Article |
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects
- Jonathan Z Long
- , Weiwei Li
- , Lamont Booker
- , James J Burston
- , Steven G Kinsey
- , Joel E Schlosburg
- , Franciso J Pavón
- , Antonia M Serrano
- , Dana E Selley
- , Loren H Parsons
- , Aron H Lichtman
- & Benjamin F Cravatt
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Article |
Substrate selection by the proteasome during degradation of protein complexes
- Sumit Prakash
- , Tomonao Inobe
- , Ace Joseph Hatch
- & Andreas Matouschek
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Article |
ε-Poly-L-lysine dispersity is controlled by a highly unusual nonribosomal peptide synthetase
- Kazuya Yamanaka
- , Chitose Maruyama
- , Hiroshi Takagi
- & Yoshimitsu Hamano
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Article |
Spatial localization of bacteria controls coagulation of human blood by 'quorum acting'
- Christian J Kastrup
- , James Q Boedicker
- , Andrei P Pomerantsev
- , Mahtab Moayeri
- , Yao Bian
- , Rebecca R Pompano
- , Timothy R Kline
- , Patricia Sylvestre
- , Feng Shen
- , Stephen H Leppla
- , Wei-Jen Tang
- & Rustem F Ismagilov
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Article |
Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily
- Abhishek Chatterjee
- , Yue Li
- , Yang Zhang
- , Tyler L Grove
- , Michael Lee
- , Carsten Krebs
- , Squire J Booker
- , Tadhg P Begley
- & Steven E Ealick
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Article |
CD15 expression in human myeloid cell differentiation is regulated by sialidase activity
- Samah Zeineb Gadhoum
- & Robert Sackstein
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Article |
Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase
- Elsa D Garcin
- , Andrew S Arvai
- , Robin J Rosenfeld
- , Matt D Kroeger
- , Brian R Crane
- , Gunilla Andersson
- , Glen Andrews
- , Peter J Hamley
- , Philip R Mallinder
- , David J Nicholls
- , Stephen A St-Gallay
- , Alan C Tinker
- , Nigel P Gensmantel
- , Antonio Mete
- , David R Cheshire
- , Stephen Connolly
- , Dennis J Stuehr
- , Anders Åberg
- , Alan V Wallace
- , John A Tainer
- & Elizabeth D Getzoff
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Article |
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
- Beth Apsel
- , Jimmy A Blair
- , Beatriz Gonzalez
- , Tamim M Nazif
- , Morri E Feldman
- , Brian Aizenstein
- , Randy Hoffman
- , Roger L Williams
- , Kevan M Shokat
- & Zachary A Knight
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Article |
Cortisone dissociates the Shaker family K+ channels from their β subunits
- Yaping Pan
- , Jun Weng
- , Venkataraman Kabaleeswaran
- , Huiguang Li
- , Yu Cao
- , Rahul C Bhosle
- & Ming Zhou
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Article |
A sodium-mediated structural switch that controls the sensitivity of Kir channels to PtdIns(4,5)P2
- Avia Rosenhouse-Dantsker
- , Jin L Sui
- , Qi Zhao
- , Radda Rusinova
- , Aldo A Rodríguez-Menchaca
- , Zhe Zhang
- & Diomedes E Logothetis
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Article |
Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
- Paul E O'Maille
- , Arthur Malone
- , Nikki Dellas
- , B Andes Hess Jr
- , Lidia Smentek
- , Iseult Sheehan
- , Bryan T Greenhagen
- , Joe Chappell
- , Gerard Manning
- & Joseph P Noel
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Article |
Identification of a copper-binding metallothionein in pathogenic mycobacteria
- Ben Gold
- , Haiteng Deng
- , Ruslana Bryk
- , Diana Vargas
- , David Eliezer
- , Julia Roberts
- , Xiuju Jiang
- & Carl Nathan
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Article |
A domino effect in antifolate drug action in Escherichia coli
- Yun Kyung Kwon
- , Wenyun Lu
- , Eugene Melamud
- , Nurussaba Khanam
- , Andrew Bognar
- & Joshua D Rabinowitz
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Article |
Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae
- Kristy M Hawkins
- & Christina D Smolke
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Article |
Cytosporone B is an agonist for nuclear orphan receptor Nur77
- Yanyan Zhan
- , Xiping Du
- , Hangzi Chen
- , Jingjing Liu
- , Bixing Zhao
- , Danhong Huang
- , Guideng Li
- , Qingyan Xu
- , Mingqing Zhang
- , Bart C Weimer
- , Dong Chen
- , Zhe Cheng
- , Lianru Zhang
- , Qinxi Li
- , Shaowei Li
- , Zhonghui Zheng
- , Siyang Song
- , Yaojian Huang
- , Zhiyun Ye
- , Wenjin Su
- , Sheng-Cai Lin
- , Yuemao Shen
- & Qiao Wu
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Article |
β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana
- Zheming Wang
- , Christian Gu
- , Tom Colby
- , Takayuki Shindo
- , Rengarajan Balamurugan
- , Herbert Waldmann
