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  • Using structural and biochemical methods, Liang et al. revealed a C-terminal glutamine-end recognition mechanism of TRIM7 E3 ligases, which enables identification of substrates for TRIM7 and provides insight into the versatile functions of TRIM7 in viral infection and the C-degron pathway.

    • Xiao Liang
    • Jun Xiao
    • Heng Zhang
    Article
  • Elucidating the interactions between serum protein-bound nanoparticles and cell-surface receptors typically operates on a per protein–receptor interaction basis. Integration of omic approaches for testing thousands of interactions unbiasedly reveals important interactions that drive cellular uptake of nanoparticles.

    • Cecilia Ka Wing Chan
    • Sze Ho Gwyneth Lau
    • Chung Hang Jonathan Choi
    News & Views
  • Merging the generalized extracellular molecule sensor (GEMS) system with screening designed ankyrin repeat proteins (DARPins) identifies an advanced modular bispecific extracellular receptor (AMBER) for detection of fibrinogen degradation products.

    • Tobias Strittmatter
    • Yidan Wang
    • Martin Fussenegger
    Article Open Access
  • Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

    • Beomjong Song
    • Sangsu Bae
    News & Views
  • A hypercompact adenine base editor termed TaRGET-ABE was developed by fusing a catalytically inactive transposon-associated transposase B guided by an engineered RNA to deaminases, which achieves efficient A-to-G conversions via adeno-associated viral delivery in mammalian genomes.

    • Do Yon Kim
    • Yuhee Chung
    • Yong-Sam Kim
    Article
  • Emerging evidence shows that ubiquitination can occur on nonlysine residues and nonproteinaceous substrates. This perspective summarizes the recent discoveries in noncanonical ubiquitination and advocates the development of chemical biology tools for new substrate identification and mechanistic dissection.

    • Daniel R. Squair
    • Satpal Virdee
    Perspective
  • In the post-genomic era, many genes and regulatory elements remain uncharacterized, including riboswitches — RNA structures that control gene expression by directly binding metabolites. Here, a new type of metal-responsive riboswitch that senses sodium cations expands the bacterial Na+ metabolic repertoire.

    • Lauren Waters
    News & Views