Cell tagging with light

Autoinducer-fluorophore conjugates enable FRET in LuxR proteins in vitro and in cells

  • Matthew J. Styles
  • Michelle E. Boursier
  • Helen E. Blackwell
Article

Announcements

  • Abstract representation of a public transit system, symbolizing the pathways of cellular metabolism

    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

  • Microbe interacting with host cell

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in a special issue.

Nature Chemical Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Advertisement

    • Transposon-associated transposase B (TnpB) is the putative ancestor of Cas nucleases. A TnpB-based adenine base editor has now been developed that is small enough to be loaded into a single AAV vector without compromising editing activity.

      • Beomjong Song
      • Sangsu Bae
      News & Views
    • Emerging evidence shows that ubiquitination can occur on nonlysine residues and nonproteinaceous substrates. This perspective summarizes the recent discoveries in noncanonical ubiquitination and advocates the development of chemical biology tools for new substrate identification and mechanistic dissection.

      • Daniel R. Squair
      • Satpal Virdee
      Perspective
    • In the post-genomic era, many genes and regulatory elements remain uncharacterized, including riboswitches — RNA structures that control gene expression by directly binding metabolites. Here, a new type of metal-responsive riboswitch that senses sodium cations expands the bacterial Na+ metabolic repertoire.

      • Lauren Waters
      News & Views
    • Biomolecular condensates form and dissolve in response to a wide range of signals. A new study reports a solubility-based phosphoproteome-profiling approach, which uncovers the extensive role of phosphorylation in regulating protein partitioning into condensates across the human proteome.

      • Kamran Rizzolo
      • Diana M. Mitrea
      News & Views
    • Chemical probes are powerful tools for the discovery of ligand-binding and drug-target sites on proteins. A new software helps to profile their performance in chemoproteomic applications.

      • Alexander Leitner
      News & Views

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
Collection

Advertisement

Nature Careers

Events

Jobs

Advertisement