- , Markus Kaiser
- & Renier A L van der Hoorn
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Article |
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
- Rémi Lasserre
- , Xiao-Jun Guo
- , Fabien Conchonaud
- , Yannick Hamon
- , Omar Hawchar
- , Anne-Marie Bernard
- , Saïdi M'Homa Soudja
- , Pierre-François Lenne
- , Hervé Rigneault
- , Daniel Olive
- , Georges Bismuth
- , Jacques A Nunès
- , Bernard Payrastre
- , Didier Marguet
- & Hai-Tao He
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Article |
An integrated platform of genomic assays reveals small-molecule bioactivities
- Shawn Hoon
- , Andrew M Smith
- , Iain M Wallace
- , Sundari Suresh
- , Molly Miranda
- , Eula Fung
- , Michael Proctor
- , Kevan M Shokat
- , Chao Zhang
- , Ronald W Davis
- , Guri Giaever
- , Robert P St Onge
- & Corey Nislow
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Article |
Estimation of the available free energy in a LOV2-Jα photoswitch
- Xiaolan Yao
- , Michael K Rosen
- & Kevin H Gardner
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Article |
A potent mechanism-inspired O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo
- Scott A Yuzwa
- , Matthew S Macauley
- , Julia E Heinonen
- , Xiaoyang Shan
- , Rebecca J Dennis
- , Yuan He
- , Garrett E Whitworth
- , Keith A Stubbs
- , Ernest J McEachern
- , Gideon J Davies
- & David J Vocadlo
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Article |
13C NMR snapshots of the complex reaction coordinate of pyridoxal phosphate synthase
- Jeremiah W Hanes
- , Ivan Keresztes
- & Tadhg P Begley
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Article |
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis
- Emmelie Å Jansson
- , Liyue Huang
- , Ronny Malkey
- , Mirco Govoni
- , Carina Nihlén
- , Annika Olsson
- , Margareta Stensdotter
- , Joel Petersson
- , Lena Holm
- , Eddie Weitzberg
- & Jon O Lundberg
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Article |
Synthesis enables identification of the cellular target of leucascandrolide A and neopeltolide
- Olesya A Ulanovskaya
- , Jelena Janjic
- , Masato Suzuki
- , Simran S Sabharwal
- , Paul T Schumacker
- , Stephen J Kron
- & Sergey A Kozmin
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Article |
A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity
- Alessia Montagnoli
- , Barbara Valsasina
- , Valter Croci
- , Maria Menichincheri
- , Sonia Rainoldi
- , Vanessa Marchesi
- , Marcello Tibolla
- , Pierluigi Tenca
- , Deborah Brotherton
- , Clara Albanese
- , Veronica Patton
- , Rachele Alzani
- , Antonella Ciavolella
- , Francesco Sola
- , Antonio Molinari
- , Daniele Volpi
- , Nilla Avanzi
- , Francesco Fiorentini
- , Marina Cattoni
- , Sandra Healy
- , Dario Ballinari
- , Enrico Pesenti
- , Antonella Isacchi
- , Jurgen Moll
- , Aaron Bensimon
- , Ermes Vanotti
- & Corrado Santocanale
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Article |
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
- Nobutaka Kato
- , Tomoyo Sakata
- , Ghislain Breton
- , Karine G Le Roch
- , Advait Nagle
- , Carsten Andersen
- , Badry Bursulaya
- , Kerstin Henson
- , Jeffrey Johnson
- , Kota Arun Kumar
- , Felix Marr
- , Daniel Mason
- , Case McNamara
- , David Plouffe
- , Vandana Ramachandran
- , Muriel Spooner
- , Tove Tuntland
- , Yingyao Zhou
- , Eric C Peters
- , Arnab Chatterjee
- , Peter G Schultz
- , Gary E Ward
- , Nathanael Gray
- , Jeffrey Harper
- & Elizabeth A Winzeler
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Article |
Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity
- Gabriele Meloni
- , Vanessa Sonois
- , Tamara Delaine
- , Luc Guilloreau
- , Audrey Gillet
- , Justin Teissié
- , Peter Faller
- & Milan Vašák
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Article |
Activation of the endocannabinoid system by organophosphorus nerve agents
- Daniel K Nomura
- , Jacqueline L Blankman
- , Gabriel M Simon
- , Kazutoshi Fujioka
- , Roger S Issa
- , Anna M Ward
- , Benjamin F Cravatt
- & John E Casida
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Article |
Structural and biochemical evidence for a boat-like transition state in β-mannosidases
- Louise E Tailford
- , Wendy A Offen
- , Nicola L Smith
- , Claire Dumon
- , Carl Morland
- , Julie Gratien
- , Marie-Pierre Heck
- , Robert V Stick
- , Yves Blériot
- , Andrea Vasella
- , Harry J Gilbert
- & Gideon J Davies
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Article |
Identification of RIP1 kinase as a specific cellular target of necrostatins
- Alexei Degterev
- , Junichi Hitomi
- , Megan Germscheid
- , Irene L Ch'en
- , Olga Korkina
- , Xin Teng
- , Derek Abbott
- , Gregory D Cuny
- , Chengye Yuan
- , Gerhard Wagner
- , Stephen M Hedrick
