Drops of dew condensing on the leaves symbolizing condensates formed via phase separation in cells

Synthetic protein condensates for cellular and metabolic engineering

  • Zhi-Gang Qian
  • Sheng-Chen Huang
  • Xiao-Xia Xia
Review Article

Announcements

  • Abstract representation of a public transit system, symbolizing the pathways of cellular metabolism

    This themed issue presents a collection of Reviews, Perspectives and Articles that aims to showcase how chemical tools have strengthened the existing interplay between physiology, chemical biology and biochemistry – to reveal new insights into cellular regulation.

  • Microbe interacting with host cell

    Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in a special issue.

Nature Chemical Biology is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.

Advertisement

    • Major hurdles remain in understanding the mechanisms of multidrug resistance (MDR) protein efflux. A new study uses deep mutational scanning of a bacterial MDR protein to determine the nature of its drug-binding cavity and understand its function and plasticity.

      • Parjit Kaur
      News & Views
    • High-mannose N-glycans are common post-translational modifications that occur on many proteins. The mechanism by which these high-mannose N-glycans are consumed by species of Bifidobacterium has now been characterized, which is important given their positive role in human gut microbiota and their abundance in breastfed infants.

      • Lucy I. Crouch
      News & Views
    • This perspective proposes general strategies for phase-separation-related biological studies, including proper experimental designs to validate and characterize phase-separation phenomena, connections to biological functions and some caveats to avoid common misunderstandings.

      • Yifei Gao
      • Xi Li
      • Yi Lin
      Perspective
    • Protein condensates are subcellular structures that enrich and confine molecules in cells. This Review details how condensates can be engineered with responsiveness and on-demand functions, thus pushing cellular and metabolic engineering to a new level.

      • Zhi-Gang Qian
      • Sheng-Chen Huang
      • Xiao-Xia Xia
      Review Article
    • This Review introduces molecular features of the phase-separating biomolecules and how they affect phase-separation behavior in a complex intracellular environment, highlighting a complex interplay between structure, sequence and environment in the phase-separation process.

      • José A. Villegas
      • Meta Heidenreich
      • Emmanuel D. Levy
      Review Article

Chemical Biology of Microbiomes

Interspecies communication in complex microbiome environments occurs through the small molecules, peptides, and proteins produced by both the host and the microbial residents, as highlighted in this collection of recent articles from Nature Portfolio.
Collection

Advertisement

Nature Careers

Events

Advertisement