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  • Traditional production of therapeutic secretory proteins often experiences delays between protein synthesis and therapeutic effects. An inducible protease-dependent protein secretion technique allows the immediate secretion of pre-translated biotherapeutic agents after exposure to chemical cues, tumor-specific antigens or photons.

    • Tianlu Wang
    • Yubin Zhou
    News & Views
  • We developed a versatile lipid probe — MAO–SiR — to visualize the structure and dynamics of the inner mitochondrial membrane (IMM). MAO–SiR assembles in situ from two cell-permeant small molecules to image the IMM selectively, continuously and at super resolution for extended periods of time without extensive photobleaching or toxicity.

    Research Briefing
  • The quality of chemical tools and their appropriate use determine the quality and reliability of scientific data based on their use. Now, two papers extend criteria to new modalities and critically review adherence to established guidelines.

    • Stefan Knapp
    • Susanne Müller
    News & Views
  • Byong-Hun Jeon works in the Department of Earth Resources and Environmental Engineering at Hanyang University, South Korea. His research is focused on biodegradation of environmental contaminants. Nature Chemical Biology spoke to Byong-Hun about the chemical biology of phytoremediation and phycoremediation, and the opportunities that they offer.

    • Russell Johnson
  • Activation of STING-dependent signal transduction results in adaptive immune responses that promote antitumor immunity. A recent study has identified a small-molecule STING agonist that functions by binding to a newly discovered ligandable site to induce high-order STING oligomerization.

    • Ariana Sulpizio
    • Luke L. Lairson
    News & Views
  • Almost all terpenoids discovered so far have backbones made up of multiples of five carbon atoms. Here, the authors combine gene mining with biochemical characterization and chemical structure analysis to unveil an extensive class of terpenoids with 16 carbon atoms in bacteria.

    • Yao-Tao Duan
    • Aikaterini Koutsaviti
    • Sotirios C. Kampranis
  • A cell-based phenotypic screen led to the discovery of compounds called NVS-STGs, which bind to the N-terminal domain of STING and act as a molecular glue to induce higher-order oligomerization and activation.

    • Jie Li
    • Stephen M. Canham
    • Yan Feng
    ArticleOpen Access
  • Computational approaches are emerging as powerful tools for the discovery of antibiotics. A study now uses machine learning to discover abaucin, a potent antibiotic that targets the bacterial pathogen Acinetobacter baumannii.

    • Angela Cesaro
    • Cesar de la Fuente-Nunez
    News & Views
  • Protein lipidation is an important post-translational modification that can be difficult to study. New amino acids with side chains that mimic naturally occurring lipid modifications stand to facilitate the study of lipidated proteins.

    • Jeremy H. Mills
    News & Views