- , Scott A Gerber
- , Alexey Lugovskoy
- & Junying Yuan
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Article |
Highly active and selective endopeptidases with programmed substrate specificities
- Navin Varadarajan
- , Sarah Rodriguez
- , Bum-Yeol Hwang
- , George Georgiou
- & Brent L Iverson
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Article |
Novel targets for Huntington's disease in an mTOR-independent autophagy pathway
- Andrea Williams
- , Sovan Sarkar
- , Paul Cuddon
- , Evangelia K Ttofi
- , Shinji Saiki
- , Farah H Siddiqi
- , Luca Jahreiss
- , Angeleen Fleming
- , Dean Pask
- , Paul Goldsmith
- , Cahir J O'Kane
- , Rodrigo Andres Floto
- & David C Rubinsztein
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Article |
NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses
- Kendall W Nettles
- , John B Bruning
- , German Gil
- , Jason Nowak
- , Sanjay K Sharma
- , Johnnie B Hahm
- , Kristen Kulp
- , Richard B Hochberg
- , Haibing Zhou
- , John A Katzenellenbogen
- , Benita S Katzenellenbogen
- , Younchang Kim
- , Andrzej Joachimiak
- & Geoffrey L Greene
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Article |
Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
- Shuang Chang
- , Steven M Bray
- , Zigang Li
- , Daniela C Zarnescu
- , Chuan He
- , Peng Jin
- & Stephen T Warren
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Article |
Progressive ordering with decreasing temperature of the phospholipids of influenza virus
- Ivan V Polozov
- , Ludmila Bezrukov
- , Klaus Gawrisch
- & Joshua Zimmerberg
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Article |
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum
- Shirin Arastu-Kapur
- , Elizabeth L Ponder
- , Urša Pečar Fonović
- , Sharon Yeoh
- , Fang Yuan
- , Marko Fonović
- , Munira Grainger
- , Carolyn I Phillips
- , James C Powers
- & Matthew Bogyo
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Article |
Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling
- Jean-Pierre Vilardaga
- , Viacheslav O Nikolaev
- , Kristina Lorenz
- , Sébastien Ferrandon
- , Zhenjie Zhuang
- & Martin J Lohse
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Article |
Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes
- Alexander Kaplun
- , Elad Binshtein
- , Maria Vyazmensky
- , Andrea Steinmetz
- , Ze'ev Barak
- , David M Chipman
- , Kai Tittmann
- & Boaz Shaanan
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Article |
A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex
- Aude Dupré
- , Louise Boyer-Chatenet
- , Rose M Sattler
- , Ami P Modi
- , Ji-Hoon Lee
- , Matthew L Nicolette
- , Levy Kopelovich
- , Maria Jasin
- , Richard Baer
- , Tanya T Paull
- & Jean Gautier
-
Article |
High-content single-cell drug screening with phosphospecific flow cytometry
- Peter O Krutzik
- , Janelle M Crane
- , Matthew R Clutter
- & Garry P Nolan
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Article |
Integrating high-content screening and ligand-target prediction to identify mechanism of action
- Daniel W Young
- , Andreas Bender
- , Jonathan Hoyt
- , Elizabeth McWhinnie
- , Gung-Wei Chirn
- , Charles Y Tao
- , John A Tallarico
- , Mark Labow
- , Jeremy L Jenkins
- , Timothy J Mitchison
- & Yan Feng
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Article |
Multienzyme docking in hybrid megasynthetases
- Carsten D Richter
- , Daniel Nietlispach
- , R William Broadhurst
- & Kira J Weissman
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Article |
Discovery and characterization of a marine bacterial SAM-dependent chlorinase
- Alessandra S Eustáquio
- , Florence Pojer
- , Joseph P Noel
- & Bradley S Moore
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Article |
An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission
- Jana K Shirey
- , Zixiu Xiang
- , Darren Orton
- , Ashley E Brady
- , Kari A Johnson
- , Richard Williams
- , Jennifer E Ayala
- , Alice L Rodriguez
- , Jürgen Wess
- , David Weaver
- , Colleen M Niswender
- & P Jeffrey Conn
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Article |
Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate
- Young-Sam Lee
- , Kexin Huang
- , Florante A Quiocho
- & Erin K O'Shea
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Article |
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
- Paul B Yu
- , Charles C Hong
- , Chetana Sachidanandan
- , Jodie L Babitt
- , Donna Y Deng
- , Stefan A Hoyng
- , Herbert Y Lin
- , Kenneth D Bloch
- & Randall T Peterson
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Article |
Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY
- Alison L Livingston
- , Valerie L O'Shea
- , Taewoo Kim
- , Eric T Kool
- & Sheila S David
