Peaks and valleys of GPCR signaling

Molecular mechanism of GPCR spatial organization at the plasma membrane

  • Gabriele Kockelkoren
  • Line Lauritsen
  • Dimitrios Stamou


  • Drops of dew condensing on leaves

    This themed issue presents a collection of Reviews, Perspectives and Articles that aim to reveal the molecular and chemical principles underlying phase-separated condensate formation and promote the development and use of new tools for the study of phase separation biology.

Nature Chemical Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • NinaB is an isomerooxygenase that generates visual chromophore (11-cis-retinal) from carotenoid substrates. Here Solano et al. reveal the structural basis for NinaB isomerase activity, providing new insights into the evolution of visual chromophore synthesis by carotenoid cleavage enzymes.

    • Yasmeen J. Solano
    • Michael P. Everett
    • Philip D. Kiser
    ArticleOpen Access
  • BURP-domain proteins are an unexplored family of plant-specific, copper-dependent peptide cyclases. Here the authors show that a BURP-domain protein has a particular protein fold, investigate its mechanism and provide evidence for intramolecular modification in RiPP biosynthesis.

    • Lisa S. Mydy
    • Jordan Hungerford
    • Roland D. Kersten
  • α-Synuclein and tau can form multiple amyloid structures or strains that are associated with different neurodegenerative diseases, suggesting a strain–toxicity relationship. Now, it has been shown that O-GlcNAc modification of α-synuclein results in the formation of an amyloid strain that is largely nonpathogenic in vivo, supporting structure-dependent toxicity and another protective role for O-GlcNAc.

    • Aaron T. Balana
    • Anne-Laure Mahul-Mellier
    • Matthew R. Pratt
    ArticleOpen Access
  • SUGAR-TARGET is a modular platform for the homogeneous synthesis of enzymes with controlled N-linked glycosylation using a one-step immobilization/purification method.

    • Elli Makrydaki
    • Roberto Donini
    • Cleo Kontoravdi
    ArticleOpen Access
    • Developing inhibitors for SH2 domains is challenging due to their shallow pockets and highly charged ligands. Structure-guided drug design has enabled the discovery of a cell-permeable covalent inhibitor of the SOCS2 SH2 domain, a key regulator of cytokine signaling pathways.

      • Oliver Hantschel
      News & Views
    • O-linked N-acetylglucosamine (O-GlcNAc) is an endogenous form of glycosylation that alters the structure of α-synuclein amyloid fibrils and attenuates their pathogenetic properties. The modified fibrils have a significantly reduced ability to seed the aggregation of endogenous α-synuclein in cultured neurons and in mice brains in vivo, which results in reduced pathology.

      Research Briefing
    • Nonribosomal peptide synthetases produce diverse natural products, including many valuable therapeutics. Although the condensation domains that catalyze peptide bond formation in these multifunctional enzymes have been difficult to engineer, a yeast display system that was developed to screen millions of variants now enables efficient reprogramming of synthetase substrate specificity.

      Research Briefing
    • Transporters and channels have strong potential as drug targets, but drug discovery targeting these membrane-embedded molecules is challenging. Fragment-based ligand discovery combined with chemical proteomics offers a promising solution to the search for inhibitors of solute transporter family members.

      • Noriko Toyama-Sorimachi
      News & Views
    • Sulfated compounds produced collaboratively by the microbiome and the host have important biological functions. This Review highlights the production of select sulfated carbohydrates, amino acid derivatives and steroidal metabolites and discusses their influence on health. The Review also explore potential roles of sulfated molecules in disease detection, prevention and treatment.

      • Gabriel D. D’Agostino
      • Snehal N. Chaudhari
      • A. Sloan Devlin
      Review Article

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.


Nature Careers

Science jobs