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  • Abstract representation of a public transit system, symbolizing the pathways of cellular metabolism

    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

  • Microbe interacting with host cell

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in a special issue.

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    • Antigen loading onto class I major histocompatibility complex (MHC-I) proteins relies on chaperones and protein flexibility. Researchers now provide new insight into the process, especially for the intriguing ‘non-classical’ MHC-I protein MR1, with implications for fundamental immunology and the development of novel immunotherapies.

      • Tatiana J. Rosales
      • Brian M. Baker
      News & Views
    • Carbon dioxide (CO2) is a product of cellular respiration that can also serve as a post-translational modification (PTM) through covalent protein modification. A new chemoproteomic strategy enables the capture of functional CO2-dependent carboxylation on lysine residues of proteins.

      • R. Justin Grams
      • Ku-Lung Hsu
      News & Views
    • The rising threat of antifungal resistance means that alternative therapeutics need to be considered. New research explores the biochemical basis of virulence inhibition by mucus glycans against the fungal pathogen Candida albicans.

      • Jehoshua Sharma
      • Rebecca S. Shapiro
      News & Views
    • A fungal ten-eleven translocation (TET) dioxygenase homolog, CcTet, is found to have both 5-methylcytosine (5mC) and N6-methyladenine (6mA) demethylase activity. Structure-based engineering of CcTet yielded a 6mA-specific demethylase, offering a useful tool for the manipulation and functional study of 6mA.

      • Sisi Li
      • Jiamu Du
      News & Views
    • The discovery of long-existing terpenoid biosynthetic pathways in soft corals changes the way specialized metabolism in animals is thought about, and opens unprecedented access to the largely untapped treasure trove of medicinal marine natural products.

      • Trinh-Don Nguyen
      • Thu-Thuy T. Dang
      News & Views

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
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